Frequent Implication of Multistress-Tolerant Campylobacter jejuni in Human Infections.

Abstract:

:Campylobacter jejuni, a major cause of bacterial foodborne illnesses, is considered highly susceptible to environmental stresses. In this study, we extensively investigated the stress tolerance of 121 clinical strains of C. jejuni against 5 stress conditions (aerobic stress, disinfectant exposure, freeze-thaw, heat treatment, and osmotic stress) that this pathogenic bacterium might encounter during foodborne transmission to humans. In contrast to our current perception about high stress sensitivity of C. jejuni, a number of clinical strains of C. jejuni were highly tolerant to multiple stresses. We performed population genetics analysis by using comparative genomic fingerprinting and showed that multistress-tolerant strains of C. jejuni constituted distinct clades. The comparative genomic fingerprinting subtypes belonging to multistress-tolerant clades were more frequently implicated in human infections than those in stress-sensitive clades. We identified unique stress-tolerant C. jejuni clones and showed the role of stress tolerance in human campylobacteriosis.

journal_name

Emerg Infect Dis

authors

Oh E,Chui L,Bae J,Li V,Ma A,Mutschall SK,Taboada EN,McMullen LM,Jeon B

doi

10.3201/eid2406.171587

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

1037-1044

issue

6

eissn

1080-6040

issn

1080-6059

journal_volume

24

pub_type

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