The cytotoxic and genotoxic effects of metalaxy-M on earthworms (Eisenia fetida).

Abstract:

:As the main optical isomer of metalaxyl, metalaxyl-M has been widely used worldwide in recent years because of its notable effect on the prevention and control of crop diseases. Together with the toxicity and degradation of metalaxyl-M, the chemical has attracted the attention of researchers. The present study examined the toxic effects of metalaxyl-M on earthworms at 0 mg kg(-1) , 0.1 mg kg(-1) , 1 mg kg(-1) , and 3 mg kg(-1) on days 7, 14, 21 and 28 after exposure. The results showed that metalaxyl-M could cause an obvious increase in the production of reactive oxygen species (ROS) when the concentration was higher than 0.1 mg kg(-1) , which led to lipid peroxidation in earthworms. Metalaxyl-M can induce DNA damage in earthworms, and the level of DNA damage markedly increased with increasing the concentration of metalaxyl-M. Metalaxyl-M also has a serious influence on the activities of antioxidant enzymes, which results in irreversible oxidative damage in cells. The changes of these indicators all indicated that metalaxyl-M may cause cytotoxic and genotoxic effects on earthworms.

journal_name

Environ Toxicol Chem

authors

Liu T,Zhu L,Han Y,Wang J,Wang J,Zhao Y

doi

10.1002/etc.2682

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

2344-50

issue

10

eissn

0730-7268

issn

1552-8618

journal_volume

33

pub_type

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