Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin.

abstract：BACKGROUND:Transjugular intrahepatic portosystemic stent-shunts (TIPSS) are becoming widely used in the management of oesophageal variceal haemorrhage (OVH). Their place in the treatment of gastric variceal haemorrhage (GVH), a condition with a traditionally poor prognosis, remains unclear. The aims of our study were t...

journal_title：Alimentary pharmacology & therapeutics

authors： Stanley AJ,Jalan R,Ireland HM,Redhead DN,Bouchier IA,Hayes PC

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Pneumatic dilatation is the first line therapy in achalasia, but half of patients relapse within 5 years of therapy and require further dilatations. AIM:To assess whether botulinum toxin injection before pneumatic dilatation is superior to pneumatic dilatation alone in achalasia patients. METHODS:Newly dia...

journal_title：Alimentary pharmacology & therapeutics

authors： Mikaeli J,Bishehsari F,Montazeri G,Mahdavinia M,Yaghoobi M,Darvish-Moghadam S,Farrokhi F,Shirani S,Estakhri A,Malekzadeh R

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:Regulatory requirements for claims of mucosal healing in ulcerative colitis (UC) will require demonstration of both endoscopic and histologic healing. Quantifying these rates is essential for future drug development. AIMS:To meta-analyse endoscopic and histologic placebo response and remission rates in UC r...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Guizzetti L,Panaccione R,Fedorak RN,Pai RK,Parker CE,Nguyen TM,Khanna R,Vande Casteele N,D'Haens G,Sandborn WJ,Feagan BG,Jairath V

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Variation in the characteristics of irritable bowel syndrome patients recruited for clinical trials from different sources could affect their response and the generalizability of trial results. AIM:To describe and compare the characteristics of three different groups of irritable bowel syndrome patients rec...

journal_title：Alimentary pharmacology & therapeutics

authors： Longstreth GF,Hawkey CJ,Mayer EA,Jones RH,Naesdal J,Wilson IK,Peacock RA,Wiklund IK

更新日期：2001-07-01 00:00:00

abstract：:Gastrin releasing peptide (GRP) has proved to be a particularly valuable tool in detecting disturbances of gastric secretory function associated with duodenal ulcer disease and Helicobacter pylori infection, and it has furthered understanding of the pathophysiology of these conditions. Its attractiveness lies in the f...

journal_title：Alimentary pharmacology & therapeutics

authors： McColl KE,el-Omar E

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Germinated barley foodstuff (GBF) has been shown to attenuate intestinal injury in animal models, largely by increasing luminal short-chain fatty acid production. AIM:To investigate the safety and efficacy of GBF in the treatment of ulcerative colitis (UC). METHODS:Ten patients with active UC received 30 g...

journal_title：Alimentary pharmacology & therapeutics

authors： Mitsuyama K,Saiki T,Kanauchi O,Iwanaga T,Tomiyasu N,Nishiyama T,Tateishi H,Shirachi A,Ide M,Suzuki A,Noguchi K,Ikeda H,Toyonaga A,Sata M

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Gastric cancer can be divided into cardia and noncardia gastric adenocarcinoma (NCGA). Non cardia gastric cancer is a disease that has declined in global incidence but has remained as an extremely lethal cancer. AIM:To review recent advances in epidemiology and strategies in prevention of non cardia gastric...

journal_title：Alimentary pharmacology & therapeutics

authors： Fock KM

更新日期：2014-08-01 00:00:00

abstract：AIM:: To quantify through systematic review the pharmacokinetic profiles of the oral delayed release and sustained release mesalazine (5-aminosalicylate, 5ASA) formulations (Asacol, Salofalk, Mesasal, Claversal, Pentasa) and pro-drugs (sulfasalazine, olsalazine, balsalazide) used in the management of ulcerative colitis...

journal_title：Alimentary pharmacology & therapeutics

authors： Sandborn WJ,Hanauer SB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention. AIM:To rev...

journal_title：Alimentary pharmacology & therapeutics

authors： Soffer E,Abell T,Lin Z,Lorincz A,McCallum R,Parkman H,Policker S,Ordog T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Refractory sprue with malabsorption carries a risk of lymphoma. AIM:To examine whether a good clinical but poor histological response during a strict gluten-free diet predicts a poor outcome. METHODS:The study involved all coeliac patients who showed no histological recovery within 2 years on a strict glut...

journal_title：Alimentary pharmacology & therapeutics

authors： Kaukinen K,Peräaho M,Lindfors K,Partanen J,Woolley N,Pikkarainen P,Karvonen AL,Laasanen T,Sievänen H,Mäki M,Collin P

更新日期：2007-05-15 00:00:00

abstract：:Alginate-based raft-forming formulations have been marketed word-wide for over 30 years under various brand names, including Gaviscon. They are used for the symptomatic treatment of heartburn and oesophagitis, and appear to act by a unique mechanism which differs from that of traditional antacids. In the presence of g...

journal_title：Alimentary pharmacology & therapeutics

authors： Mandel KG,Daggy BP,Brodie DA,Jacoby HI

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:A short-term course of pegylated-interferon (Peg-IFN), or a long-term treatment with a third generation nucleot(s)ide analogue (NUC), of chronic hepatitis B (CHB) infection achieves viral suppression and may prevent disease progression. Owing to different mechanisms of action of the two regimens, a Peg-IFN a...

journal_title：Alimentary pharmacology & therapeutics

authors： Viganò M,Invernizzi F,Grossi G,Lampertico P

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:It has been shown that azathioprine prolongs the response to ciclosporin of steroid-refractory ulcerative colitis, but no specific data are available concerning its toxicity in this indication. AIM AND METHODS:The charts of 21 patients with steroid-refractory ulcerative colitis who received azathioprine ove...

journal_title：Alimentary pharmacology & therapeutics

authors： Actis GC,Bresso F,Astegiano M,Demarchi B,Sapone N,Boscaglia C,Rizzetto M

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Mesalazine suppositories are recommended and widely used as the standard therapy in induction and maintenance of remission for proctitis. AIM:To evaluate the efficacy of mesalazine suppositories in patients with ulcerative colitis (UC) and rectal inflammation; and in patient groups categorised by the extent...

journal_title：Alimentary pharmacology & therapeutics

authors： Watanabe M,Nishino H,Sameshima Y,Ota A,Nakamura S,Hibi T

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:We have observed an increase in hepatotoxicity (DILI) reporting related to the use of anabolic androgenic steroids (AAS) for bodybuilding. AIM:To characterise phenotype presentation, outcome and severity of AAS DILI. METHODS:Data on 25 cases of AAS DILI reported to the Spanish (20) and Latin-American (5) D...

journal_title：Alimentary pharmacology & therapeutics

authors： Robles-Diaz M,Gonzalez-Jimenez A,Medina-Caliz I,Stephens C,García-Cortes M,García-Muñoz B,Ortega-Alonso A,Blanco-Reina E,Gonzalez-Grande R,Jimenez-Perez M,Rendón P,Navarro JM,Gines P,Prieto M,Garcia-Eliz M,Bessone F,Brahm

更新日期：2015-01-01 00:00:00

abstract：:Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one tablet q.d.s.) in twe...

journal_title：Alimentary pharmacology & therapeutics

authors： Prewett EJ,Luk YW,Fraser AG,Lam WM,Pounder RE

更新日期：1992-02-01 00:00:00

abstract：:All vertebrates secrete gastric acid. Acid denatures the proteins in the food and thus makes them more accessible to proteolytic enzymes, and it kills swallowed micro-organisms. Gastric acid plays an important pathogenetic role in peptic ulcer disease and reflux oesophagitis. In these diseases, drugs that inhibit secr...

journal_title：Alimentary pharmacology & therapeutics

authors： Waldum HL,Brenna E,Kleveland PM,Sandvik AK,Syversen U

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Alginates form a raft above the gastric contents, which may suppress gastro-oesophageal reflux; however, inconsistent effects have been reported in mechanistic and clinical studies. AIMS:To visualise reflux suppression by an alginate-antacid [Gaviscon Advance (GA), Reckitt Benckiser, UK] compared with a non...

journal_title：Alimentary pharmacology & therapeutics

authors： Sweis R,Kaufman E,Anggiansah A,Wong T,Dettmar P,Fried M,Schwizer W,Avvari RK,Pal A,Fox M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:In behavioural economics, a 'nudge' describes configuration of a choice to encourage a certain action without taking away freedom of choice. AIM:To determine the impact of a 'nudge' strategy - prefilling either 3mL or 5mL syringes with midazolam - on endoscopic sedation practice. METHODS:Consecutive patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Harewood GC,Clancy K,Engela J,Abdulrahim M,Lohan K,O'Reilly C

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Barrett's oesophagus is the major risk factor for oesophageal adenocarcinoma. 5-Aminlevulinic acid-induced photodynamic therapy and argon plasma coagulation have been shown to be effective for ablating Barrett's oesophagus, but a comparative trial of these two modalities has not been reported. AIMS:To compa...

journal_title：Alimentary pharmacology & therapeutics

authors： Kelty CJ,Ackroyd R,Brown NJ,Stephenson TJ,Stoddard CJ,Reed MW

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Therapy with adalimumab has been shown to be effective in Crohn's disease (CD) patients who have lost response or are intolerant to infliximab. AIM:To determine the efficacy of adalimumab in CD patients who discontinued infliximab through a systematic review. METHODS:Electronic searches of EMBASE and MEDLI...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Panaccione R,Heitman SJ,Devlin SM,Ghosh S,Kaplan GG

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:Vitamin D has immune-regulatory functions in experimental colitis, and low vitamin D levels are present in Crohn's disease. AIM:To assess the effectiveness of vitamin D3 treatment in Crohn's disease with regard to improved disease course. METHODS:We performed a randomized double-blind placebo-controlled tr...

journal_title：Alimentary pharmacology & therapeutics

authors： Jørgensen SP,Agnholt J,Glerup H,Lyhne S,Villadsen GE,Hvas CL,Bartels LE,Kelsen J,Christensen LA,Dahlerup JF

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

journal_title：Alimentary pharmacology & therapeutics

authors： Houlihan DD,Holt A,Elliot C,Ferguson JW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Following a nil per os (NPO) regimen, most patients with acute pancreatitis (AP) can resume normal oral intake within 1 week. If not tolerated, it is recommended to initiate artificial feeding, preferably by the enteral route. AIM:To evaluate the nutritional management of patients with AP in a Dutch cohort ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spanier BW,Mathus-Vliegen EM,Tuynman HA,Van der Hulst RW,Dijkgraaf MG,Bruno MJ,EARL Study Group.

更新日期：2008-11-01 00:00:00

abstract：:In a randomly allocated, double-blind, endoscopically controlled study, 98 patients with gastric ulcers were treated with either (a synthetic prostaglandin of E2-like structure) enprostil 70 micrograms b.d. or 150 mg ranitidine b.d. The healing rates at 4, 8 and 12 weeks were enprostil 57, 91 and 94% and for ranitidin...

journal_title：Alimentary pharmacology & therapeutics

authors： Morgan AG,Pacsoo C,Taylor P,McAdam WA

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Colitis is a significant complication of immune checkpoint inhibitors (ICI). Currently, clinical and endoscopic severity are used to guide therapy. AIMS:To investigate associations between clinical, endoscopic, and histological features with outcomes METHODS: We identified 149 patients from seven institutio...

journal_title：Alimentary pharmacology & therapeutics

authors： Pai RK,Pai RK,Brown I,Choi WT,Schaeffer DF,Farnell D,Kumarasinghe MP,Gunawardena D,Kim BH,Friedman M,Ghayouri M,Lauwers GY

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:4-Aminosalicylic acid has the potential for use in the treatment of diseases of the colon. AIM:To assess the feasibility of delivering 4-aminosalicylic acid directly to the colon using a hydroxypropylmethylcellulose capsule coated with a mixture of amylose, a polysaccharide metabolized by bacterial enzymes ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tuleu C,Basit AW,Waddington WA,Ell PJ,Newton JM

更新日期：2002-10-01 00:00:00

abstract：:In the era of expanding medical therapy for ulcerative colitis, surgery is still a very valid option in those patients, where medicine is not able to control symptoms, both in the acute and chronic stages, and also for those at risk of developing a cancer. The ileal pouch-anal anastomosis (IPAA) will, for the vast maj...

journal_title：Alimentary pharmacology & therapeutics

authors： Oresland T

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Surgical resection of Crohn's disease is followed by early recurrence in a high percentage of patients. Mesalazine has been shown to be effective in the prevention of post-operative recurrence, but some 50% of patients under treatment recur at 3 years of follow-up. AIM:To establish whether the mucosal conce...

journal_title：Alimentary pharmacology & therapeutics

authors： Frieri G,Pimpo MT,Andreoli A,Annese V,Comberlato M,Corrao G,Palumbo G,Sturniolo GC,Tonelli F,Caprilli R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Retrospective accounts suggest that therapeutic doses of paracetamol can produce severe hepatic injury in patients with putative high-risk conditions, including alcoholism and infectious hepatitis. Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also hav...

journal_title：Alimentary pharmacology & therapeutics

authors： Dart RC,Green JL,Kuffner EK,Heard K,Sproule B,Brands B

更新日期：2010-08-01 00:00:00