Regulatory barriers to clinical trial enrollment of adolescent and young adult oncology patients.

abstract：:Assay of ornithine transcarbamylase (OTC) activity in multiple small bits of liver (approximately 5 mg) that were obtained from a single surgical biopsy in a patient with OTC deficiency revealed a 10- to 40-fold variation in enzyme activity. Similar studies with control autopsy liver specimens varied 2.5-fold at most....

journal_title：Pediatrics

authors： Glasgow AM,Kraegel JH,Schulman JD

更新日期：1978-07-01 00:00:00

abstract：OBJECTIVES:To determine if giving vaccine-information materials before the 2-month vaccination visit to mothers with concerns about vaccine safety positively changed their attitudes and beliefs about vaccine safety. METHODS:Mothers who indicated concerns about infant vaccinations were recruited from 2 separate sites i...

journal_title：Pediatrics

authors： Vannice KS,Salmon DA,Shui I,Omer SB,Kissner J,Edwards KM,Sparks R,Dekker CL,Klein NP,Gust DA

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Depression is common among adolescents, but rates increase significantly in the presence of chronic health conditions. Outpatient screening for depression is recommended but rarely formally conducted due to barriers of implementation. METHODS:To provide a model for depression screening of youth with chronic ...

journal_title：Pediatrics

authors： Corathers SD,Kichler J,Jones NH,Houchen A,Jolly M,Morwessel N,Crawford P,Dolan LM,Hood KK

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Use of specific services may help to optimize health for children with autism spectrum disorder (ASD); however, little is known about their service use patterns. We aimed to (1) define service use groups and (2) determine associations of sociodemographic, developmental, behavioral, and health ...

journal_title：Pediatrics

authors： Lindly OJ,Chan J,Levy SE,Parker RA,Kuhlthau KA

更新日期：2020-04-01 00:00:00

abstract：:Withdrawal of steroid medications from patients who have been receiving them for management of chronic disease carries the risk of certain serious complications. An understanding of adrenal physiology, coupled with a rational plan for evaluating the individual patient, when necessary, and for protecting against certai...

journal_title：Pediatrics

authors： Chamberlin P,Meyer WJ 3rd

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Low socioeconomic status (SES) has emerged as an important risk factor for higher short-term mortality and neurodevelopmental outcomes in children with hypoplastic left heart syndrome and related anomalies; yet little is known about how SES affects these outcomes over the long-term. METHODS:We linked data f...

journal_title：Pediatrics

authors： Bucholz EM,Sleeper LA,Goldberg CS,Pasquali SK,Anderson BR,Gaynor JW,Cnota JF,Newburger JW

更新日期：2020-10-01 00:00:00

abstract：:The collaborative national survey on morbidity and mortality in preterm and small for gestational age infants in the Netherlands enrolled initially 1338 infants born in 1983. The relationship between maximal serum total bilirubin concentration in the neonatal period and neurodevelopmental outcome in the survivors of t...

journal_title：Pediatrics

authors： van de Bor M,Ens-Dokkum M,Schreuder AM,Veen S,Brand R,Verloove-Vanhorick SP

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Childhood obesity is epidemic and may be associated with PICU mortality. Using a large multicenter PICU database, we investigated the association between obesity and PICU mortality, adjusting for initial severity of illness. We further investigated whether height- and weight-based classificati...

journal_title：Pediatrics

authors： Ross PA,Newth CJ,Leung D,Wetzel RC,Khemani RG

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Childhood asthma prevalence doubled from 1980 to 1995 and then increased more slowly from 2001 to 2010. During this second period, racial disparities increased. More recent trends remain to be described. METHODS:We analyzed current asthma prevalence using 2001-2013 National Health Interview Survey data for ...

journal_title：Pediatrics

authors： Akinbami LJ,Simon AE,Rossen LM

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To examine long-term outcomes of toddlers with autism spectrum disorder (ASD) who received a 6-month early intervention at age 2. METHODS:Forty-eight toddlers diagnosed with an ASD received a 6-month evidence-based intervention. Cognitive (IQ) and communication ability, as well as severity of autism symptom...

journal_title：Pediatrics

authors： Landa RJ,Kalb LG

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Obtaining information on children's health and health events is heavily dependent on maternal report. Experience as to what factors influence accuracy of reporting varies, and few studies have examined the influence of current child health status on recall. METHODS:A prospective cohort study involving 1833 ...

journal_title：Pediatrics

authors： McCormick MC,Brooks-Gunn J

更新日期：1999-11-01 00:00:00

abstract：:Since 1961 the Committee on Nutrition of the American Academy of Pediatrics has recommended that prophylactic vitamin K be administered parenterally to all newborn infants, although the exact requirement for vitamin K in the newborn infant is unknown. There is little information about the vitamin K1 (phylloquinone, pr...

journal_title：Pediatrics

authors： Greer FR,Mummah-Schendel LL,Marshall S,Suttie JW

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To determine whether an adequate volume of sweat could be obtained routinely from infants younger than 6 weeks old and to evaluate sweat chloride levels in infants with known genotype statuses, including heterozygote carriers for cystic fibrosis (CF). METHODOLOGY:Infants were evaluated using pilocarpine iont...

journal_title：Pediatrics

authors： Farrell PM,Koscik RE

更新日期：1996-04-01 00:00:00

abstract：:Tumor-induced osteomalacia/rickets is a rare paraneoplastic disorder associated with a tumor-producing fibroblast growth factor 23 (FGF23). We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma (CGCG) with high serum levels of FGF23, a hormone associated with decrease...

journal_title：Pediatrics

authors： Fernández-Cooke E,Cruz-Rojo J,Gallego C,Romance AI,Mosqueda-Peña R,Almaden Y,Sánchez del Pozo J

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To examine among adolescents (1) the prevalence of neck/shoulder, low back, and arm pain within different sociodemographic groups and (2) the association of neck/shoulder, low back, and arm pain with computer use, physical activity, depression, and stress. METHODS:A school-based questionnaire survey in 2002 ...

journal_title：Pediatrics

authors： Diepenmaat AC,van der Wal MF,de Vet HC,Hirasing RA

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The goal was to determine whether home asthma telemonitoring with store-and-forward technology improved outcomes, compared with in-person, office-based visits. METHODS:A total of 120 patients, 6 to 17 years of age, with persistent asthma were assigned randomly to the office-based or virtual group. The 2 grou...

journal_title：Pediatrics

authors： Chan DS,Callahan CW,Hatch-Pigott VB,Lawless A,Proffitt HL,Manning NE,Schweikert M,Malone FJ

更新日期：2007-03-01 00:00:00

abstract：:Swaddling was an almost universal child-care practice before the 18th century. It is still tradition in certain parts of the Middle East and is gaining popularity in the United Kingdom, the United States, and The Netherlands to curb excessive crying. We have systematically reviewed all articles on swaddling to evaluat...

journal_title：Pediatrics

authors： van Sleuwen BE,Engelberts AC,Boere-Boonekamp MM,Kuis W,Schulpen TW,L'Hoir MP

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Data from the 1988 National Health Interview Survey--Child Health Supplement were used to examine the prevalence of selected developmental disabilities and their impact among children ages 0 through 17 years. DESIGN:The following conditions, identified through a structured in-person interview with a parent o...

journal_title：Pediatrics

authors： Boyle CA,Decouflé P,Yeargin-Allsopp M

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To examine clinician-reported diagnosis of obesity and frequency of blood pressure assessment and diet and exercise counseling during ambulatory visits made by children and adolescents. METHODS:The National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey 1997 to 2000 were ...

journal_title：Pediatrics

authors： Cook S,Weitzman M,Auinger P,Barlow SE

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this work was to evaluate whether education about zinc supplements and provision of zinc supplements to caregivers is effective in the treatment of acute diarrhea and whether this strategy adversely affects the use of oral rehydration salts. PATIENTS AND METHODS:Six clusters of 30,000 people e...

journal_title：Pediatrics

authors： Bhandari N,Mazumder S,Taneja S,Dube B,Agarwal RC,Mahalanabis D,Fontaine O,Black RE,Bhan MK

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:This report describes a new fatal syndrome observed in adolescent males at the initial presentation of diabetes mellitus. The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability. DESIGN:Case se...

journal_title：Pediatrics

authors： Hollander AS,Olney RC,Blackett PR,Marshall BA

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:To increase weight gain in the first 28 days after birth for very low birth weight (VLBW) infants by isolating and sharing meaningful process differences between high- and low-weight-gain centers within a neonatal network. DESIGN/METHODS:We identified weight gain as an important target for improvement in 199...

journal_title：Pediatrics

authors： Bloom BT,Mulligan J,Arnold C,Ellis S,Moffitt S,Rivera A,Kunamneni S,Thomas P,Clark RH,Peabody J

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Despite concerted policy efforts, a sizeable percentage of children lack health insurance coverage. This article examines the impact of the health care safety net and health care market structure on the use of health care by uninsured children. METHODS:We used the Medical Expenditure Panel Survey linked with...

journal_title：Pediatrics

authors： Gresenz CR,Rogowski J,Escarce JJ

更新日期：2006-03-01 00:00:00

abstract：:A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was...

journal_title：Pediatrics

authors： Betzhold J,Hong R

更新日期：1978-07-01 00:00:00

abstract：OBJECTIVE:Adverse childhood experiences (ACEs) may have long-term consequences on at-risk behaviors that lead to an increased risk of sexually transmitted diseases (STDs) during adulthood. Therefore, we examined the relationship between ACEs and subsequent STDs for both men and women. METHODS:A total of 9323 (4263 men...

journal_title：Pediatrics

authors： Hillis SD,Anda RF,Felitti VJ,Nordenberg D,Marchbanks PA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:We aimed to describe the clinical features and outcome of human parechovirus (HPeV) encephalitis cases identified by the Australian Childhood Encephalitis (ACE) study. METHODS:Infants with suspected encephalitis were prospectively identified in 5 hospitals through the (ACE) study. Cases of confirmed HPeV inf...

journal_title：Pediatrics

authors： Britton PN,Dale RC,Nissen MD,Crawford N,Elliott E,Macartney K,Khandaker G,Booy R,Jones CA,PAEDS-ACE Investigators.

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Abusive head injuries among infants (shaken infant or shaken impact syndrome) represent a devastating form of child abuse; an effective prevention program that reduces the incidence of abusive head injuries could save both lives and the costs of caring for victims. We wished to determine whether a comprehensi...

journal_title：Pediatrics

authors： Dias MS,Smith K,DeGuehery K,Mazur P,Li V,Shaffer ML

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To determine the primary caretakers of children born to women with human immunodeficiency virus (HIV) infection. METHODS:We interviewed women at least 18 years of age who have been reported with HIV infection or acquired immunodeficiency syndrome to local health departments in 10 cities and states regarding ...

journal_title：Pediatrics

authors： Schable B,Diaz T,Chu SY,Caldwell MB,Conti L,Alston OM,Sorvillo F,Checko PJ,Hermann P,Davidson AJ

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:To 1) describe the characteristic features of fibromyalgia syndrome (FS) in a pediatric population, 2) note similarities and differences with FS in adults, and 3) determine outcome after treatment. SETTING AND DESIGN:The Pediatric Rheumatology Clinic at the University of Rochester Medical Center is staffed ...

journal_title：Pediatrics

authors： Siegel DM,Janeway D,Baum J

更新日期：1998-03-01 00:00:00

abstract：:To determine which warming system more closely approximates a neutral thermal environment, the oxygen consumption of 16 premature babies, weighing less than 1,500 gm each, was measured in a convectively heated incubator and under an open radiant warmer. Both systems were controlled to maintain a skin temperature of 36...

journal_title：Pediatrics

authors： LeBlanc MH

更新日期：1982-04-01 00:00:00