Abstract：
STUDY OBJECTIVE:To explore the potential occurrence of long-term side effects and tolerability of gonadotropin-releasing hormone agonist (GnRHa) plus 2 different add-back regimens in adolescent patients with endometriosis. DESIGN:Follow-up questionnaire sent in 2016 to patients who participated in a drug trial between 2008 and 2012. SETTING:Tertiary care center in Boston, Massachusetts. PARTICIPANTS:Female adolescents with surgically confirmed endometriosis (n = 51) who enrolled in a GnRHa plus add-back trial as adolescents. INTERVENTIONS:Leuprolide depot 11.25 mg intramuscular injection every 3 months, plus oral norethindrone acetate 5 mg daily or oral norethindrone acetate 5 mg daily and oral conjugated equine estrogens 0.625 mg daily. MAIN OUTCOME MEASURES:Side effects during and after treatment, irreversible side effects, changes in pain, overall satisfaction. RESULTS:The response rate was 61% (25 of 41; 10 subjects could not be located). Almost all (24 of 25) reported side effects during treatment; 80% (16 of 21) reported side effects lasting longer than 6 months after stopping treatment. Almost half (9 of 20) reported side effects they considered irreversible, including memory loss, insomnia, and hot flashes. Despite side effects, participants rated GnRHa plus add-back as the most effective hormonal medication for treating endometriosis pain; two-thirds (16 of 25) would recommend it to others. More participants who received a modified 2-drug add-back regimen vs standard 1-drug add-back would recommend GnRHa and believed it was the most effective hormonal medication. CONCLUSION:Subjects believed that GnRHa used with add-back was effective and would recommend it to others, despite significant side effects. Those who received 2-drug add-back reported more success than those who received standard add-back. A subset of patients reported side effects they consider to be irreversible.
journal_name
J Pediatr Adolesc Gynecoljournal_title
Journal of pediatric and adolescent gynecologyauthors
Gallagher JS,Missmer SA,Hornstein MD,Laufer MR,Gordon CM,DiVasta ADdoi
10.1016/j.jpag.2018.03.004subject
Has Abstractpub_date
2018-08-01 00:00:00pages
376-381issue
4eissn
1083-3188issn
1873-4332pii
S1083-3188(18)30181-5journal_volume
31pub_type
杂志文章,随机对照试验abstract：UNLABELLED:STUDY OBJECTIVES AND DESIGN: This descriptive study assessed background characteristics and attitudes about pregnancy held by adolescent girls presenting for pregnancy tests and receiving negative results. An additional aim was to determine types of health care services that would be of perceived benefit to ...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2005.05.005
更新日期：2005-08-01 00:00:00
abstract：STUDY OBJECTIVE:To investigate the racial/ethnic differences in the correlates of spontaneous and medically-indicated late preterm birth (LPTB), defined as deliveries between 34 0/7 and 36 6/7 weeks gestation, among US adolescents. DESIGN:Population-based, retrospective cohort study. SETTING:Births in the United Stat...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2016.08.004
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to identify trends in the clinical workup, diagnosis, and treatment of polycystic ovary syndrome by pediatric endocrinologists, pediatric gynecologists, and adolescent medicine specialists. DESIGN:Retrospective chart review. SETTING:Tertiary care medical center. PARTICIPANTS:Fe...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2014.03.002
更新日期：2015-02-01 00:00:00
abstract：STUDY OBJECTIVE:We assessed factors that might affect perinatal outcomes in second pregnancies in adolescents. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, MAIN OUTCOME MEASURES: This longitudinal retrospective study was carried out on 66 adolescents who experienced 2 deliveries during their adolescence. Data were col...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2015.05.002
更新日期：2016-02-01 00:00:00
abstract：STUDY OBJECTIVE:Congenital uterine anomalies are common, although the majority are asymptomatic. When an obstructed system exists, women may present with abdominal pain, or dysmenorrhea. Removal of the obstructed horn may be required in the symptomatic patient. In the past, surgical treatment necessitated a laparotomy....
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2006.08.003
更新日期：2007-06-01 00:00:00
abstract：STUDY OBJECTIVE:To identify demographic and relationship characteristics associated with paternity establishment for children born to adolescent mothers. PARTICIPANTS, SETTING, AND DESIGN: This prospective cohort study included 300 pregnant adolescents 12-19 years old, presenting for prenatal care between March 2002 an...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2012.05.015
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abstract：STUDY OBJECTIVE:The objective of this study was to evaluate the quality and accuracy of sexual health information on crisis pregnancy center Web sites listed in state resource directories for pregnant women, and whether these Web sites specifically target adolescents. DESIGN:A survey of sexual health information prese...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2015.05.008
更新日期：2016-02-01 00:00:00
abstract：STUDY OBJECTIVE:The purpose of this study was to understand how health care providers use and distribute oral contraceptive pill (OCP) sample packs to adolescents. DESIGN:Qualitative study involving face-to-face structured interviews. SETTING:Interviews lasted approximately 20-30 minutes and were done in the health c...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/s1083-3188(00)00046-2
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abstract：PURPOSE:Pregnancy prevention counseling addresses future goals as a motivator for contraceptive use, but this is often unsuccessful. This study investigated how adolescent females define success and whether they believe teen childbearing will be a barrier to their success. METHODS:A racially and ethnically diverse gro...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2013.12.009
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Advances in radiation therapy have led to long term survival in young patients with Hodgkin's disease. Oophoropexy may reduce ovarian damage and preserve hormonal production and future fertility. When ovarian ligaments are shortened, incising the serosa parallel to the infundibulopelvic ligaments at laparosc...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2005.06.009
更新日期：2005-10-01 00:00:00
abstract：STUDY OBJECTIVE:This study was undertaken to assess the causes and treatments of menorrhagia in adolescents hospitalized for this menstrual disorder. DESIGN:A retrospective chart review was performed of all adolescents < or =20 years of age with menorrhagia admitted at the University of Michigan from 1979 to 1995. Inf...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/s1083-3188(98)70101-9
更新日期：1998-02-01 00:00:00
abstract：STUDY OBJECTIVE:To assess the effect of providing standardized counseling to improve the rates of contraception initiation and utilization among detained young women. This was a quality improvement (QI) project conducted at a large urban juvenile short-term detention center. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2018.01.002
更新日期：2018-08-01 00:00:00
abstract：STUDY OBJECTIVES:To determine the impact of antiandrogen treatment on bone density and geometry. DESIGN:Prospective cohort investigation. SETTING:Academic research institute. PARTICIPANTS:38 (age 14.96 ± 1.42 yr) subjects with PCOS. INTERVENTIONS:Treated with metformin (n = 17) or metformin and antiandrogen (n = 21...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2011.11.010
更新日期：2012-06-01 00:00:00
abstract：STUDY OBJECTIVES:To assess the effectiveness of fennel on primary dysmenorrhea symptoms and menorrheal duration. DESIGN:Clinical trial study. SETTING:Islamic Azad University, Toyserkan. PARTICIPANTS:80 female students were randomly divided in to two groups of intervention (n = 40) and control (n = 40). INTERVENTION...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpag.2013.12.003
更新日期：2014-10-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the utility of transabdominal ultrasound and magnetic resonance imaging in the evaluation of American Society for Reproductive Medicine (†)(ASRM)-classified müllerian anomalies compared to surgical findings in the pediatric and adolescent population. DESIGN:Retrospective chart review. SETT...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2011.12.069
更新日期：2012-06-01 00:00:00
abstract：:The concept of the ovarian cycle as a continuum considers that all types of ovarian activity encountered during the reproductive life are responses to different environmental conditions in order to ensure the health of the woman. During the normal ovulatory cycle, a series of sequential events have to occur in a highl...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2006.02.003
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Although paratubal cysts are common, borderline paratubal cysts are extremely rare. We describe the case of a large borderline paratubal cyst in a 17-year-old adolescent female treated with laparo-endoscopic single-site surgery (LESS), and review the literature. CASE:A 17-year-old female was referred due to...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2014.07.012
更新日期：2016-02-01 00:00:00
abstract：STUDY OBJECTIVE:Education materials detailing fertility preservation options geared towards pediatric oncology patients are inadequately available, particularly materials that are culturally tailored. An English language pediatric fertility preservation brochure was developed in 2011, and given the significance of fami...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2013.10.004
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:To assess resident physicians' clinical recognition skills in Pediatric and Adolescent Gynecology. MATERIALS:1) A questionnaire to identify demographic data and self-assessment as to the ability to perform a gynecologic evaluation of children. 2) Twenty color photographs of normal genitalia and common gynecolo...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
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abstract：STUDY OBJECTIVE:Human papillomavirus (HPV), the most common sexually transmitted infection in the United States, can be contracted by young girls shortly after sexual debut. Human papillomavirus can lead to cervical and anogenital cancers and genital warts. A vaccine has been developed to protect against precancerous l...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2008.09.002
更新日期：2009-08-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the incidence of hemostatic disorders in a population of adolescents with various patterns of abnormal uterine bleeding (AUB). DESIGN:Retrospective observational study. SETTING:University hospital. PARTICIPANTS:One hundred thirteen adolescents with AUB; mean age at menarche and mean age a...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2013.06.003
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Breast cancer is rare in adolescents. In one study, breast carcinoma accounted for 0.02% of breast masses surgically removed in young women. We report a case of breast cancer in a 19-year-old woman who was found to have Li-Fraumeni Syndrome. CASE:The patient presented with a new, hard, nonmobile lump in the...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2016.08.011
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Skene's glands are believed to be homologues of the prostate gland derived from the urogenital sinus.(1) Complications of Skene's glands occur most often in the third and fourth decades and are rarely seen in premenarchal females. CASE:A 3-year-old presented to her pediatrician with a 9-day complaint of vul...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2007.11.004
更新日期：2009-02-01 00:00:00
abstract：:Tattoo rates in the United States have been rising in recent years, with an expected concomitant rise in tattoo-associated complications. Tattoo complications range from cutaneous localized and generalized inflammatory eruptions, to local bacterial or viral infections, and finally to infectious endocarditis and hepati...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2012.08.005
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:There are many hypotheses regarding the pathogenesis of endometriosis. Most theories, including retrograde menstruation, require the existence of a uterine structure and endometrial tissue. We report endometriosis with the absence of a uterus. This finding supports the theory of coelomic metaplasia. CASE:A ...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2009.02.010
更新日期：2010-02-01 00:00:00
abstract：STUDY OBJECTIVE:To describe the sociodemographic characteristics of a cohort of adolescents undergoing loop electrosurgical excision procedure (LEEP) of the cervix, and to determine if LEEP is a safe and effective procedure for evaluation and treatment of high-grade squamous intraepithelial lesions (HSIL) of the cervix...
journal_title：Journal of pediatric and adolescent gynecology
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abstract：STUDY OBJECTIVE:Amphiregulin is a member of the epidermal growth factor family. In breast tissue, amphiregulin is a mediator of estrogen and progesterone signaling. The objectives were to examine the relationship of amphiregulin levels during peripuberty with estrogen levels. DESIGN, SETTING, PARTICIPANTS, INTERVENTION...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Neisseria gonorrhoeae is one of the most common organisms associated with pelvic disease in a woman of reproductive age. CASE:We present an unusual case of cerebrospinal fluid infection with N. gonorrhoeae in a woman with a ventriculoperitoneal shunt who complained of abdominal pain. Her shunt was removed a...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/s1083-3188(97)70059-7
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Pyometra is an uncommon but serious condition that is generally diagnosed in postmenopausal women. It rarely occurs in premenopausal patients, particularly adolescents. CASE:A 16-year-old girl with multiple comorbidities including severe intellectual disability, neurogenic bladder, and recurrent urinary tra...
journal_title：Journal of pediatric and adolescent gynecology
pub_type：
doi：10.1016/j.jpag.2020.06.009
更新日期：2020-10-01 00:00:00
abstract：STUDY OBJECTIVE:To report results of a retrospective multicentric Italian survey concerning the management of pediatric ovarian torsion (OT) and its recurrence. DESIGN:Multicenter retrospective cohort study. SETTING:Italian Units of Pediatric Surgery. PARTICIPANTS:Participants were female aged 1-14 years of age with...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpag.2016.11.008
更新日期：2017-06-01 00:00:00
