Abstract:
:Scrapie and CWD are horizontally transmissible, and the environment likely serves as a stable reservoir of infectious prions, facilitating a sustained incidence of CWD in free-ranging cervid populations and complicating efforts to eliminate disease in captive herds. Prions will enter the environment through mortalities and/or shedding from live hosts. Unfortunately, a sensitive detection method to identify prion contamination in environmental samples has not yet been developed. An environmentally-relevant prion model must be used in experimental studies. Changes in PrP(Sc) structure upon environmental exposure may be as significant as changes in PrP(Sc) quantity, since the structure can directly affect infectivity and disease pathology. Prions strongly bind to soil and remain infectious. Conformational changes upon adsorption, competitive sorption and potential for desorption and transport all warrant further investigation. Mitigation of contaminated carcasses or soil might be accomplished with enzyme treatments or composting in lieu of incineration.
journal_name
Prionjournal_title
Prionauthors
Saunders SE,Bartelt-Hunt SL,Bartz JCdoi
10.4161/pri.2.4.7951subject
Has Abstractpub_date
2008-10-01 00:00:00pages
162-9issue
4eissn
1933-6896issn
1933-690Xpii
7951journal_volume
2pub_type
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