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Intestinal resection induces angiogenesis within adapting intestinal villi.

Abstract：

PURPOSE:Adaptive growth of the intestinal mucosa in response to massive gut loss is fundamental for autonomy from parenteral nutrition. Although angiogenesis is essential for cellular proliferation in other tissues, its relevance to intestinal adaptation is unknown. We tested the hypothesis that resection-induced adaptation is associated with new blood vessel growth. METHODS:Male C57Bl/6 mice underwent either a 50% small bowel resection or a sham (transection and reanastomosis) operation. After 1, 3, or 7 days, capillary density within the intestinal villi was measured using confocal microscopy. A messenger RNA reverse-transcriptase polymerase chain reaction (RT-PCR) array was used to determine angiogenic gene expression during adaptation. RESULTS:Mice that underwent small bowel resection had a significantly increased capillary density compared to sham-operated mice at postoperative day 7. This morphological alteration was preceded by significant alterations in 5 candidate genes at postoperative day 3. CONCLUSION:New vessel blood growth is observed in the adapting intestine after massive small bowel loss. This response appears to follow rather than initiate the adaptive alterations in mucosal morphology that are characteristic of adaptation. A better understanding of this progress and the signaling factors involved may improve therapeutic options for children with short gut syndrome.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Martin CA,Perrone EE,Longshore SW,Toste P,Bitter K,Nair R,Guo J,Erwin CR,Warner BW

doi

10.1016/j.jpedsurg.2009.02.036

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1077-82; discussion 1083

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(09)00163-8

journal_volume

44

pub_type

杂志文章

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