Abstract:
:Growing evidence indicates that astrocytes cannot be just considered as passive supportive cells deputed to preserve neuronal activity and survival, but rather they are involved in a striking number of active functions that are critical to the performance of the central nervous system (CNS). As a consequence, it is becoming more and more evident that the peculiar properties of these cells can actively contribute to the extraordinary functional complexity of the brain and spinal cord. This new perception of the functioning of the CNS opens up a wide range of new possibilities to interpret various physiological and pathological events, and moves the focus beyond the neuronal compartment toward astrocyte-neuron interactions. With this in mind, here we provide a synopsis of the activities astrocytes perform in normal conditions, and we try to discuss what goes wrong with these cells in specific pathological conditions, such as Alzheimer Disease, prion diseases and amyotrophic lateral sclerosis.
journal_name
Prionjournal_title
Prionauthors
Brambilla L,Martorana F,Rossi Ddoi
10.4161/pri.22512subject
Has Abstractpub_date
2013-01-01 00:00:00pages
28-36issue
1eissn
1933-6896issn
1933-690Xpii
22512journal_volume
7pub_type
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