Antibiotic management of complicated appendicitis.

Abstract:

:A prospective, randomized, double-blind clinical trial was undertaken comparing gentamicin, ampicillin, and clindamycin (GAC) to gentamicin, ampicillin, and placebo (GAP) in children with complicated appendicitis. Of the 64 patients enrolled in this study, 33 were assigned to the GAC group and 31 received GAP. A single GAC patient (3%) was considered a therapeutic failure in comparison to seven children (23%) in the GAP group (P less than 0.05). Duration of fever was significantly prolonged in the GAP patients (4.7 +/- .8 days versus 2.9 +/- .5 days) when compared to the clindamycin treated children (P less than 0.05). Duration of leukocytosis was 3.2 +/- .4 days for GAC patients and 4.9 +/- .9 days for those on the GAP protocol (P = 0.08). On the basis of this experience the routine use of gentamicin, ampicillin, and clindamycin is recommended for all children with complicated appendicitis.

journal_name

J Pediatr Surg

authors

King DR,Browne AF,Birken GA,Hilty MD,Kerzner B,Boles ET Jr

doi

10.1016/s0022-3468(83)80051-7

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

945-50

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022346883001293

journal_volume

18

pub_type

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