Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials.

Abstract:

:Drug resistance occurrence is a global healthcare concern responsible for the increased morbidity and mortality in hospitals, time of hospitalisation and huge financial loss. The failure of the most antibiotics to kill "superbugs" poses the urgent need to develop innovative strategies aimed at not only controlling bacterial infection but also the spread of resistance. The prevention of pathogen host invasion by inhibiting bacterial virulence and biofilm formation, and the utilisation of bactericidal agents with different mode of action than classic antibiotics are the two most promising new alternative strategies to overcome antibiotic resistance. Based on these novel approaches, researchers are developing different advanced materials (nanoparticles, hydrogels and surface coatings) with novel antimicrobial properties. In this review, we summarise the recent advances in terms of engineered materials to prevent bacteria-resistant infections according to the antimicrobial strategies underlying their design.

authors

Bassegoda A,Ivanova K,Ramon E,Tzanov T

doi

10.1007/s00253-018-8776-0

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

2075-2089

issue

5

eissn

0175-7598

issn

1432-0614

pii

10.1007/s00253-018-8776-0

journal_volume

102

pub_type

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