当前位置： SCI文献检索 > INVESTIGATIONAL NEW DRUGS期刊下所有文献 > First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors.

First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors.

Abstract：

:Background C-Met, which is frequently activated in multiple cancers, has been implicated in tumor formation, progression, metastasis, angiogenesis, and resistance to multiple therapies. MK-8033 is a small-molecule inhibitor of c-Met that binds preferentially to the activated conformation, and has demonstrated anti-tumor activity in preclinical models. This first-in-human trial was performed to establish the safety and maximum tolerated dose (MTD), as well as preliminary pharmacokinetics (PK) and clinical activity. Methods Forty-seven patients were enrolled in three parts. The primary objective of Parts A and B was safety, whereas Part C evaluated the effect of proton-pump inhibitors on MK-8033 absorption. Dose escalation used an accelerated continual reassessment method, and dose-limiting toxicities (DLTs) were any treatment-related, first course non-hematologic grade ≥ 3 toxicity (except alopecia or inadequately treated nausea/vomiting/diarrhea), grade 4 hematologic toxicity (except grade 3 neutropenic fever and thrombocytopenia), or toxicity where treatment is held >3 weeks. Results Forty-six patients were treated across nine dose levels, and the MTD was 750 mg twice daily. DLTs were fatigue, nausea, vomiting, transaminitis, and hypokalemia. Most frequent toxicities were fatigue (28.3%), nausea (21.7%), and alopecia (19.6%), predominately grade ≤ 2. One patient with endometriod adenocarcinoma achieved a partial response and eight had stable disease. Median progression-free survival (PFS) was 57 days. Strikingly, the PFS for the one responder was 846 days. PK results showed that proton-pump inhibitors have no effect on MK-8033 absorption. Conclusion MK-8033 was well tolerated with no significant toxicity issues, albeit with limited clinical activity. Unfortunately, the company decided to discontinue further clinical development of MK-8033.

journal_name

Invest New Drugs

journal_title

Investigational new drugs

authors

Keedy VL,Lenz HJ,Saltz L,Whisenant JG,Berlin JD,Camacho LH

doi

10.1007/s10637-018-0567-z

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

860-868

issue

eissn

0167-6997

issn

1573-0646

pii

10.1007/s10637-018-0567-z

journal_volume

pub_type

杂志文章,多中心研究

在线工具

First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors.