Hormonal control of p53 and chemoprevention.


:Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of menarche, and age at menopause are major risk factors drawing attention to the important role of the endocrine system in determining the risk of breast cancer, while heritable breast cancer susceptibility syndromes have implicated tumor suppressor genes as important targets. Recent work demonstrating hormonal modulation of the p53 tumor suppressor pathway draws together these established determinants of risk to provide a model of developmental susceptibility to breast cancer. In this model, the mammary epithelium is rendered susceptible due to impaired p53 activity during specific periods of mammary gland development, but specific endocrine stimuli serve to activate p53 function and to mitigate this risk. The results focus attention on p53 as a molecular target for therapies to reduce the risk of breast cancer.


Breast Cancer Res


Jerry DJ,Minter LM,Becker KA,Blackburn AC





Has Abstract


2002-01-01 00:00:00












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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章,评审


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    更新日期:2002-01-01 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 评论,杂志文章,评审


    authors: Tremblay ML

    更新日期:2013-07-31 00:00:00

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    journal_title:Breast cancer research : BCR

    pub_type: 杂志文章


    authors: Gibby K,You WK,Kadoya K,Helgadottir H,Young LJ,Ellies LG,Chang Y,Cardiff RD,Stallcup WB

    更新日期:2012-04-24 00:00:00