Abstract:
OBJECTIVES:To investigate if brain gamma-aminobutyric acid (GABA) levels in patients with relapsing-remitting multiple sclerosis (RRMS) are abnormal compared with healthy controls, and their relationship to cognitive function in RRMS. METHODS:Twenty-eight RRMS patients and twenty-six healthy controls underwent magnetic resonance spectroscopy (MRS) at 3-T to detect GABA signals from posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC) and left hippocampus using the 'MEGAPoint Resolved Spectroscopy Sequence' (MEGA-PRESS) technique. All subjects also underwent a cognitive assessment. RESULTS:In RRMS patients, GABA+ were lower in the PCC (p = 0.036) and left hippocampus (p = 0.039) compared with controls, decreased GABA+ in the PCC and left hippocampus were associated with specific cognitive functions (r = -0.452, p = 0.016 and r = 0.451, p = 0.016 respectively); GABA+ in the mPFC were not significantly decreased or related to any cognitive scores (p > 0.05). CONCLUSIONS:This study demonstrates that abnormalities of the GABAergic system may be present in the pathogenesis of RRMS and suggests a potential link between regional GABA levels and cognitive impairment in patients with RRMS. KEY POINTS:• GABA levels may decrease in patients with RRMS. • Lower GABA levels correlated with worse cognitive performance in patients with RRMS. • Dysfunctional GABAergic neurotransmission may have a role in cognitive impairment in RRMS.
journal_name
Eur Radioljournal_title
European radiologyauthors
Cao G,Edden RAE,Gao F,Li H,Gong T,Chen W,Liu X,Wang G,Zhao Bdoi
10.1007/s00330-017-5064-9subject
Has Abstractpub_date
2018-03-01 00:00:00pages
1140-1148issue
3eissn
0938-7994issn
1432-1084pii
10.1007/s00330-017-5064-9journal_volume
28pub_type
杂志文章abstract:OBJECTIVES:The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. METHODS:PMCTs were compared with autop...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2779-0
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS:Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5049-8
更新日期:2018-03-01 00:00:00
abstract::Sacral insufficiency fractures develop over a period of time and show time-dependent changes. We report on 15 CT examinations of 5 patients with early-stage insufficiency fractures of the sacrum. In 4 patients only irregular sclerosis without distinct fracture lines was present in 7 of 8 fractures. Of these 4 patients...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/BF00187667
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:We aimed to estimate the prevalence of combined pulmonary fibrosis and emphysema (CPFE) and describe the follow-up CT results of CPFE in asymptomatic smokers. METHODS:This study was retrospective, and approved by an institutional review board. CT images of 2,016 current or previous male smokers who underwen...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3617-3
更新日期:2015-08-01 00:00:00
abstract::We report a case of alveolar soft part sarcoma (ASPS) of the thigh with lung metastases in a 22-year-old woman. The findings of digital subtraction angiography (DSA) and MRI contributed to the diagnosis of ASPS. Especially dynamic contrast-enhanced MRI was useful for evaluating the effect of chemoembolotherapy. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050477
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the methodological quality of diagnostic accuracy studies on coronary computed tomography (CT) angiography using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) tool. METHODS:Each QUADAS item was individually defined to adapt it to the special requir...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2763-0
更新日期:2013-06-01 00:00:00
abstract::Hepatobiliary contrast agents with uptake into hepatocytes followed by variable biliary excretion represent a unique class of cell-specific MR contrast agents. Two hepatobiliary contrast agents, mangafodipir trisodium and gadobenate dimeglumine, are already clinically approved. A third hepatobiliary contrast agent, Gd...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-004-2236-1
更新日期:2004-04-01 00:00:00
abstract::Facial injuries are common and require radiologic evaluation to plan treatment. The role of imaging is to detect fractures, describe their morphology and topography, and evaluate adjacent soft tissue damage. Computed tomography is the imaging method of choice for an accurate diagnosis and for depicting the complex ana...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1445-8
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:To identify dynamic contrast-enhanced (DCE) imaging parameters from MRI, CT and US that are prognostic and predictive in patients with metastatic renal cell cancer (mRCC) receiving sunitinib. METHODS:Thirty-four patients were monitored by DCE imaging on day 0 and 14 of the first course of sunitinib treatmen...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5220-2
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:To assess whether with recent MR technology current patient preparation literature recommendations for female pelvic MRI are still valid and how they are influencing the position of the female pelvic organs, image quality, and diagnostic confidence. METHODS:This prospective study was performed in two centre...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06869-8
更新日期:2020-10-01 00:00:00
abstract::Because of its sensitivity and high tissue contrast, magnetic resonance imaging (MRI) is the technique of choice for structural imaging in epilepsy. In this review the effect of using optimised scanning protocols and the use of high field MR systems on detection sensitivity is discussed. Also, the clinical relevance o...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-007-0710-2
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To compare image quality and radiation dose using Adaptive Statistical Iterative Reconstruction (ASiR) and Filtered Back Projection (FBP) in patients weighing ≥ 91 kg. METHODS:In this Institution Review Board-approved retrospective study, single-phase contrast-enhanced abdominopelvic CT examinations of 100 a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2424-3
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:To investigate pulmonary vasculature opacification during CTPA using an optimised patient-specific protocol for administering contrast agent. METHODS:CTPA was performed on 200 patients with suspected PE. Patients were assigned to two protocol groups: protocol A, fixed 80 ml contrast agent; protocol B used a...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2919-6
更新日期:2013-11-01 00:00:00
abstract:AIMS AND OBJECTIVES:Deep venous thrombosis (DVT) can be difficult to detect using CT due to poor and heterogeneous contrast. Dual-energy CT (DECT) allows iodine contrast optimization using noise-optimized monoenergetic extrapolations (MEIs) and iodine maps (IMs). Our aim was to assess whether MEI and IM could improve t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3544-8
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To develop an MRI enterography global score (MEGS) of Crohn's disease (CD) activity compared with a reference standard of faecal calprotectin (fC), C-reactive protein (CRP) and Harvey-Bradshaw index (HBI). METHODS:Calprotectin, CRP and HBI were prospectively recorded for 71 patients (median age 33, male 35)...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-3010-z
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To evaluate an image-navigated isotropic high-resolution 3D late gadolinium enhancement (LGE) prototype sequence with compressed sensing and Dixon water-fat separation in a clinical routine setting. MATERIAL AND METHODS:Forty consecutive patients scheduled for cardiac MRI were enrolled prospectively and exa...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07517-x
更新日期:2020-12-02 00:00:00
abstract:OBJECTIVES:To validate a visual rating scale of frontal atrophy with quantitative imaging and study its association with clinical status, APOE ε4, CSF biomarkers, and cognition. METHODS:The AddNeuroMed and ADNI cohorts were combined giving a total of 329 healthy controls, 421 mild cognitive impairment patients, and 28...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4101-9
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:To investigate the association of chest CT findings with mortality in clinical management of older patients. METHODS:From January 21 to February 14, 2020, 98 older patients (≥ 60 years) who had undergone chest CT scans ("initial CT") on admission were enrolled. Manifestation and CT score were compared betwe...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06969-5
更新日期:2020-11-01 00:00:00
abstract::The appearances of knee injuries on MR imaging are less well documented in children than adults. Some patterns of injury are shared by both groups of patients, e. g. meniscal damage. The frequency of specific injuries may differ, e. g. anterior cruciate ligament (ACL) tear. Congenital abnormality, coexistent pathology...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050284
更新日期:1997-01-01 00:00:00
abstract::The imaging findings that ultrasonographically differentiate focal acute pancreatitis (FAP) from a malignant lesion of the pancreas are described. Focal acute pancreatitis is ultrasonographically (US) characterized as a hypoechoic, homogeneous, localized, subsegmental, non-expansive and diffusely demarcated lesion loc...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050756
更新日期:1999-01-01 00:00:00
abstract::To quantify permeability changes of the "blood-bone marrow barrier" (BMB) and to detect malignant bone marrow infiltrations before and after conditioning therapy for subsequent leukapheresis using ferumoxtran-10-enhanced magnetic resonance (MR) imaging. Twenty-two patients with malignant non-Hodgkin lymphomas (NHL), i...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-0045-9
更新日期:2006-03-01 00:00:00
abstract::Cross-sectional imaging has revolutionised the radiological diagnosis of pleural collections. Not only can the precise location and volume of a pleural effusion be established, but also features specific for the aetiology of the effusion can be demonstrated. Increasingly, radiologists are called upon to perform image-...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1512-1
更新日期:2002-08-01 00:00:00
abstract::Many disease processes manifest either primarily or secondarily by cranial nerve deficits. Neurologists, ENT surgeons, ophthalmologists and maxillo-facial surgeons are often confronted with patients with symptoms and signs of cranial nerve dysfunction. Seeking the cause of this dysfunction is a common indication for i...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-006-0575-9
更新日期:2007-08-01 00:00:00
abstract::The purpose of our animal study was to evaluate a new computed tomography (CT) subtraction technique for visualization of perfusion defects within the lung parenchyma in subsegmental pulmonary embolism (PE). Seven healthy pigs were entered into a prospective trial. Acute PE was artificially induced by fresh clot mater...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2718-9
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:Various imaging methods have been evaluated regarding non-invasive differentiation of renal cell carcinoma (RCC) subtypes. Dual-energy computed tomography (DECT) allows iodine concentration (IC) analysis as a correlate of tissue perfusion. Microvascular density (MVD) in histopathology specimens is evaluated ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06298-2
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To determine variability of volume computed tomographic dose index (CTDIvol) and dose-length product (DLP) data, and propose a minimum sample size to achieve an expected precision. METHODS:CTDIvol and DLP values of 19,875 consecutive CT acquisitions of abdomen (7268), thorax (3805), lumbar spine (3161), cer...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-016-4333-3
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To investigate the optimal imaging delay time of dynamic contrast-enhanced magnetic resonance (MR) imaging in women with endometrial cancer. MATERIALS AND METHODS:This prospective single-institution study was approved by the institutional review board, and informed consent was obtained from the participants. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3327-2
更新日期:2014-11-01 00:00:00
abstract::There is yet no consensus on the application of functional imaging and qualitative image interpretation in the management of gastric cancer. In this second part, we will discuss the role of image-derived quantitative parameters from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 18F-fluorodeoxygluc...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-019-06370-x
更新日期:2020-01-01 00:00:00
abstract::We evaluated the US findings in acute idiopathic scrotal edema (AISE) in order to identify diagnostic features that may help to avoid unnecessary surgical intervention. We investigated 12 boys with AISE diagnosed according to the clinical course and US findings. We assessed the thickness, compressibility, and vascular...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1356-z
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:Comparison of bolus tracking with a fixed threshold versus a manual fast start for coronary CT angiography. METHODS:We retrospectively analysed 320-row coronary CT angiography of 50 patients with suspected or known coronary artery disease. Twenty-five examinations were initiated by a bolus tracking method (...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3148-3
更新日期:2014-06-01 00:00:00