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BRCA1: linking HOX to breast cancer suppression.

Abstract：

:Homeobox (HOX) genes play key roles in embryogenesis and tissue differentiation. Recently, a number of groups have reported altered HOX gene expression in breast cancer. However, the mechanism of HOX gene regulation and the search for direct targets of its transcriptional regulatory function have been minimally fruitful. Recently, Gilbert and colleagues reported that HOXA9 restrains breast cancer progression by upregulation of BRCA1, a tumor suppressor. This finding raises our hope that more, rather elusive targets of HOX genes important in tumor progression or suppression will be found in the future.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Jin K,Sukumar S

doi

10.1186/bcr2600

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

306

issue

4

eissn

1465-5411

issn

1465-542X

pii

bcr2600

journal_volume

12

pub_type

杂志文章

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