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Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets.

Abstract：

BACKGROUND/PURPOSE:Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32 degrees C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PREM), 1 to 2 days (NB), and 1 to 2 weeks (NEO). METHODS:Radiolabeled microspheres were used to determine organ blood flows (mL/min/g) at baseline, 15, and 60 minutes after HT and 60 minutes after rewarming to baseline core temperature. RESULTS:Heart rate and cardiac output decreased significantly in all groups. Cardiac flow decreased significantly in the NEO group, and central nervous system (CNS) flow decreased significantly in the NB and NEO groups. Both returned to baseline levels after rewarming. The PREM group experienced decreased cardiac, CNS, and intestinal blood flows but not to significant levels. NB and NEO intestinal blood flow showed significant decreases, which remained so after rewarming (a response not seen in hypoxia or hypovolemia). Cardiac output did not return to baseline levels in any group. CONCLUSIONS:HT causes derangements in organ blood flows that differ from other deleterious stimuli such as hypoxia and hypovolemia. The prolonged intestinal ischemia supports HT as a factor in the development of NEC. This delay may offer opportunity to intervene in an attempt to lessen ischemia-reperfusion injury.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Powell RW,Dyess DL,Collins JN,Roberts WS,Tacchi EJ,Swafford AN Jr,Ferrara JJ,Ardell JL

doi

10.1016/s0022-3468(99)90255-5

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

193-8

issue

1

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(99)90255-5

journal_volume

34

pub_type

杂志文章

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