Abstract:
:Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases caused by the misfolding of the cellular prion protein to an infectious form PrP(Sc). The intercellular transfer of PrP(Sc) is a question of immediate interest as the cell-to-cell movement of the infectious particle causes the inexorable propagation of disease. We have previously identified tunneling nanotubes (TNTs) as one mechanism by which PrP(Sc) can move between cells. Here we investigate further the details of this mechanism and show that PrP(Sc) travels within TNTs in endolysosomal vesicles. Additionally we show that prion infection of CAD cells increases both the number of TNTs and intercellular transfer of membranous vesicles, thereby possibly playing an active role in its own intercellular transfer via TNTs.
journal_name
Prionjournal_title
Prionauthors
Zhu S,Victoria GS,Marzo L,Ghosh R,Zurzolo Cdoi
10.1080/19336896.2015.1025189subject
Has Abstractpub_date
2015-01-01 00:00:00pages
125-35issue
2eissn
1933-6896issn
1933-690Xjournal_volume
9pub_type
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