Glial Fibrillary Acidic Protein (GFAP) as a Mesenchymal marker of Early Hepatic Stellate Cells Activation in Liver Fibrosis in Chronic Hepatitis C Infection.

Abstract:

OBJECTIVE:This study aims to determine expression of Glial Fibrillary Acidic Protein and of Alpha Smooth Muscle Actin (α-SMA) in hepatic stellate cells of CHC cases and their association with stage of fibrosis. METHODS:The study was conducted at Ziauddin University, Clifton Campus during the year 2010-2012. Sixty Chronic Hepatitis C cases were immmunostained using anti α-SMA antibody and anti-GFAP antibody. Semi quantitative scoring in pericentral, periportal and perisinusoidal area of each case was done to assess immunoexpression of each marker. Results : Immunoexpression of GFAP showed significant association with α-SMA. GFAP expression was inversely correlated with progression of fibrosis. Conclusion : GFAP could represent a useful marker for early hepatic stellate cells activation. Follow up biopsies showing decline in GFAP levels may help identify the target group requiring aggressive therapy.

journal_name

Pak J Med Sci

authors

Hassan S,Syed S,Kehar SI

doi

10.12669/pjms.305.5534

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1027-32

issue

5

eissn

1682-024X

issn

1681-715X

journal_volume

30

pub_type

杂志文章
  • Comparison of stool antigen test with gastric biopsy for the detection of Helicobacter Pylori infection.

    abstract:OBJECTIVE:Helicobacter Pylori (H.pylori) is one of the most important causes of dyspepsia and diagnosis can be made by invasive or non-invasive methods. One of the non-invasive methods, H.pylori stool antigen test (HpSA) is simple, fast and relatively inexpensive. According to this view with regard to gastric biopsy as...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.291.2865

    authors: Sharbatdaran M,Kashifard M,Shefaee S,Siadati S,Jahed B,Asgari S

    更新日期:2013-01-01 00:00:00

  • Prevalence and associated risk factors for syphilis in women with recurrent miscarriages.

    abstract:OBJECTIVE:A Cross Sectional population based serological studies was conducted to determine the prevalence and associated risk factors for syphilis women with recurrent miscarriages. METHODS:Patient's 5ml whole blood was collected through venepuncture technique. Data were collected by all women answered a questionnair...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:

    authors: Hussain Laghari A,Sultana V,Hussain Samoo A,Makhija P,Ara J,Hira

    更新日期:2014-03-01 00:00:00

  • Rare cause of bilateral groin swelling: Round ligament varicosities.

    abstract::Round ligament varicosity (RLV) is rare and almost all cases are pregnant women. RLV appears as a unilateral or bilateral groin swelling. Pain and tenderness may present. Clinical evaluation is inadequate for exact diagnosis because inguinal hernia has similar findings. Ultrasonography (US) is essential when a groin s...

    journal_title:Pakistan journal of medical sciences

    pub_type:

    doi:10.12669/pjms.314.7954

    authors: Bulbul E,Taskin MI,Yanik B,Demirpolat G,Adali E,Basbug M

    更新日期:2015-07-01 00:00:00

  • Role of Vitamin D in reducing number of acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients.

    abstract:BACKGROUND AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of th...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.333.12397

    authors: Khan DM,Ullah A,Randhawa FA,Iqtadar S,Butt NF,Waheed K

    更新日期:2017-05-01 00:00:00

  • Incidence of microvascular complications of type 2 diabetes: A 12 year longitudinal study from Karachi-Pakistan.

    abstract:Objectives:To estimate the incidence of microvascular complications among subjects with type 2 diabetes at a tertiary care hospital. Methods:This retrospective longitudinal follow-up study assessed the data records of type 2 diabetic subjects who visited the outpatient department of Baqai Institute of Diabetology and ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.345.15224

    authors: Fawwad A,Mustafa N,Zafar AB,Khalid M

    更新日期:2018-09-01 00:00:00

  • Assessment of work-related Asthma cases: Our three-year experience.

    abstract:Objective:Work-related asthma (WRA) is one of the most common occupational diseases. In this study, we aimed to review diagnosing procedures and the characteristics of patients who were diagnosed with WRA. Methods:Between November 2013 and June 2016; 214 patients were referred to our clinic with WRA suspicion by an oc...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.335.12923

    authors: Beyan AC,Alici NS,Cimrin A

    更新日期:2017-09-01 00:00:00

  • Fetomaternal outcome of pregnancy with Mitral stenosis.

    abstract:OBJECTIVE:To evaluate the frequency of fetomaternal outcome of pregnancy with Mitral stenosis admitted in Civil Hospital Karachi. METHODS:It was a two years descriptive study done in the Department of Obstetrics and Gynaecology Civil Hospital Karachi. All pregnant women with a known or newly diagnosed Mitral stenosis ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.313.7020

    authors: Ahmed N,Kausar H,Ali L,Rakhshinda

    更新日期:2015-01-01 00:00:00

  • Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard.

    abstract:Objective:To evaluate the diagnostic accuracy of ultrasound in obstructive jaundice taking MRCP as gold standard. Methods:This cross-sectional study was conducted at Dow Institute of Radiology (DIR), Dow University of Health Sciences (DUHS), Karachi from 2nd May 2018 till 2nd November 2018. Both male and female patien...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.4.1665

    authors: Hanif H,Khan SA,Muneer S,Adil SO

    更新日期:2020-05-01 00:00:00

  • Status of bone health and association of socio-demographic characteristics with Bone Mineral Density in Pakistani Females.

    abstract:Background & Objective:The "silent thief" of bone osteoporosis is associated with various modifiable factors, identifying these factors is important in decreasing the prevalence of this highly prevalent disease. Therefore, this study was planned to identify these risk factors for osteoporosis in premenopausal and postm...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.3.551

    authors: Tariq S,Baig M,Tariq S,Shahzad M

    更新日期:2019-01-01 00:00:00

  • To compare anti-albumin urea effects of valsartan alone with combination of valsartan and amlodipine in patients of chronic kidney disease.

    abstract:OBJECTIVE:To compare anti-albumin urea effects of Valsartan alone with combination of Valsartan and Amlodipine in patients of chronic kidney disease. METHODS:This randomized clinical trial was conducted at the Department of Medicine, Combined Military Hospital Bahawalpur, from April 2014 to 30 September 2014. 140 pati...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.323.9541

    authors: Ameen,Kashif MA,Sumreen

    更新日期:2016-05-01 00:00:00

  • Advantages, Limitations and Recommendations for online learning during COVID-19 pandemic era.

    abstract:Objective:During COVID-19 pandemic, the institutions in Pakistan have started online learning. This study explores the perception of teachers and students regarding its advantages, limitations and recommendations. Methods:This qualitative case study was conducted from March to April 2020. Using maximum variation sampl...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.COVID19-S4.2785

    authors: Mukhtar K,Javed K,Arooj M,Sethi A

    更新日期:2020-05-01 00:00:00

  • Otomycosis; clinical features, predisposing factors and treatment implications.

    abstract:UNLABELLED:Objectives : The aim of this study was to determine the frequency of otomycosis, the clinical presentation, predisposing factors and treatment outcomes. METHODS:This observational study was conducted at ENT department of Combined Military Hospital Attock, from October, 2010 to September, 2012. Convenient sa...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.303.4106

    authors: Anwar K,Gohar MS

    更新日期:2014-05-01 00:00:00

  • Predictors of serious findings on bi-directional endoscopy in young patients with anemia and GI symptoms.

    abstract:Background and Objective:Iron deficiency anemia (IDA) has been cited as the most common cause of anemia globally. Gastrointestinal (GI) lesions are amongst the common cause of IDA. Endoscopic evaluation is the most effective way to investigate the IDA. The aim of this study was to show the association of alarming GI sy...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.344.14391

    authors: Aslam F,Khalid AB,Siddiqui F,Jadoon Y

    更新日期:2018-07-01 00:00:00

  • Retrosternal Goiter: A couple of classification methods with computed tomograpy findings.

    abstract:Objectives:The retrosternal goiter (RSG), which can be defined by different classification and its incidence between 2% and 26% of all thyroidectomized patients, is a thyroid gland disease. Our aim was to classify RSG cases with a couple of different ways, which we have detected in computed tomography (CT) imaging of t...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.346.15932

    authors: Perincek G,Avci S,Celtikci P

    更新日期:2018-11-01 00:00:00

  • Clinical comparative study on Nitrous Oxide inhalation versus intravenous propofol and Midazolam sedation in Transnasal Gastroscopy.

    abstract:OBJECTIVE:To investigate the Clinical practice value of nitrous oxide inhalation and intravenous propofol and midazolam sedation in transnasal gastroscopy. METHOD:From December 2012 to April 2014, two hundred patients receiving painless transnasal gastroscopy on a voluntary basis were selected in Endoscopy center, The...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.334.12290

    authors: Xiaoqian Z,Tao Z,Bingsong L,Jing L,Yu D,Weilan Z

    更新日期:2017-07-01 00:00:00

  • Hemolysis associated with pneumatic tube system transport for blood samples.

    abstract:OBJECTIVE:The frequency of hemolysis of blood samples may be increased by transport in a pneumatic tube system. The purpose of this study was to evaluate the effect of pneumatic tube system transport on hemolysis of blood samples. METHODS:Blood samples were transported from the emergency department to the hospital lab...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.301.4228

    authors: Kara H,Bayir A,Ak A,Degirmenci S,Akinci M,Agacayak A,Marcil E,Azap M

    更新日期:2014-01-01 00:00:00

  • Short-term clinical effect of conformal radiotherapy combined with tegafur gimeracil oteracil potassium in treating recurrent esophagus cancer.

    abstract:OBJECTIVE:To observe clinical effects of three-dimensional conformal radiotherapy combined with Tegafur Gimeracil Oteracil Potassium chemotherapy in the treatment of patients with recurrent esophagus cancer. METHODS:One hundred and twelve senile patients who suffered from esophagus cancer were selected and randomly di...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.325.10632

    authors: Jiao Y,Shen Y,Yan H,Liu Y,Tan H,Li J

    更新日期:2016-09-01 00:00:00

  • Low dose albumin for the prevention of renal impairment following large volume paracentesis in cirrhosis.

    abstract:OBJECTIVES:To evaluate the effect of low dose Albumin i.e. 4 grams per litre of ascitic fluid after large volume paracentesis (LVP) for the prevention of paracentesis induced circulatory dysfunction (PICD) related renal impairment in cirrhosis. METHODS:Case records of all patients with cirrhosis who underwent LVP from...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.313.7281

    authors: Hussain W,Khalid AB,Usmani T,Ghufran A,Shah H

    更新日期:2015-01-01 00:00:00

  • Comparison between effectiveness of Mechanical and Manual Traction combined with mobilization and exercise therapy in Patients with Cervical Radiculopathy.

    abstract:BACKGROUND AND OBJECTIVE:Cervical radiculopathy is a common neuro-musculo-skeletal disorder causing pain and disability. Traction is part of the evidence based manual physical therapy management due to its mechanical nature, type of traction and parameters related to its applicability and are still to be explored more ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.321.8923

    authors: Bukhari SR,Shakil-Ur-Rehman S,Ahmad S,Naeem A

    更新日期:2016-01-01 00:00:00

  • Perceived stress and monetary burden among thalassemia patients and their caregivers.

    abstract:Objective:To find the perceived stress level and monetary burden in the thalassemia patients and their caregivers related to thalassemia treatment sessions. Methods:A descriptive cross sectional study was conducted at Rawalpindi Thalassemia Centre and Military Hospital Rawalpindi of six months' duration from November ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.344.15420

    authors: Hisam A,Khan NUS,Tariq NA,Irfan H,Arif B,Noor M

    更新日期:2018-07-01 00:00:00

  • Outbreak of Coronavirus Disease 2019 (COVID‑19) in Pakistan: Psychological impact and coping strategies of Health Care Professionals.

    abstract:Objective:This study was conducted to explore factors that can impact psychological health and coping strategies to help health care professionals (HCPs) to perform their duties. Methods:A cross sectional survey was conducted using structured questionnaire electronically shared with the participants after ethical appr...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.7.2988

    authors: Noreen K,Umar M,Sabir SA,Rehman R

    更新日期:2020-11-01 00:00:00

  • Prevalence of Hepatitis B and C virus infection and their co-relation with hematological and hepatic parameters in subjects undergoing Premarital Screening in the Jazan Region, Kingdom of Saudi Arabia.

    abstract:Objective:Hepatitis is a serious health concern with a high rate of mortality and morbidity world over. Saudi Arabia also has its course of the disease incidence. The data on the prevalence of the disease is still limiting. This study aimed to estimate the prevalence of hepatitis B virus [HBV] and hepatitis C virus [HC...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.342.14278

    authors: Abdullah SM

    更新日期:2018-03-01 00:00:00

  • Effect of intralesional 5 fluorouracil injection in primary pterygium.

    abstract:OBJECTIVE:To determine mean change in visual acuity, corneal astigmatism and clinical appearance of pterygium after intralesional injection of 5-Fluorouracil. METHODS:This was a Quasi experimental study conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from June 2014 to May 2015. Total 68 eyes...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.321.8169

    authors: Khan MS,Malik S,Basit I

    更新日期:2016-01-01 00:00:00

  • What gastroenterologists should know during COVID-19 Pandemic!

    abstract::The WHO has declared a Pandemic due to Novel Corona virus-19 (COVID-19). Patients usually have respiratory symptoms but gastrointestinal and hepatic dysfunction are not uncommon presentations and can lead to a delay in diagnosis and management. Virus shedding can continue even after the nasopharyngeal swab gets negati...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.36.COVID19-S4.2651

    authors: Kamani L

    更新日期:2020-05-01 00:00:00

  • Factors affecting mode of delivery in a nullipara at term with singleton pregnancy and vertex presentation (NTSV).

    abstract:OBJECTIVE:To analyse the factors associated with Caesarean Section (CS) of Nulliparous, Term and Singleton pregnancies with Vertex presentation (NTSV) at a tertiary care hospital. METHODS:In this unmatched retrospective case-control study, 212 NTSV patients were identified through computerized medical record systems; ...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.322.9138

    authors: Ahmed I,Chishti U,Akhtar M,Ismail H

    更新日期:2016-03-01 00:00:00

  • Nurses in double trouble: Antecedents of job burnout in nursing profession.

    abstract:Objective:To understand the most prominent factors contributing to job burnout in the nursing profession. Methods:Mixed method design was used in this study. In the qualitative part of the study, a focus group discussion approach was used to determine the major factors contributing in nurses' job burnout. The quantita...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.35.4.600

    authors: Shahzad MN,Ahmed MA,Akram B

    更新日期:2019-07-01 00:00:00

  • The effectiveness of trendelenburg positioning on the cross-sectional area of the right internal jugular vein in obese patients.

    abstract:OBJECTIVE:Trendelenburg positioning is a common approach used during internal jugular vein (IJV) cannulation. No evidence indicates that Trendelenburg positioning significantly increases the cross-sectional area (CSA) of the IJV in obese patients. The primary aim of this study was to determine the effectiveness of Tren...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.314.7326

    authors: Onal O,Apiliogullari S,Nayman A,Saltali A,Yilmaz H,Celik JB

    更新日期:2015-07-01 00:00:00

  • An assessment of knowledge, attitude and practices (KAP) towards diabetes and diabetic retinopathy in a suburban town of Karachi.

    abstract:OBJECTIVE:To assess the Knowledge, Attitude and Practices (KAP) towards diabetes and diabetic retinopathy in the general population of Bin Qasim Town (BQ), Karachi. METHODS:An observational, cross-sectional study was approved by Research Ethical Committee of Al-Ibrahim Eye Hospital. It included every third household b...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.311.6317

    authors: Memon MS,Shaikh SA,Shaikh AR,Fahim MF,N Mumtaz S,Ahmed N

    更新日期:2015-01-01 00:00:00

  • Factors associated with preoperative and postoperative epileptic seizure in patients with cerebral ganglioglioma.

    abstract:OBJECTIVE:To explore the factors associated with preoperative epileptic seizure and surgical outcome in patients with cerebral gangliolioma (GG). METHODS:A total of 31 consecutive patients with pathologically confirmed ganglioglioma and surgically treated from January 2003 to June 2011 in West China Hospital of Sichua...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.302.4362

    authors: Huang C,Li H,Chen M,Si Y,Lei D

    更新日期:2014-03-01 00:00:00

  • The impact of medical insurance policies on the hospitalization services utilization of people with schizophrenia: A case study in Changsha, China.

    abstract:OBJECTIVE:To evaluate the impact of two medical insurers' policies on the hospitalization of people with schizophrenia and the economic burden they faced during a period of rapid health services reform in China. METHODOLOGY:A comparative analysis was made of Urban Employee-Basic Medical Insurance (UE-BMI) and Urban Re...

    journal_title:Pakistan journal of medical sciences

    pub_type: 杂志文章

    doi:10.12669/pjms.293.3273

    authors: Feng Y,Xiong X,Xue Q,Yao L,Luo F,Xiang L

    更新日期:2013-05-01 00:00:00