Abstract:
OBJECTIVES:We aimed to assess the diagnostic performance of a combined protocol with coronary computed tomography angiography (CCTA) and stress CT perfusion imaging (CTP) in heart transplant patients for comprehensive morphological and functional imaging. METHODS:In this prospective study, 13 patients undergoing routine follow-up 8±6 years after heart transplantation underwent CCTA and dynamic adenosine stress CTP using a third-generation dual-source CT scanner, cardiac magnetic resonance (MR) adenosine stress perfusion imaging at 1.5 T, and catheter coronary angiography. In CCTA stenoses >50% luminal diameter narrowing were noted. Myocardial perfusion deficits were documented in CTP and MR. Quantitative myocardial blood flow (MBF) was calculated with CTP. Left ventricular ejection fraction was determined on cardiac MR cine images. Radiation doses of CT were determined. RESULTS:One of the 13 patients had to be excluded because of severe motion artifacts. CCTA identified three patients with stenosis >50%, which were confirmed with catheter coronary angiography. CTP showed four patients with stress-induced myocardial hypoperfusion, which were confirmed by MR stress perfusion imaging. Quantitative analysis of global MBF showed lower mean values as compared to known reference values (MBF under stress 125.5 ± 34.5 ml/100 ml/min). Average left ventricular ejection fraction was preserved (56 ± 5%). CONCLUSIONS:In heart transplant patients, a comprehensive CT protocol for the assessment of morphology and function including CCTA and CTP showed good concordance to results from MR perfusion imaging and catheter coronary angiography. KEY POINTS:• Stress CT perfusion imaging enables the detection of myocardial ischemia • CT myocardial perfusion imaging can be combined with coronary computed tomography angiography • Combining perfusion and coronary CT imaging is accurate in heart transplant patients • CT myocardial perfusion imaging can be performed at a reasonable radiation dose.
journal_name
Eur Radioljournal_title
European radiologyauthors
Oebel S,Hamada S,Higashigaito K,von Spiczak J,Klotz E,Enseleit F,Hinzpeter R,Ruschitzka F,Manka R,Alkadhi Hdoi
10.1007/s00330-018-5436-9subject
Has Abstractpub_date
2018-10-01 00:00:00pages
4111-4121issue
10eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5436-9journal_volume
28pub_type
杂志文章abstract::Coincidence of dorsal defect on a multipartite patella constitutes a rare cause of anterior knee pain in the first decades of life. Imaging findings of this uncommon symptomatic skeletal variant are discussed, with emphasis on MR features. ...
journal_title:European radiology
pub_type: 杂志文章
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