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Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.

Abstract：

INTRODUCTION:Molecular apocrine (MA) tumors are estrogen receptor (ER) negative breast cancers characterized by androgen receptor (AR) expression. We analyzed a group of 58 transcriptionally defined MA tumors and proposed a new tool to identify these tumors. METHODS:We performed quantitative reverse transcription PCR (qRT-PCR) for ESR1, AR, FOXA1 and AR-related genes, and immunohistochemistry (IHC) for ER, PR, Human Epidermal Growth Factor Receptor 2 (HER2), CK5/6, CK17, EGFR, Ki67, AR, FOXA1 and GCDFP15 and we analyzed clinical features. RESULTS:MA tumors were all characterized by ESR1(-) AR(+) FOXA1(+) and AR-related genes positive mRNA profile. IHC staining on these tumors showed 93% ER(-), only 58% AR(+) and 90% FOXA1(+). 67% and 57% MA tumors were HER2(3+) and GCDFP15(+), respectively. Almost all MA tumors (94%) had the IHC signature HER2(3+) or GCDFP15(+) but none of the 13 control basal-like (BL) tumors did. Clinically, MA tumors were rather aggressive, with poor prognostic factors. CONCLUSION:MA tumors could be better defined by their qRT-PCR-AR profile than by AR IHC. In addition, we found that HER2 or GCDFP15 protein overexpression is a sensitive and specific tool to differentiate MA from BL in the context of ER negative tumors. A composite molecular and IHC signature could, therefore, help to identify MA tumors in daily practice.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Lehmann-Che J,Hamy AS,Porcher R,Barritault M,Bouhidel F,Habuellelah H,Leman-Detours S,de Roquancourt A,Cahen-Doidy L,Bourstyn E,de Cremoux P,de Bazelaire C,Albiter M,Giacchetti S,Cuvier C,Janin A,Espié M,de Thé H,Bert

doi

10.1186/bcr3421

subject

Has Abstract

pub_date

2013-05-11 00:00:00

pages

R37

issue

3

eissn

1465-5411

issn

1465-542X

pii

bcr3421

journal_volume

15

pub_type

杂志文章

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