Abstract:
OBJECTIVE:Despite 90 % of glioblastoma (GBM) recurrences occurring in the peritumoral brain zone (PBZ), its contribution in patient survival is poorly understood. The current study leverages computerized texture (i.e. radiomic) analysis to evaluate the efficacy of PBZ features from pre-operative MRI in predicting long- (>18 months) versus short-term (<7 months) survival in GBM. METHODS:Sixty-five patient examinations (29 short-term, 36 long-term) with gadolinium-contrast T1w, FLAIR and T2w sequences from the Cancer Imaging Archive were employed. An expert manually segmented each study as: enhancing lesion, PBZ and tumour necrosis. 402 radiomic features (capturing co-occurrence, grey-level dependence and directional gradients) were obtained for each region. Evaluation was performed using threefold cross-validation, such that a subset of studies was used to select the most predictive features, and the remaining subset was used to evaluate their efficacy in predicting survival. RESULTS:A subset of ten radiomic 'peritumoral' MRI features, suggestive of intensity heterogeneity and textural patterns, was found to be predictive of survival (p = 1.47 × 10-5) as compared to features from enhancing tumour, necrotic regions and known clinical factors. CONCLUSION:Our preliminary analysis suggests that radiomic features from the PBZ on routine pre-operative MRI may be predictive of long- versus short-term survival in GBM. KEY POINTS:• Radiomic features from peritumoral regions can capture glioblastoma heterogeneity to predict outcome. • Peritumoral radiomics along with clinical factors are highly predictive of glioblastoma outcome. • Identifying prognostic markers can assist in making personalized therapy decisions in glioblastoma.
journal_name
Eur Radioljournal_title
European radiologyauthors
Prasanna P,Patel J,Partovi S,Madabhushi A,Tiwari Pdoi
10.1007/s00330-016-4637-3subject
Has Abstractpub_date
2017-10-01 00:00:00pages
4188-4197issue
10eissn
0938-7994issn
1432-1084pii
10.1007/s00330-016-4637-3journal_volume
27pub_type
杂志文章abstract::The aim of this study was to evaluate the feasibility of endoluminal stent-graft placement in an angiographic suite for the treatment of emergent type-B aortic dissections and ruptured thoracic aortal aneurysms. Twenty-six patients with either urgent type-B dissection (n=8) or aneurysms (n=18) of the descending thorac...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-1921-9
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Many radiologists and clinicians still consider multiple myeloma (MM) and monoclonal gammopathies (MG) a contraindication for using iodine-based contrast media. The ESUR Contrast Media Safety Committee performed a systematic review of the incidence of post-contrast acute kidney injury (PC-AKI) in these patie...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-017-5023-5
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the automated two-point Dixon screening sequence for the detection and estimated quantification of hepatic iron and fat compared with standard sequences as a reference. METHODS:One hundred and two patients with suspected diffuse liver disease were included in this prospective study. The followin...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3528-8
更新日期:2015-05-01 00:00:00
abstract::To determine whether neutral contrast agents with water-equivalent intraluminal attenuation can improve delineation of the bowel wall and increase overall image quality for a non-selected patient population, a neutral oral contrast agent (3% mannitol) was administered to 100 patients referred for abdominal multidetect...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-0958-1
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery d...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-014-3164-3
更新日期:2014-07-01 00:00:00
abstract::The aim of this study was to present CT findings of occult ureteropelvic junction obstruction in patients with renal trauma and to describe the clinical signs and singular CT features that are characteristically observed with trauma and are relevant to management of these patients. We retrospectively reviewed 82 helic...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050718
更新日期:1999-01-01 00:00:00
abstract::Primary misplaced or secondary flipped implanted catheters are located mostly in the right jugular vein. We demonstrate an effective method to replace fix implanted catheters such as Ports, Grochomg or Hickman catheters. Using a femoral venous approach, replacement into the superior vena cava can easily be done with a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1151-y
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To investigate the optimal imaging delay time of dynamic contrast-enhanced magnetic resonance (MR) imaging in women with endometrial cancer. MATERIALS AND METHODS:This prospective single-institution study was approved by the institutional review board, and informed consent was obtained from the participants. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3327-2
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To evaluate the prognosis of "strict" high-risk nodules (small hepatocellular nodules detected only in the hepatobiliary phase of initial Gd-EOB-DTPA-enhanced MR examination) in patients with cirrhosis or chronic hepatitis. METHODS AND MATERIALS:The study included thirty-three patients with 60 "strict" high-ri...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3293-8
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:X-ray iodinated contrast media have been shown to generate contrast in MR images when used with the chemical exchange saturation transfer (CEST) approach. The aim of this study is to compare contrast enhancement (CE) capabilities and perfusion estimates between radiographic molecules and a Gd-based contrast ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4552-7
更新日期:2017-05-01 00:00:00
abstract::We evaluated an algorithm for automatic selection of the cardiac phase with the least motion for image reconstruction at coronary computed tomography (CT) angiography (CCTA). We analyzed data of 100 patients (49 female, mean age 59 years) who had undergone retrospectively ECG-gated CCTA. Two experienced observers visu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1368-8
更新日期:2009-08-01 00:00:00
abstract::The aim of this study was to analyze the precision of tibial cartilage morphometry, by using a fast, coronal water-excitation sequence with high spatial resolution, to compare the reproducibility of 3D thickness vs volume estimates, and to test the technique in patients with severe osteoarthritis. The tibiae of 8 heal...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050047
更新日期:2000-01-01 00:00:00
abstract::Ultrasound (US) of the paediatric chest has become an established imaging tool that may supplement plain film findings helping to reduce or tailor other ionizing (sectional) imaging in a variety of paediatric conditions such as sequestration or pneumonia. US has been shown to offer valuable imaging alternatives, both ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-007-0754-3
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is characterized by variable contributions of emphysema and airway disease on computed tomography (CT), and still little is known on their temporal evolution. We hypothesized that quantitative CT (QCT) is able to detect short-time changes in a cohort of patients w...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06577-y
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between paraspinal and psoas muscle volumes and acute osteoporotic or low-bone-mass compression fractures of the lumbar spine in postmenopausal women. METHODS:Patient data were retrieved retrospectively for postmenopausal women with L-spine magnetic resonance imaging (MRI) and...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06034-w
更新日期:2019-09-01 00:00:00
abstract:KEY POINT:• The term "pericolic" is wrongly used to describe an abscess adjacent to the colon in patients with acute diverticulitis. We explain why the proper term is the word "paracolic." ...
journal_title:European radiology
pub_type: 信件
doi:10.1007/s00330-018-5827-y
更新日期:2019-08-01 00:00:00
abstract::Whole-body MRI (WB-MRI) has been successfully applied for oncologic and cardiovascular diagnostics, whereas imaging in myopathies usually employs dedicated protocols restricted to areas of specific interest. In this study, we propose a comprehensive neuromuscular WB-MRI protocol. Eighteen patients with degenerative an...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1071-1
更新日期:2008-12-01 00:00:00
abstract::The aim of this study was to validate oxygen-sensitive 3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional 3He-MRI measurements were ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2778-x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Opsoclonus myoclonus ataxia (OMA) syndrome, also known as "Kinsbourne syndrome" or "dancing eye syndrome," is a rare, paraneoplastic entity which may be associated with pediatric neuroblastic tumors and carry a grave prognosis. We aimed to evaluate the role of 68Ga DOTANOC PET/CT for detecting neuroblastic t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07587-x
更新日期:2021-01-06 00:00:00
abstract:OBJECTIVE:To evaluate the risk factors affecting early diffuse recurrence within 1 year of percutaneous ultrasound-guided radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). METHODS:Out of 146 patients who received transcatheter arterial chemoembolisation (TACE) for treatment of recurrent HCC after percu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2561-8
更新日期:2013-01-01 00:00:00
abstract::We present a case of swelling of the eyelid and supraorbital anesthesia caused by an intraorbital tumor. The differential diagnosis based on imaging consisted of aneurysmal bone cyst, schwannoma, neurofibroma, dermoid cyst, and cavernous hemangioma. The surgical and pathological diagnosis was an ancient schwannoma of ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1659-0
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. METHODS:PMCTs were compared with autop...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2779-0
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Image-guided interventional procedures of the nerves are commonly performed by physicians from different medical specialties, although there is a lack of clinical indications for these types of procedures. This Delphi-based consensus provided a list of indications on image-guided interventional procedures fo...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06479-z
更新日期:2020-03-01 00:00:00
abstract::Though long considered unlikely because of the resonance pattern of agents such as SonoVue, high frequency applications for small parts and intracavitary applications now seem very promising. Excellent non-linear signals can be obtained at 7 MHz and higher using recently developed CPS software, and preliminary results...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s10406-004-0084-3
更新日期:2004-10-01 00:00:00
abstract::Skeletal muscle is one of the most unusual sites of metastasis from any malignancy. We report a patient with rapidly progressive contractures due to metastatic infiltration of a carcinoma of unknown origin into the skeletal muscle. This 61-year-old man presented with a 1-month history of rapidly evolving, painful rest...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050657
更新日期:1999-01-01 00:00:00
abstract::Earlier studies have shown that single-energy quantitative computed tomography (SEQCT) is a reliable method for bone mineral density (BMD) measurements in thoracic and lumbar vertebrae. Moreover, SEQCT has proved to be a useful parameter in the selection of appropriate implants in cervical spondylodesis. The aim of th...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050312
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To comprehensively and quantitatively analyse flow and vorticity in the right heart of patients after repair of tetralogy of Fallot (rTOF) compared with healthy volunteers. METHODS:Time-resolved flow-sensitive 4D MRI was acquired in 24 rTOF patients and 12 volunteers. Qualitative flow evaluation was based o...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4186-1
更新日期:2016-10-01 00:00:00
abstract::Obstructive azoospermia represents approximately 10 % of cases of male hypofertility. It is classified according to the volume of ejaculate. When the latter is normal a proximal obstruction is suspected. Scrotal sonography can help to detect dilation of the epididymal head when clinical findings are equivocal. Ejacula...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050258
更新日期:1997-01-01 00:00:00
abstract::The aim of the study was differential evaluation of new and classical sonographic features of benign thyroid nodules and thyroid cancer with three-dimensional gray-scale sonography and evaluation of the effectiveness of the thin-slice surface rendered images in comparison with multiplanar reformation (MPR) presentatio...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2903-x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To assess whether increases in amide proton transfer (APT)-weighted signal reflect the effects of tissue recovery from acidosis using transient rat middle cerebral artery occlusion (MCAO) models, compared to permanent occlusion models. MATERIALS AND METHODS:Twenty-four rats with MCAO (17 transient and seven...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5964-3
更新日期:2019-08-01 00:00:00