Landiolol: A Review in Tachyarrhythmias.

abstract：:Brexpiprazole (Rexulti®) is an atypical antipsychotic that has been developed by Otsuka Pharmaceutical Co. Ltd and H. Lundbeck A/S as an oral treatment for several psychiatric disorders. Brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1A (5-HT1A) and dopamine ...

journal_title：Drugs

authors： Greig SL

更新日期：2015-09-01 00:00:00

abstract：:Oral zonisamide (Zonegran(®)) is a benzisoxazole derivative chemically unrelated to other antiepileptic agents. It is indicated in the EU as monotherapy in the treatment of partial seizures, with or without secondary generalization, in adults with newly diagnosed epilepsy and as adjunctive therapy to other antiepilept...

journal_title：Drugs

authors： Hoy SM

更新日期：2013-08-01 00:00:00

abstract：:The allergic reaction to a specific antigen is characterised by a series of complex immunological processes consisting of an early specific immune response and a late inflammatory reaction. The release of active substances (principally histamine) from cytoplasmic granules of mast cells and basophils in response to ant...

journal_title：Drugs

authors： Buendia E

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Authorization of orphan medicinal products (OMPs) is often based on studies with several methodological shortcomings. Hence, data are difficult to interpret and efficacy does not always correspond to real-world effectiveness. We investigated to what extent an efficacy-effectiveness gap exists for OMPs for ...

journal_title：Drugs

authors： Schuller Y,Hollak CEM,Gispen-de Wied CC,Stoyanova-Beninska V,Biegstraaten M

更新日期：2017-09-01 00:00:00

abstract：:The efficacy of cilazapril monotherapy was evaluated in 2 multicentre double-blind dose-response trials. After 4 weeks of a single-blind placebo run-in period, patients with uncomplicated mild to moderate essential hypertension and a sitting diastolic blood pressure of 100 to 115 mm Hg, 24 hours after the last placebo...

journal_title：Drugs

authors： Kobrin I,Güntzel P,Viskoper R,Paran E,Zimlichman R

更新日期：1991-01-01 00:00:00

abstract：:Peripheral arterial occlusive disease is a common condition with possible serious consequences. It is usually diagnosed at the intermittent claudication stage. There are 2 objectives of treatment: to prevent ischaemic attacks and to improve quality of life. Treatment efficacy is, however, usually evaluated only in ter...

journal_title：Drugs

authors： Marquis P

更新日期：1998-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have bro...

journal_title：Drugs

authors： Seiler T,Hutter G,Dreyling M

更新日期：2016-04-01 00:00:00

abstract：:Sacituzumab govitecan (sacituzumab govitecan-hziy; Trodelvy™) is a Trop-2-directed antibody conjugated to a topoisomerase I inhibitor (SN-38) that is being developed by Immunomedics for the treatment of solid tumours, including breast cancer. In April 2020, sacituzumab govitecan received accelerated approval in the US...

journal_title：Drugs

authors： Syed YY

更新日期：2020-07-01 00:00:00

abstract：:Kaposi's sarcoma is the most common malignancy associated with HIV infection, and the morbidity and mortality attributable to AIDS-related Kaposi's sarcoma (AIDS-KS) may be increasing. No curative therapy is available for AIDS-KS, but palliative therapy can eliminate or reduce cosmetically unacceptable lesions, reduce...

journal_title：Drugs

authors： Northfelt DW

更新日期：1994-10-01 00:00:00

abstract：:Nadroparin calcium is a low molecular weight heparin with a mean molecular weight of 4.5 kD. Compared with unfractionated heparin, nadroparin calcium has a greater ratio of anti-factor Xa/anti-factor IIa activity. Nadroparin calcium has a longer half-life and greater bioavailability than unfractionated heparin and can...

journal_title：Drugs

authors： Barradell LB,Buckley MM

更新日期：1992-11-01 00:00:00

abstract：UNLABELLED:Patients with beta-thalassaemia and other transfusion-dependent diseases develop iron overload from chronic blood transfusions and require regular iron chelation to prevent potentially fatal iron-related complications. The only iron chelator currently widely available is deferoxamine, which is expensive and ...

journal_title：Drugs

authors： Barman Balfour JA,Foster RH

更新日期：1999-09-01 00:00:00

abstract：:Cibenzoline is a class I antiarrhythmic drug with limited class III and IV activity which can be administered orally or intravenously. An elimination half-life of about 8 to 12 hours permits twice daily administration, although age and renal function must be considered when determining dosage. Cibenzoline has some act...

journal_title：Drugs

authors： Harron DW,Brogden RN,Faulds D,Fitton A

更新日期：1992-05-01 00:00:00

abstract：:Advances over the past 2 decades in our understanding of the biology of panic disorder have paralleled a remarkable increase in the development of new pharmacological agents with antipanic effects. Although we can not presently use biological tests to help with our choice of therapeutic agent for individual patients, ...

journal_title：Drugs

authors： Johnson MR,Lydiard RB,Ballenger JC

更新日期：1995-03-01 00:00:00

abstract：:Four medicinal cancer biological blockbusters will end their patent lifespan by 2020. It is estimated that the total market for cancer biologicals will reach approximately US$68 billion at that time. Approximately 20 biosimilars have entered the European market since the launch of the original approval guidelines in 2...

journal_title：Drugs

authors： Camacho LH

更新日期：2017-06-01 00:00:00

abstract：:The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol syrup (10 m...

journal_title：Drugs

authors： Polidori G,Titti G,Pieragostini P,Comito A,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:The endothelium is involved in both the physiological regulation of vascular tone and the structural transformation of the vessel under pathological conditions. Under physiological conditions, endothelial cells continuously secrete nitric oxide (NO), which relaxes smooth muscle cells and ensures vessel patency. Damage...

journal_title：Drugs

authors： Haller H

更新日期：1997-01-01 00:00:00

abstract：:Acute myocardial infarction (AMI) recognises no boundaries, and the patient's greatest need occurs at the interface between primary care and hospital system. Ideally, the general practitioner, if summoned, should be able to provide resuscitation, analgesia with opiates, and thrombolytic therapy. Thrombolytics should c...

journal_title：Drugs

authors： Rawles J

更新日期：1995-10-01 00:00:00

abstract：:Despite remarkable advances in cardiovascular therapeutics, sudden cardiac death remains a significant problem. In this review, data from clinical trials and other studies on antiarrhythmic therapies have been evaluated in order to determine effective strategies for the prevention of sudden cardiac death in high risk ...

journal_title：Drugs

authors： McAlister FA,Teo KK

更新日期：1997-08-01 00:00:00

abstract：:Zimelidine is a new antidepressant, which is structurally unrelated to the tricyclic and tetracyclic antidepressants. The pharmacological profile of zimelidine is different to that of other antidepressants in that it appears to owe the major part of its activity to the inhibition of serotonin uptake within the central...

journal_title：Drugs

authors： Heel RC,Morley PA,Brogden RN,Carmine AA,Speight TM,Avery GS

更新日期：1982-09-01 00:00:00

abstract：:Trigeminal neuralgia is a representative neuropathic facial pain condition, characterised by unilateral paroxysmal pain in the distribution territory of one or more divisions of the trigeminal nerve, triggered by innocuous stimuli. A subgroup of patients with trigeminal neuralgia [TN (previously defined as atypical TN...

journal_title：Drugs

authors： Di Stefano G,Truini A,Cruccu G

更新日期：2018-09-01 00:00:00

abstract：:Pancreatic islet transplantation as a cell-based treatment for diabetes mellitus has been pursued for over quarter of a century, ever since the first successful use of this approach to cure diabetes mellitus in rodents in the 1970s. However, even though autoislet intrahepatic transplantation in patients with chronic p...

journal_title：Drugs

authors： Robertson RP

更新日期：2001-01-01 00:00:00

abstract：:Developments in drug delivery technology have expanded the formulations of 5-aminosalicylic acid (5-ASA) available to clinicians over the last 50 years. Delivery of adequate doses of 5-ASA to the colon can be achieved by pH-dependent, delayed-release or pro-drug formulations. Despite some variations in the pharmacokin...

journal_title：Drugs

authors： Fernandez-Becker NQ,Moss AC

更新日期：2008-01-01 00:00:00

abstract：:Follicular lymphoma (FL), the most common subtype of indolent lymphoma, is usually diagnosed at an advanced stage (III-IV), although patients are often asymptomatic. Traditionally, a palliative approach to management has been taken, cycling through watchful waiting, radiotherapy, oral alkylating agents and, eventually...

journal_title：Drugs

authors： Pettengell R

更新日期：2009-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease that ultimately leads to disability and functional decline. Because patients usually develop RA in mid-life, they may experience its consequences for 20-30 years or longer. Proinflammatory cytokines, notably interleukin (IL)-1 and tumour necro...

journal_title：Drugs

authors： Schiff MH

更新日期：2004-01-01 00:00:00

abstract：:Tuberculosis continues to be a major cause of disease and death throughout the developing world. Chemotherapy is the current method of control but with the continuing emergence of drug resistance, coupled with the reticence of major drug companies to invest in drug discovery, the identification of new vaccines to comb...

journal_title：Drugs

authors： Orme IM

更新日期：2005-01-01 00:00:00

abstract：:Several large-scale clinical trials have assessed the efficacy of atorvastatin in the primary and secondary prevention of cardiovascular events in patients with diabetes mellitus and/or metabolic syndrome. In primary prevention, CARDS (Collaborative Atorvastatin Diabetes Study) showed that atorvastatin 10 mg/day (vs p...

journal_title：Drugs

authors： Arca M

更新日期：2007-01-01 00:00:00

abstract：:Fluticasone furoate nasal spray is a new topical intranasal corticosteroid with enhanced affinity for the glucocorticoid receptor and low systemic exposure, which was recently approved in the US for the treatment of seasonal or perennial allergic rhinitis in adults and in children aged >or=2 years. Fluticasone furoate...

journal_title：Drugs

authors： McCormack PL,Scott LJ

更新日期：2007-01-01 00:00:00

abstract：:Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene (HAO1; encodes glycolate oxidase) and was developed by Alnylam Pharmaceuticals for the treatment of primary hyperoxaluria type 1 (PH1). By silencing the gene encoding glycolate oxidase, ...

journal_title：Drugs

authors： Scott LJ,Keam SJ

更新日期：2021-01-06 00:00:00

abstract：:Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...

journal_title：Drugs

authors： Ryan J,Ancelin ML

更新日期：2012-09-10 00:00:00

abstract：:Meticillin-resistant Staphylococcus aureus (MRSA) is an important cause of infection, particularly in hospitalized patients and those with significant healthcare exposure. In recent years, epidemic community-associated MRSA (CA-MRSA) infections occurring in patients without healthcare risk factors have become more fre...

journal_title：Drugs

authors： Patel M

更新日期：2009-01-01 00:00:00