Abstract:
:Prions are responsible for a heterogeneous group of fatal neurodegenerative diseases. They can be sporadic, genetic, or infectious disorders involving post-translational modifications of the cellular prion protein (PrP(C)). Prions (PrP(Sc)) are characterized by their infectious property and intrinsic ability to convert the physiological PrP(C) into the pathological form, acting as a template. The "protein-only" hypothesis, postulated by Stanley B. Prusiner, implies the possibility to generate de novo prions in vivo and in vitro. Here we describe major milestones towards proving this hypothesis, taking into account physiological environment/s, biochemical properties and interactors of the PrP(C).
journal_name
Prionjournal_title
Prionauthors
Benetti F,Legname Gdoi
10.4161/pri.3.4.10181subject
Has Abstractpub_date
2009-10-01 00:00:00pages
213-9issue
4eissn
1933-6896issn
1933-690Xpii
10181journal_volume
3pub_type
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