Combined abuse of clonidine and amitriptyline in a patient on buprenorphine maintenance treatment.

Abstract:

:Buprenorphine/naloxone maintenance therapy is often prescribed in primary care to treat opioid dependence. Previous reports have described concomitant abuse of opioids and clonidine. In this case, a primary care patient on buprenorphine/naloxone maintenance therapy demonstrating altered mental status, hallucinations, falls, and rebound hypertension was found to be concomitantly abusing clonidine and amitryptyline, which share metabolic pathways with buprenorphine. Clinicians should be aware of patients' combining amitryptyline, clonidine, and gabapentin with buprenorphine to achieve a mood altering state, avoid co-prescribing them if possible, and maintain communication with pharmacies and other providers when they are prescribed.

journal_name

J Addict Med

authors

Seale JP,Dittmer T,Sigman EJ,Clemons H,Johnson JA

doi

10.1097/ADM.0000000000000081

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

476-8

issue

6

eissn

1932-0620

issn

1935-3227

journal_volume

8

pub_type

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