An injectable calcium sulfate-based bone graft putty using hydroxypropylmethylcellulose as the plasticizer.

Abstract:

:The addition of a plasticizer to synthetic bone graft substitutes can improve handling characteristics, injectability, and the ability to uniformly fill defects. Restoration of large medullary bone defects using an injectable calcium sulfate-based putty using hydroxypropylmethylcellose as the plasticizer was compared to conventional calcium sulfate paste in a canine model. Beginning 2 weeks following implantation, serial clinical and specimen radiographs demonstrated a similar progressive resorption of the implanted materials and replacement with new bone for both the putty and paste forms of calcium sulfate. The area fraction of new bone and remaining implant material in bone defects treated with the putty were not significantly different from defects treated with conventional calcium sulfate paste after 13 and 26 weeks. In addition to its handling characteristics, the putty was biocompatible and as effective as conventional calcium sulfate paste in achieving substantial bony restoration of a large, critical-size bone defect.

journal_name

Orthopedics

journal_title

Orthopedics

authors

Urban RM,Turner TM,Hall DJ,Infanger SI,Cheema N,Lim TH,Richelsoph K

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

s155-9

issue

1 Suppl

eissn

0147-7447

issn

1938-2367

journal_volume

27

pub_type

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