Abstract：
STUDY OBJECTIVES:To determine the impact of antiandrogen treatment on bone density and geometry. DESIGN:Prospective cohort investigation. SETTING:Academic research institute. PARTICIPANTS:38 (age 14.96 ± 1.42 yr) subjects with PCOS. INTERVENTIONS:Treated with metformin (n = 17) or metformin and antiandrogen (n = 21). MAIN OUTCOME MEASURE:Bone density and geometry parameters at baseline and after a mean duration of 1.92 ± 0.88 years using peripheral quantitative computed tomography of the forearm. RESULTS:At baseline, z-scores for trabecular (0.53 ± 1.02) and cortical BMD (0.79 ± 1.55) as well as total (0.62 ± 1.07) and medullary cross sectional area (CSA) (0.79 ± 1.29) were elevated. Cortical CSA (-0.01 ± 1.10) and bone strength strain index (SSI) z-scores (-0.01 ± 1.10) were normal. Muscle CSA z-score (0.12 ± 1.70) was normal, but grip strength (-1.60 ± 1.15) was significantly reduced. There were no significant changes within and between the two treatment options in respect to bone density and bone geometry parameters. With antiandrogen treatment, free androgen index (FAI) was significantly lower and grip strength further decreased (P < .001). CONCLUSIONS:No significant changes in bone mineral density and geometry parameters took place in PCOS women irrespective of treatment followed over a time of almost two years. General muscle weakness expressed as low grip strength may influence further bone development in PCOS.
journal_name
J Pediatr Adolesc Gynecoljournal_title
Journal of pediatric and adolescent gynecologyauthors
Bechtold S,Dalla Pozza R,Putzker S,Roeb J,Buckel M,Weissenbacher C,Schmidt Hdoi
10.1016/j.jpag.2011.11.010subject
Has Abstractpub_date
2012-06-01 00:00:00pages
175-80issue
3eissn
1083-3188issn
1873-4332pii
S1083-3188(11)00467-0journal_volume
25pub_type
杂志文章abstract：OBJECTIVE:To prospectively identify psychosocial predictors of pregnancy among African-American adolescent females. METHODS:African-American females, 14-18 yrs old, were recruited from schools and health clinics in low-income neighborhoods. Adolescents completed an in-depth survey and provided urine specimens for preg...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/s1083-3188(02)00195-x
更新日期：2002-12-01 00:00:00
abstract：STUDY OBJECTIVE:In this study, we aimed to determine the frequency of menstrual history and sexual history documentation in the inpatient setting. DESIGN, SETTING, AND PARTICIPANTS:A retrospective chart review was conducted for 307 female patients ages 11-18 years admitted from the emergency department at a single ins...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2019.05.007
更新日期：2019-10-01 00:00:00
abstract：STUDY OBJECTIVE:Recent data show US adolescents are engaging in sexual activity at earlier ages; however, little is known about young teens' sexual attitudes and behaviors. Examining teens' questions in sex education classes may provide insight into these attitudes and behaviors. DESIGN:Quasi cohort study SETTING:Par...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2008.03.005
更新日期：2008-10-01 00:00:00
abstract：STUDY OBJECTIVE:To describe and evaluate a Canadian simulation session designed to teach pediatric and adolescent gynecology (PAG) history taking, examination and operative skills, and an approach to the child and adolescent. DESIGN:Obstetrics and gynecology residents in a single academic center participated in a PAG ...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2014.01.105
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Gastroschisis is an abdominal wall defect through which the bowel herniates into the amniotic cavity. Surgical correction of gastroschisis is performed during infancy. Gynecologic concerns have not been described in this population as either an associated anomaly or complication of surgical repair. CASE:A 1...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2018.04.005
更新日期：2018-10-01 00:00:00
abstract：:The clinical setting of pediatric and adolescent gynecology poses complex tasks for the physician with its numerous procedures and the communication demands of interacting with an adolescent and/or guardian. Needless to say, teaching within this setting is highly demanding. Regardless of the level of learner or the pr...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2013.09.013
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:A rare disorder of sex development is 45,X/46,XY mosaicism, which is phenotypically very heterogenous, ranging from normal male (or female) to that of genital ambiguity of varying degrees. CASE:We report a case of a neonate with 45,X/46,XY mosaicism and hydrocolpos, and we point out the dilemma and the diff...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2018.09.001
更新日期：2019-02-01 00:00:00
abstract：STUDY OBJECTIVE:To identify demographic and relationship characteristics associated with paternity establishment for children born to adolescent mothers. PARTICIPANTS, SETTING, AND DESIGN: This prospective cohort study included 300 pregnant adolescents 12-19 years old, presenting for prenatal care between March 2002 an...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2012.05.015
更新日期：2012-10-01 00:00:00
abstract：STUDY OBJECTIVE:Topical microbicides are being developed to provide an alternative method of prevention of HIV and sexually transmitted infections. Although topical microbicides would be a female-controlled method of prevention, their use is likely to be disclosed to partners. Thus, the characteristics of the partner r...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2009.02.003
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:The purpose of this paper is to further describe prepubertal distal longitudinal vaginal folds and its natural history. DESIGN:Biopsy of the folds and follow-up through puberty. RESULTS:Histology of the folds shows normal vaginal mucosa over loose fibrous connective tissue without a firm fibrous core. The f...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2007.10.001
更新日期：2008-12-01 00:00:00
abstract：STUDY OBJECTIVE:To assess the effect of providing standardized counseling to improve the rates of contraception initiation and utilization among detained young women. This was a quality improvement (QI) project conducted at a large urban juvenile short-term detention center. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2018.01.002
更新日期：2018-08-01 00:00:00
abstract：STUDY OBJECTIVE:To characterize menstrual health issues and their effect in young women with Angelman syndrome (AS). Our secondary objective was to compare them with young women with autism spectrum disorders (ASDs). DESIGN:Cross-sectional convenience sample survey. SETTING:An institutional review board-approved Web-...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2015.12.004
更新日期：2016-08-01 00:00:00
abstract：STUDY OBJECTIVE:Identify correlates of contraceptive discontinuation, which if modified, might make teenagers more, not less, effective contraceptors as they age. SETTING:Teen clinic. PARTICIPANTS:Teenagers who used contraception at first intercourse (N = 120). Some "never" used contraception during the 4 months imme...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2007.01.004
更新日期：2007-04-01 00:00:00
abstract：:In this article we review the existing fertility preservation options for women diagnosed with Turner syndrome and provide practical guidelines for the practitioner. Turner syndrome is the most common sex chromosome abnormality in women, occurring in approximately 1 in 2500 live births. Women with Turner syndrome are ...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2015.10.011
更新日期：2016-10-01 00:00:00
abstract：STUDY OBJECTIVE:To investigate an association between pubertal development and timing of menarche with glycemic control, disease duration, and body mass index (BMI) in patients diagnosed with diabetes mellitus type 1 (DM1) before puberty. DESIGN:Retrospective study. SETTING:The study was performed at the diabetes out...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2014.08.009
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Recurrent adnexal torsion rarely affects girls. Various surgical techniques for its prevention are available. We describe a case of recurrent asynchronous bilateral torsions in a prepubertal patient. CASE:An 8-year-old girl first presented with a right adnexal torsion and underwent a laparoscopic untwisting...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2013.01.060
更新日期：2013-06-01 00:00:00
abstract：STUDY OBJECTIVE:Cervical cancer morbidity and mortality are pressing public health issues that affect women in Haiti. To inform efforts to develop a human papillomavirus (HPV) vaccination program in Haiti, we sought to understand HPV awareness and willingness to get HPV vaccination in Haiti. DESIGN, SETTING, AND PARTI...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2016.07.003
更新日期：2017-02-01 00:00:00
abstract：:The low rates of actual contraceptive failure and high rates of contraceptive use among young women highlights that choice of contraceptive method and patterns of contraceptive use greatly influence unintended pregnancy risk. Promoting contraceptive use among adolescent and young adult women requires supportive health...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2020.12.008
更新日期：2020-12-14 00:00:00
abstract：STUDY OBJECTIVE:The purpose of the study was to determine if barriers in rural areas might decrease an adolescent's likelihood of obtaining effective contraception. Previous studies have reported mixed results in comparisons of rural and urban contraception use. DESIGN:Electronic survey. SETTING:Midwestern Public Uni...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2015.06.002
更新日期：2016-02-01 00:00:00
abstract：STUDY OBJECTIVES:To report a rare reason for primary amenorrhea, a Frasier syndrome, XY gonadal dysgenesis associated with renal failure with eventual development of gonadoblastoma. To study immunohistochemical analysis of gonadoblastoma and dysgerminoma. To analyze the possibility of androgen receptor mutation in this...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/s1083-3188(02)00147-x
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:Despite hypothesized relationships between lack of partner support during a woman's pregnancy and adverse birth outcomes, few studies have examined partner support among teens. We examined a potential proxy measure of partner support and its impact on adverse birth outcomes (low birth weight (LBW), preterm birt...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2013.08.002
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:To review the etiologies, diagnosis, and treatment options of adolescent endometriosis. METHODS:Review of publications relating to adolescent endometriosis. RESULTS:Endometriosis occurs in adolescents as young as 8 years of age; furthermore, there have been documented cases of endometriosis occurring prior...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/s1083-3188(03)00066-4
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:To preliminarily study the feasibility of oocyte cryopreservation in postpubertal girls aged between 13 and 15 years who were at risk for premature ovarian failure due to the accelerated follicle loss associated with Turner syndrome or cancer treatments. DESIGN:Retrospective cohort and review of literature. ...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2014.01.003
更新日期：2014-12-01 00:00:00
abstract：STUDY OBJECTIVE:We assessed factors that might affect perinatal outcomes in second pregnancies in adolescents. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, MAIN OUTCOME MEASURES: This longitudinal retrospective study was carried out on 66 adolescents who experienced 2 deliveries during their adolescence. Data were col...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2015.05.002
更新日期：2016-02-01 00:00:00
abstract：STUDY OBJECTIVE:To characterize Müllerian anatomy in 46,XX cloacal exstrophy patients. DESIGN:Retrospective review of prospectively maintained, institutionally approved exstrophy-epispadias-cloacal exstrophy database. SETTING:Tertiary care, high-volume exstrophy center (Division of Pediatric Urology, The Johns Hopkin...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2016.01.124
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Uterovaginal prolapse in adolescents is rare, hence this report. CASE:Miss O.N. was a 17-year-old Para 1(+0) A1. She had a regular menstrual cycle. She presented with complaints of mass protruding from her vagina of twenty months duration. The problem started four months after a normal delivery at a materni...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2007.03.099
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Imperforate hymen, with an incidence between 0.1% and 0.05%, is the most common obstructive congenital abnormality of the female genital tract. 'Standard' surgical treatment of imperforate hymen involves hymenectomy after a cruciate, plus, or X-shaped hymenotomy incision. CASES:Two cases with imperforate hy...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2008.03.009
更新日期：2009-08-01 00:00:00
abstract：:Tattoo rates in the United States have been rising in recent years, with an expected concomitant rise in tattoo-associated complications. Tattoo complications range from cutaneous localized and generalized inflammatory eruptions, to local bacterial or viral infections, and finally to infectious endocarditis and hepati...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章
doi：10.1016/j.jpag.2012.08.005
更新日期：2013-04-01 00:00:00
abstract：STUDY OBJECTIVE:Intrauterine device (IUD) utilization in the United States is low among adolescent and young adult women. Longer procedure duration has been proposed as one potential barrier to IUD insertion in this population. We hypothesized that procedure duration would be longer in adolescents compared to young adu...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpag.2019.01.002
更新日期：2019-06-01 00:00:00
abstract：:Adolescents are at high risk of acquiring and becoming reinfected with sexually transmitted infections. Partner notification and treatment are essential to preventing the spread of sexually transmitted infections. Expedited partner therapy (EPT) is a method of partner treatment used by medical providers to treat patie...
journal_title：Journal of pediatric and adolescent gynecology
pub_type： 杂志文章,评审
doi：10.1016/j.jpag.2017.01.012
更新日期：2017-06-01 00:00:00
