Pubertal development in children diagnosed with diabetes mellitus type 1 before puberty.

Abstract:

STUDY OBJECTIVE:To investigate an association between pubertal development and timing of menarche with glycemic control, disease duration, and body mass index (BMI) in patients diagnosed with diabetes mellitus type 1 (DM1) before puberty. DESIGN:Retrospective study. SETTING:The study was performed at the diabetes outpatient clinic of Instituto de Puericultura e Pediatria Martagão Gesteira--IPPMG of the Federal University of Rio de Janeiro--UFRJ. PARTICIPANTS:A total of 131 children, 61 girls and 70 boys, diagnosed with DM1 before puberty participated in the study. MAIN OUTCOME MEASURES:The study investigated how age at puberty onset relates to mean glycated hemoglobin (HbA1c) before puberty, BMI percentile, and disease duration; how puberty duration relates to mean HbA1c before and during puberty and to disease duration; and how timing of menarche relates to mean HbA1c before puberty, BMI percentile, and disease duration. RESULTS:Age at puberty onset was positively correlated with mean HbA1c before puberty (r = 0.204, R(2) = 0.042; P = .019) and disease duration (r = 0.451, R(2) = 0.203; P < .0001), and negatively correlated with BMI percentile (r = -0.289, R(2) = 0.084; P = .001). Timing of menarche was negatively correlated with BMI percentile (r = -0.556, R(2) = 0.310; P < .001). CONCLUSIONS:Children with longer disease duration began puberty later than those diagnosed more recently. Girls in higher BMI percentiles reached menarche sooner.

authors

Pereira KC,Pugliese BS,Guimarães MM,Gama MP

doi

10.1016/j.jpag.2014.08.009

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

66-71

issue

1

eissn

1083-3188

issn

1873-4332

pii

S1083-3188(14)00307-6

journal_volume

28

pub_type

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