Abstract:
:Malignant granular cell tumor is a rare neural tumor characterized by abundant granular-appearing tumor cells. These tumors account for <2% of all granular cell tumors. Unlike its benign counterpart, a malignant granular cell tumor presents primarily in the lower limb and is notably larger. Both the uncommon occurrence of malignant granular cell tumors and its similarities in feature with their benign counterparts make diagnosis of this particular malignancy difficult. By 1998, Fanburg-Smith et al developed a diagnostic criteria in which granular cell tumors were divided into 3 categories-benign, atypical, and malignant-based on 6 histological characteristics of the tumor: necrosis, spindling, vesicular nuclei with large nucleoli, increased mitotic activity, high nuclear-to-cytoplasmic ratio, and pleomorphism. This article presents a case of a large malignant granular cell tumor in the right thigh of a 69-year-old woman. Gross examination of the mass showed the well-demarcated, tan, white tumor measuring 18.2 cm long and 7.6 cm wide at its largest width. Histological examination of the mass, performed by an oncological pathologist, demonstrated foci of tumor necrosis, scattered apoptotic cells, prominent nucleoli, increased nuclear-to-cytoplasmic ratio, increased mitotic activity, and areas of spindling with significant atypia. To our knowledge, this is the largest reported case of malignant granular cell tumor in the lower limb diagnosed using the histological criteria established by Fanburg-Smith et al. This case stresses the importance of thorough evaluation in instances of atypical granular cell tumor presentations.
journal_name
Orthopedicsjournal_title
Orthopedicsauthors
Hwang JS,Beebe KS,Rojas J,Peters SRdoi
10.3928/01477447-20110627-31subject
Has Abstractpub_date
2011-08-08 00:00:00pages
e428-31issue
8eissn
0147-7447issn
1938-2367journal_volume
34pub_type
杂志文章相关文献
ORTHOPEDICS文献大全abstract::This study evaluated patients who were given transcutaneous electrical nerve stimulation (TENS) compared with a matched group without TENS prior to intervention and at 1-year follow-up. Patients who were treated with TENS had significantly fewer hospital and clinic visits, used less diagnostic imaging (31 vs 46 events...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20131120-04
更新日期:2013-12-01 00:00:00
abstract::Thyroid acropachy is a rare complication of thyroid disease most often occurring in patients with a long history of active Graves' disease with ophthalmopathy and dermopathy already present. It presents with digital clubbing and soft tissue swelling with possible pain in the digits. Plain radiographs show a solid peri...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20080101-38
更新日期:2008-01-01 00:00:00
abstract::Retrieved polyethylene liners and femoral heads from a consecutive series of revision components of one design were examined. All patients had Long-Term Stable Fixation (OsteoTechnology International, Timonium, Md) total hip arthroplasties (THAs) implanted between 1987 and 1992. The retrieved femoral heads and liners ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::Shoulder dislocation is an injury with potential long-term consequences that requires prompt diagnosis and treatment. Patient positioning and imperfect radiographic views may result in discomfort, added examination time, and problematic diagnosis. The scapular Y radiograph has been shown to be useful in diagnosing sho...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20110317-15
更新日期:2011-05-01 00:00:00
abstract::The best screening method for developmental dysplasia of the hip is controversial. Ultrasonography is sensitive, but cost-effectiveness may limit its use. This study assessed whether ultrasound screening would increase in effectiveness if targeted toward infants with established risk factors for developmental dysplasi...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20150804-61
更新日期:2015-08-01 00:00:00
abstract::Inserting pins at a single location of the iliac crest temporarily provides an effective splint for emergency patients with pelvic ring fractures. For a longer application, however, this procedure frequently causes infection and pin loosening and does not effectively stabilize the pelvic construct. We presumed biplana...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20090511-21
更新日期:2009-06-01 00:00:00
abstract::The three-dimensional periacetabular bone architecture has been established by sectioning multiple pelves in coronal, parasagittal, and horizontal planes. Maximum compressive and tensile stresses were determined by a finite element model of the acetabulum. The architecture is symmetric in a given specimen, and quite s...
journal_title:Orthopedics
pub_type: 社论
doi:10.3928/0147-7447-19820301-04
更新日期:1982-03-01 00:00:00
abstract::Radiocarpal fracture-dislocations are uncommon injuries, comprising a spectrum of trauma to the capsuloligamentous complex and osseous structures of the radiocarpal joint along with the adjacent structures. Management guidelines are derived from limited case series and expert opinions. An understanding of the relevant...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20130523-07
更新日期:2013-06-01 00:00:00
abstract::Though originally designed to facilitate the management of primary malignant bone tumors, the indications for the Howmedica Oncology modular endoprostheses have expanded to include the reconstruction of metastatic lesions, failed internal fixation of difficult trauma problems, and failed conventional and custom tumor ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The operative treatment of olecranon fractures is controversial. Proponents of open reduction and internal fixation cite restoration of anatomy and rigid fixation, while proponents of excision of fracture fragments with repair of the extensor mechanism cite few complications and a rapid return of motion and function. ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::The Bateman Universal Proximal Femoral Assembly has been used primarily in the treatment of subcapital fractures of the femoral head when the acetabulum was judged to be adequate. The indications for this procedure are the same as for a standard hemiarthroplasty. A contraindication against its use is a severe neurolog...
journal_title:Orthopedics
pub_type: 社论
doi:10.3928/0147-7447-19801001-05
更新日期:1980-10-01 00:00:00
abstract::With advanced surgical techniques, instrumentation, and implants, arthroscopic rotator cuff repair has become increasingly popular. As the techniques continue to evolve, so do the methods by which the repairs are tested. Cyclic loading has shown to better replicate postoperative motion after cuff repair. Recently, cyc...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20091124-12
更新日期:2010-01-01 00:00:00
abstract::The synovium of dogs receiving an osteochondral allograft of the distal femur has similar characteristics to a rheumatoid synovium. Since it is generally believed that the cartilage destruction in rheumatoid arthritis is related to the release of hydrolases from lysosomes, the following study was performed to determin...
journal_title:Orthopedics
pub_type: 社论
doi:10.3928/0147-7447-19820701-05
更新日期:1982-07-01 00:00:00
abstract::The incidence of musculoskeletal injury sustained during tobacco farming has been poorly documented. Using the trauma registry for all farm-related injuries occurring during a 16-month period, hospital charts, radiographs, and clinic charts were reviewed to identify those patients sustaining tobacco farming-related in...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive protein that plays a pivotal role in bone growth and regeneration. Studies conducted in many mammalian species and, most recently, human clinical studies, have provided definitive evidence of the ability of rhBMP-2 to induce bone. The findin...
journal_title:Orthopedics
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1999-07-01 00:00:00
abstract::The goal of this study was to compare treatment outcomes of screw proximal femoral nails and helical proximal femoral nails and to investigate the effectiveness of helical proximal femoral nails for the treatment of intertrochanteric fractures. Forty patients with intertrochanteric fractures were treated at our instit...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20100104-11
更新日期:2010-02-01 00:00:00
abstract::This study determined the relationship of various pelvic landmarks to the pelvic plane in the lateral position. Five whole-body cadavers were used in this study. All navigation data were collected using the OrthoPilot navigation system (B. Braun Aesculap, Tuttlingen, Germany) to register all landmarks. The pelvic plan...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20090915-51
更新日期:2009-10-01 00:00:00
abstract::We hypothesized that less malalignment and complications occur with intramedullary nailing of distal third tibia fractures (42A, B, C) after the implementation of orthopedic trauma surgeons to this level II community hospital. We also hypothesized that patients with < or =5 degrees of malalignment have poorer function...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Limb salvage is the treatment of choice for malignant shoulder girdle tumors; however, there is a paucity of data examining the long-term outcome. The authors have previously reported on a cohort of patients at short- and mid-term follow-up. The purpose of this study was to report the long-term outcome of shoulder rec...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20191001-01
更新日期:2019-11-01 00:00:00
abstract::Animal models are commonly used for translational research despite evidence that the methodology of these studies is often inconsistent and substandard. This study describes the characteristics and impact of published research using animal models in the American Journal of Sports Medicine (AJSM). Peer-reviewed article...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20120822-30
更新日期:2012-09-01 00:00:00
abstract::Many studies have described the diversity of synovial sarcoma in terms of its biological characteristics and clinical features. Moreover, much effort has been expended on the identification of prognostic factors because of unpredictable behaviors of synovial sarcomas. However, with the exception of tumor size, publish...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20090922-12
更新日期:2009-11-01 00:00:00
abstract::Twelve matched pairs of humerii were instrumented with suture anchor at 90 degrees, 75 degrees, 45 degrees, and 30 degrees relative to the cortical border at the junction of the greater tuberosity and articular surface. Two fixtures were inserted into each specimen at different angles and loaded to failure. Suture anc...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract::This study reviews the results of 94 computed tomography (CT)-guided Craig needle biopsies of the spine and sacrum performed at one center. An indication for biopsy in this study was prompted by abnormal findings identified by one or more of the following diagnostic modalities: radiography, CT, magnetic resonance imag...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::A 40-year-old male weightlifter presented with a 6-month history of a painless mass in the right deltoid. He had no history of trauma to the shoulder other than an arthroscopic rotator cuff repair a few weeks earlier. Physical examination showed a firm, nontender mass located longitudinally and coinciding with the del...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20140825-92
更新日期:2014-09-01 00:00:00
abstract::A new biomaterial made of nickel and titanium with its shape-memory characteristics has been manufactured, investigated, and used in Shanghai, China. Since 1981, this biomaterial has been used in 265 cases clinically, among which 71 involved orthopedic surgery. Results are satisfactory without failure in our short-ter...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::One hundred ninety-seven consecutive primary cemented total hip arthroplasties using 22 mm heads were evaluated for the rate of dislocation. All surgery was performed by one surgeon through a posterior approach. A Charnley type femoral component was used in each case. Patients were divided into three groups based on t...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::The goal of this study was to verify or reject the hypothesis that systematic differences exist in various profibrotic or antifibrotic factors between osteoarthritic patients and controls, as well as between different stages of osteoarthritis. The study group comprised 63 patients with knee osteoarthritis and 18 contr...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20100625-09
更新日期:2010-08-11 00:00:00
abstract::Is there a correlation between increased posterior-inferior tibial slope angle and noncontact anterior cruciate ligament (ACL) injury? Does increasing the posterior-inferior tibial slope angle increase the risk of bilateral ACL injury? A computerized relational database (Access 2007; Microsoft Inc, Redmond, Washington...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20161013-06
更新日期:2017-01-01 00:00:00
abstract::The humeral heads of whole body cadaveric shoulders underwent fluoroscopic evaluation with the head divided into three zones on both anteroposterior (AP) and axillary views creating nine zones. Five AP and three axillary fluoroscopic images in different rotational positions were assessed for pin penetration. All image...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20070801-04
更新日期:2007-08-01 00:00:00
abstract::In the United States, demand for total hip arthroplasty (THA) and THA revision procedures are increasing due to an aging population, a longer life expectancy, and an increasing prevalence of osteoarthritis. This retrospective cohort study identified patients 65 years and older in the Medicare 5% Standard Analytic File...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20181120-03
更新日期:2019-01-01 00:00:00