Molecular drivers of lobular carcinoma in situ.

Abstract:

:Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecules, such as PIK3CA and c-src, are consistently altered in LCIS. This review focuses on the molecular drivers of lobular carcinoma, a more complete understanding of which may give perspective on which LCIS lesions progress, and which will not, thus having immense clinical implications.

journal_name

Breast Cancer Res

authors

Logan GJ,Dabbs DJ,Lucas PC,Jankowitz RC,Brown DD,Clark BZ,Oesterreich S,McAuliffe PF

doi

10.1186/s13058-015-0580-5

subject

Has Abstract

pub_date

2015-06-04 00:00:00

pages

76

eissn

1465-5411

issn

1465-542X

pii

10.1186/s13058-015-0580-5

journal_volume

17

pub_type

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