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Repeated mechanical lengthening of intestinal segments in a novel model.

Abstract：

PURPOSE:Currently, animal models used for mechanical intestinal lengthening utilize a single lengthening procedure prior to analysis or restoration back into continuity. Here we developed a novel surgical model to examine the feasibility of repeated lengthening of intestinal segments. METHODS:A Roux-en-Y jejunojejunostomy with a blind Roux limb was created in rats. An encapsulated polycaprolactone spring was placed into a 1cm segment of the Roux limb. After 4 weeks, a second encapsulated PCL spring was inserted into a 1cm portion of the lengthened segment. After another 4 weeks, the repeatedly lengthened segments were retrieved for histological analyses. RESULTS:Jejunal segments of the Roux limb were successfully lengthened from 1.0 cm to 2.6 ± 0.7 cm. Four weeks after the second PCL spring placement, 1.0 cm of the previously lengthened segment increased to 2.7 ± 0.8 cm. Stronger mechanical force was required to achieve subsequent re-lengthening. Lengthened and re-lengthened segments had increased smooth muscle thickness and crypt depth when compared to normal jejunal mucosa. CONCLUSION:Using the Roux-en-Y model, previously lengthened segments of intestine can be successfully re-lengthened. Intestinal segments may be subjected to multiple lengthening procedures to achieve clinically significant length for the treatment of short bowel syndrome.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Scott A,Sullins VF,Steinberger D,Rouch JD,Wagner JP,Chiang E,Lee SL,Wu BM,Dunn JC

doi

10.1016/j.jpedsurg.2015.03.020

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

954-7

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(15)00191-8

journal_volume

50

pub_type

杂志文章

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