Abstract:
:ABSTRACTThis prospective, double-blind trial was performed to determine whether 4 weeks' prophylaxis with enoxaparin after total hip replacement (THR) is more effective in protecting against deep vein thrombosis (DVT) than prophylaxis during hospitalization. Two hundred sixty-two patients undergoing THR were given enoxaparin 40 mg once daily during hospitalization (9 ± 2 days) before being randomized at discharge to continue enoxaparin (N=131) or receive placebo (N=131) for a total of 1 month (30 ± 4 days). According to intention-to-treat analysis, 43 DVT and 2 pulmonary emboli (PE) occurred in the placebo group (34.4%) versus 21 DVT and no PE in the enoxaparin group (P<0.001). The reduction in proximal DVT was also significant (21.4 vs 6.1%; P<0.001). No major bleeding complications developed. Prophylaxis with enoxaparin for one month significantly reduces venous thromboembolic disease in patients undergoing THR compared to conventional prophylaxis during hospitalization.
journal_name
Orthopedicsjournal_title
Orthopedicsauthors
Nilsson PE,Bergqvist D,Benoni G,Björgell O,Fredin H,Hedlund U,Nicolas S,Nylander Gdoi
10.3928/0147-7447-19970202-09subject
Has Abstractpub_date
1997-02-01 00:00:00pages
22-5eissn
0147-7447issn
1938-2367journal_volume
20pub_type
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