当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster.

Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster.

Abstract：

:Interaction of the orexinergic (ORXergic) neuronal system with the excitatory (glutamate, l-Glu) or the inhibitory (GABA) neurosignaling complexes evokes major homeostatic physiological events. In this study, effects of the two ORXergic neuropeptides (ORX-A/B) on their receptor (ORX-2R) expression changes were correlated to feeding and grooming actions of the hibernating hamster (Mesocricetus auratus). Infusion of the central amygdala nucleus (CeA) with ORX-A caused hamsters to consume notable quantities of food, while ORX-B accounted for a moderate increase. Interestingly the latter neuropeptide was responsible for greater frequencies of grooming with respect to both controls and the hamsters treated with ORX-A. These distinct behavioral changes turned out to be even greater in the presence of l-Glu agonist (NMDA) while the α1 GABAA receptor agonist (zolpidem, Zol) greatly reduced ORX-A-dependent feeding bouts. Moreover, ORX-A+NMDA mainly promoted greater ORX-2R expression levels with respect to ORX-A-treated hamsters while ORX-B+Zol was instead largely responsible for a down-regulatory trend. Overall, these features point to CeA ORX-2R sites as key sensory limbic elements capable of regulating eating and grooming responses, which may provide useful insights regarding the type of molecular mechanism(s) operating during feeding bouts.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Alò R,Avolio E,Mele M,Di Vito A,Canonaco M

doi

10.1016/j.jns.2015.02.030

subject

Has Abstract

pub_date

2015-04-15 00:00:00

pages

46-51

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(15)00097-0

journal_volume

351

pub_type

杂志文章

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