Cyclosporin for Crohn's disease.

abstract：BACKGROUND:Irritable bowel syndrome (IBS) has been associated with microbial dysbiosis. AIM:To investigate the efficacy of faecal microbiota transplantation (FMT) in the treatment of IBS. METHODS:Forty-nine IBS patients were randomised to receive autologous or allogenic FMT via colonoscopy. The primary endpoint was a...

journal_title：Alimentary pharmacology & therapeutics

authors： Lahtinen P,Jalanka J,Hartikainen A,Mattila E,Hillilä M,Punkkinen J,Koskenpato J,Anttila VJ,Tillonen J,Satokari R,Arkkila P

更新日期：2020-06-01 00:00:00

abstract：:The aetiology of Crohn's disease is unknown and therefore no curative treatments are available for the disease. The natural history of Crohn's disease is characterized by recurrent flare-ups of symptoms. Several drug treatments are effective in inducing clinical remission. However, no drug treatments are available in ...

journal_title：Alimentary pharmacology & therapeutics

authors： Biancone L,Tosti C,Fina D,Fantini M,De Nigris F,Geremia A,Pallone F

更新日期：2003-06-01 00:00:00

abstract：AIM:To assess the pathophysiology and treatment of neurogenic dysphagia. METHODS:46 patients with brain damage, 46 with neurodegenerative diseases and eight healthy volunteers were studied by videofluoroscopy while swallowing 3-20 mL liquid (20.4 mPa s), nectar (274.4 mPa s) and pudding (3931.2 mPa s) boluses. RESULT...

journal_title：Alimentary pharmacology & therapeutics

authors： Clavé P,de Kraa M,Arreola V,Girvent M,Farré R,Palomera E,Serra-Prat M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:There is no consensus on the standard treatment of gastric mucosa-associated lymphoid tissue (MALT) lymphoma for Helicobacter pylori-negative patients and for patients with persistent disease despite H. pylori eradication. AIM:To evaluate the comparative efficacy and safety of alkylating agents and rituxima...

journal_title：Alimentary pharmacology & therapeutics

authors： Amiot A,Lévy M,Copie-Bergman C,Dupuis J,Szablewski V,Le Baleur Y,Baia M,Belhadj K,Sobhani I,Leroy K,Haioun C,Delchier JC

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Pregabalin has a broad spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies. However, its mechanisms and sites of action have yet to be determined in humans. AIMS:To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalge...

journal_title：Alimentary pharmacology & therapeutics

authors： Olesen SS,Graversen C,Olesen AE,Frøkjaer JB,Wilder-Smith O,van Goor H,Valeriani M,Drewes AM

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Triple therapy currently forms the cornerstone of the treatment of patients with Helicobacter pylori-positive duodenal ulcer. AIM:To establish whether prolonged antisecretory therapy is necessary in patients with active duodenal ulcer. METHODS:A total of 77 patients with H. pylori-positive duodenal ulcer w...

journal_title：Alimentary pharmacology & therapeutics

authors： Tepes B,Krizman I,Gorensek M,Gubina M,Orel I

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Consensus guidelines aid in the diagnosis and management of autoimmune hepatitis, but they are frequently based on low-quality clinical evidence, conflicting experiences and divergent opinions. Recommendations may be weak, discrepant or non-existent at critical decision points. AIMS:To identify the decision...

journal_title：Alimentary pharmacology & therapeutics

authors： Czaja AJ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Endothelins have been implicated in gastric mucosal damage in a variety of animal models. Exogenous ET-1 and ET-3 are causally associated with experimental gastric ulcers. Furthermore, clinical reports also show elevated plasma and gastric mucosal endothelin-1 levels in patients suffering from peptic ulcers....

journal_title：Alimentary pharmacology & therapeutics

authors： Padol I,Huang JQ,Hunt RH

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Real-life long-term data on infliximab treatment in ulcerative colitis are limited. AIM:To study the long-term efficacy and safety of infliximab in chronic active ulcerative colitis and possible predictors of colectomy and response were also examined. METHODS:A retrospective multi-centre study of inflixima...

journal_title：Alimentary pharmacology & therapeutics

authors： Angelison L,Almer S,Eriksson A,Karling P,Fagerberg U,Halfvarson J,Thörn M,Björk J,Hindorf U,Löfberg R,Bajor A,Hjortswang H,Hammarlund P,Grip O,Torp J,Marsal J,Hertervig E,Swedish Organization for the Study of Inflammato

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Anti-ulcer agents exert various functional effects on gastric epithelial cells. AIM:The effects of a novel gastro-cytoprotective agent (rebamipide) on epithelial restoration following bile acid damage were assessed using primary cultured rabbit gastric epithelial cells. METHODS:Rebamipide was added to comp...

journal_title：Alimentary pharmacology & therapeutics

authors： Watanabe S,Wang XE,Hirose M,Yoshizawa T,Iwazaki R,Oide H,Kitamura T,Miwa H,Miyazaki A,Sato N

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Considerable information has been gathered on the functional organization of enteric neuronal circuitries regulating gastrointestinal motility. However, little is known about the neuropathophysiological mechanisms underlying gastrointestinal motor disorders. AIM:To analyse the most important pathological fi...

journal_title：Alimentary pharmacology & therapeutics

authors： Di Nardo G,Blandizzi C,Volta U,Colucci R,Stanghellini V,Barbara G,Del Tacca M,Tonini M,Corinaldesi R,De Giorgio R

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The gastric juice concentration of vitamin C is reduced in subjects with elevated intragastric pH. This is probably because of the fact that the vitamin is unstable at non-acidic pH and undergoes irreversible denaturation. AIM:To determine whether elevation of intragastric pH reduces the bioavailability of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Henry EB,Carswell A,Wirz A,Fyffe V,McColl KE

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) frequently affects women during their reproductive years. Pregnancy outcome in women with IBD is well described, particularly in retrospective studies. AIM:To evaluate the pregnancy outcome in patients with IBD in a prospective European multicentre case-control study. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： Bortoli A,Pedersen N,Duricova D,D'Inca R,Gionchetti P,Panelli MR,Ardizzone S,Sanroman AL,Gisbert JP,Arena I,Riegler G,Marrollo M,Valpiani D,Corbellini A,Segato S,Castiglione F,Munkholm P,European Crohn-Colitis Organisat

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:In patients with primary sclerosing cholangitis follow-up magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) is performed by many centres, particularly for the early detection of biliary malignancies and strictures. Clinically meaningful MRI-based definitions of primary ...

journal_title：Alimentary pharmacology & therapeutics

authors： Zenouzi R,Liwinski T,Yamamura J,Weiler-Normann C,Sebode M,Keller S,Lohse AW,Schramm C,International PSC Study Group (IPSCSG).

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) are a leading cause of drug-induced liver injury (DILI) across the world. Ibuprofen is one of the most commonly used and safest NSAIDs, nevertheless reports on ibuprofen-induced hepatotoxicity are available. AIM:To analyse previously published information on ibu...

journal_title：Alimentary pharmacology & therapeutics

authors： Zoubek ME,Lucena MI,Andrade RJ,Stephens C

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Psychiatric co-morbidity, in particular major depression and anxiety, is common in patients with Crohn's disease (CD) and ulcerative colitis (UC). Prior studies examining this may be confounded by the co-existence of functional bowel symptoms. Limited data exist examining an association between depression or...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Gainer VS,Perez RG,Cai T,Cheng SC,Savova G,Chen P,Szolovits P,Xia Z,De Jager PL,Shaw SY,Churchill S,Karlson EW,Kohane I,Perlis RH,Plenge RM,Murphy SN,Liao KP

更新日期：2013-02-01 00:00:00

abstract：AIM:To identify optimal antibiotics for second-line quadruple therapy of Helicobacter pylori after failed 1-week triple therapy. METHODS:One hundred patients were enrolled in this study after the failure of 1-week triple therapy. They were randomized to receive 1-week quadruple therapy consisting of amoxicillin, omepr...

journal_title：Alimentary pharmacology & therapeutics

authors： Chi CH,Lin CY,Sheu BS,Yang HB,Huang AH,Wu JJ

更新日期：2003-08-01 00:00:00

abstract：:Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut. Visc...

journal_title：Alimentary pharmacology & therapeutics

authors： Mertz H

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss. METHODS:We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg-negative patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Tseng TC,Liu CJ,Chen CL,Yang WT,Yang HC,Su TH,Wang CC,Kuo SF,Liu CH,Chen PJ,Chen DS,Kao JH

更新日期：2015-05-01 00:00:00

abstract：:Forty patients with gastro-oesophageal reflux disease and oesophagitis, documented by endoscopy (grades I to III by the Savary-Miller classification) were randomized to participate in a comparative double-blind trial to receive cisapride (10 mg q.d.s.) or ranitidine (150 mg b.d.) for an 8-week period. Upper gastrointe...

journal_title：Alimentary pharmacology & therapeutics

authors： Arvanitakis C,Nikopoułos A,Theoharidis A,Giannoulis E,Vagios I,Anthopoulou H,Michailidis D,Tourkantonis A

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Differentiating symptoms of irritable bowel syndrome from those of organic intestinal disease is a common clinical problem. Several neutrophil-derived proteins have been proposed as a marker of inflammatory bowel disease. AIM:To compare the diagnostic value of faecal calprotectin, lactoferrin and polymorpho...

journal_title：Alimentary pharmacology & therapeutics

authors： Schröder O,Naumann M,Shastri Y,Povse N,Stein J

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Variation in the characteristics of irritable bowel syndrome patients recruited for clinical trials from different sources could affect their response and the generalizability of trial results. AIM:To describe and compare the characteristics of three different groups of irritable bowel syndrome patients rec...

journal_title：Alimentary pharmacology & therapeutics

authors： Longstreth GF,Hawkey CJ,Mayer EA,Jones RH,Naesdal J,Wilson IK,Peacock RA,Wiklund IK

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Most array analyses of ulcerative colitis have focused on identifying susceptibility genes for ulcerative colitis. AIM:To clarify the changes in gene expression during inflammation in ulcerative colitis colon mucosa using cDNA macroarray. METHODS:From 23 ulcerative colitis patients, 16 each of inflamed and...

journal_title：Alimentary pharmacology & therapeutics

authors： Okahara S,Arimura Y,Yabana T,Kobayashi K,Gotoh A,Motoya S,Imamura A,Endo T,Imai K

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Alginates form a raft above the gastric contents, which may suppress gastro-oesophageal reflux; however, inconsistent effects have been reported in mechanistic and clinical studies. AIMS:To visualise reflux suppression by an alginate-antacid [Gaviscon Advance (GA), Reckitt Benckiser, UK] compared with a non...

journal_title：Alimentary pharmacology & therapeutics

authors： Sweis R,Kaufman E,Anggiansah A,Wong T,Dettmar P,Fried M,Schwizer W,Avvari RK,Pal A,Fox M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is very common in India, as in other developing countries, but few data exist on the susceptibility of H. pylori to antimicrobial agents commonly used for eradication here. AIM:To determine the antimicrobial susceptibility of H. pylori strains from Kolkata, in eastern India. M...

journal_title：Alimentary pharmacology & therapeutics

authors： Datta S,Chattopadhyay S,Patra R,De R,Ramamurthy T,Hembram J,Chowdhury A,Bhattacharya SK,Berg DE,Nair GB,Mukhopadhyay AK

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Occult biliary stones escape detection on conventional investigations, and clinico-biochemical systems proposed for predicting biliary pancreatitis has low predictive values. AIM:To evaluate the accuracy of clinico-biochemical parameters for prediction of biliary pancreatitis in patients undergoing endoscop...

journal_title：Alimentary pharmacology & therapeutics

authors： Liu CL,Fan ST,Lo CM,Tso WK,Wong Y,Poon RT,Lam CM,Wong BC,Wong J

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Studies to date have not directly compared the pharmacodynamic efficacies of different proton pump inhibitors in controlling intragastric acidity in patients treated with non-steroidal anti-inflammatory drugs. AIM:To compare acid suppression with once-daily esomeprazole 40 mg, lansoprazole 30 mg and pantopr...

journal_title：Alimentary pharmacology & therapeutics

authors： Goldstein JL,Miner PB Jr,Schlesinger PK,Liu S,Silberg DG

更新日期：2006-04-15 00:00:00

abstract：BACKGROUND:Gastro-oesophageal reflux disease (GERD) is one of the commonest diseases of Western populations, affecting 20 to 30% of adults. GERD is multifaceted and the classical oesophageal symptoms such as heartburn and regurgitation often overlap with atypical symptoms that impact upon the respiratory system and air...

journal_title：Alimentary pharmacology & therapeutics

authors： Pearson JP,Parikh S,Orlando RC,Johnston N,Allen J,Tinling SP,Johnston N,Belafsky P,Arevalo LF,Sharma N,Castell DO,Fox M,Harding SM,Morice AH,Watson MG,Shields MD,Bateman N,McCallion WA,van Wijk MP,Wenzl TG,Karkos

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:A novel potassium-competitive acid blocker, DWP14012, is in clinical development as a potential alternative to proton pump inhibitors for the treatment of acid-related diseases. AIMS:To evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012 in humans. METHODS:A randomised, dou...

journal_title：Alimentary pharmacology & therapeutics

authors： Sunwoo J,Oh J,Moon SJ,Ji SC,Lee SH,Yu KS,Kim HS,Lee A,Jang IJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Idiopathic noncirrhotic portal hypertension (INCPH) has been reported increasingly in patients with HIV infection. AIM:To evaluate the number of nationwide diagnosed HIV-associated INCPH cases and to assess its clinical features, risk factors and outcome. METHODS:All HIV centres in the Netherlands were con...

journal_title：Alimentary pharmacology & therapeutics

authors： Schouten JN,Van der Ende ME,Koëter T,Rossing HH,Komuta M,Verheij J,van der Valk M,Hansen BE,Janssen HL

更新日期：2012-11-01 00:00:00