Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis.

Abstract:

OBJECTIVES:To investigate if brain gamma-aminobutyric acid (GABA) levels in patients with relapsing-remitting multiple sclerosis (RRMS) are abnormal compared with healthy controls, and their relationship to cognitive function in RRMS. METHODS:Twenty-eight RRMS patients and twenty-six healthy controls underwent magnetic resonance spectroscopy (MRS) at 3-T to detect GABA signals from posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC) and left hippocampus using the 'MEGAPoint Resolved Spectroscopy Sequence' (MEGA-PRESS) technique. All subjects also underwent a cognitive assessment. RESULTS:In RRMS patients, GABA+ were lower in the PCC (p = 0.036) and left hippocampus (p = 0.039) compared with controls, decreased GABA+ in the PCC and left hippocampus were associated with specific cognitive functions (r = -0.452, p = 0.016 and r = 0.451, p = 0.016 respectively); GABA+ in the mPFC were not significantly decreased or related to any cognitive scores (p > 0.05). CONCLUSIONS:This study demonstrates that abnormalities of the GABAergic system may be present in the pathogenesis of RRMS and suggests a potential link between regional GABA levels and cognitive impairment in patients with RRMS. KEY POINTS:• GABA levels may decrease in patients with RRMS. • Lower GABA levels correlated with worse cognitive performance in patients with RRMS. • Dysfunctional GABAergic neurotransmission may have a role in cognitive impairment in RRMS.

journal_name

Eur Radiol

journal_title

European radiology

authors

Cao G,Edden RAE,Gao F,Li H,Gong T,Chen W,Liu X,Wang G,Zhao B

doi

10.1007/s00330-017-5064-9

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

1140-1148

issue

3

eissn

0938-7994

issn

1432-1084

pii

10.1007/s00330-017-5064-9

journal_volume

28

pub_type

杂志文章
  • Post-mortem computed tomography compared to forensic autopsy findings: a French experience.

    abstract:OBJECTIVES:The principal aim of our study was to establish concordance between post-mortem CT (PMCT) and forensic standard autopsy (SA) in detecting lesions according to different anatomical regions. A secondary aim was to determine the efficacy of PMCT in showing lethal lesions. METHODS:PMCTs were compared with autop...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-013-2779-0

    authors: Le Blanc-Louvry I,Thureau S,Duval C,Papin-Lefebvre F,Thiebot J,Dacher JN,Gricourt C,Touré E,Proust B

    更新日期:2013-07-01 00:00:00

  • Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with an IVIM Model.

    abstract:OBJECTIVES:To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS:Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-5049-8

    authors: Qi LP,Yan WP,Chen KN,Zhong Z,Li XT,Cai K,Sun YS,Zhou XJ

    更新日期:2018-03-01 00:00:00

  • Time-dependent changes of insufficiency fractures of the sacrum: intraosseous vacuum phenomenon as an early sign.

    abstract::Sacral insufficiency fractures develop over a period of time and show time-dependent changes. We report on 15 CT examinations of 5 patients with early-stage insufficiency fractures of the sacrum. In 4 patients only irregular sclerosis without distinct fracture lines was present in 7 of 8 fractures. Of these 4 patients...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/BF00187667

    authors: Stäbler A,Steiner W,Kohz P,Bartl R,Berger H,Reiser M

    更新日期:1996-01-01 00:00:00

  • Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: A case-control study.

    abstract:OBJECTIVES:We aimed to estimate the prevalence of combined pulmonary fibrosis and emphysema (CPFE) and describe the follow-up CT results of CPFE in asymptomatic smokers. METHODS:This study was retrospective, and approved by an institutional review board. CT images of 2,016 current or previous male smokers who underwen...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-015-3617-3

    authors: Chae KJ,Jin GY,Han YM,Kim YS,Chon SB,Lee YS,Kwon KS,Choi HM,Lynch D

    更新日期:2015-08-01 00:00:00

  • Alveolar soft part sarcoma.

    abstract::We report a case of alveolar soft part sarcoma (ASPS) of the thigh with lung metastases in a 22-year-old woman. The findings of digital subtraction angiography (DSA) and MRI contributed to the diagnosis of ASPS. Especially dynamic contrast-enhanced MRI was useful for evaluating the effect of chemoembolotherapy. ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050477

    authors: Nakanishi K,Araki N,Yoshikawa H,Hashimoto T,Nakamura H

    更新日期:1998-01-01 00:00:00

  • Methodological quality of diagnostic accuracy studies on non-invasive coronary CT angiography: influence of QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) items on sensitivity and specificity.

    abstract:OBJECTIVES:To evaluate the methodological quality of diagnostic accuracy studies on coronary computed tomography (CT) angiography using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) tool. METHODS:Each QUADAS item was individually defined to adapt it to the special requir...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-012-2763-0

    authors: Schueler S,Walther S,Schuetz GM,Schlattmann P,Dewey M

    更新日期:2013-06-01 00:00:00

  • Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications.

    abstract::Hepatobiliary contrast agents with uptake into hepatocytes followed by variable biliary excretion represent a unique class of cell-specific MR contrast agents. Two hepatobiliary contrast agents, mangafodipir trisodium and gadobenate dimeglumine, are already clinically approved. A third hepatobiliary contrast agent, Gd...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-004-2236-1

    authors: Reimer P,Schneider G,Schima W

    更新日期:2004-04-01 00:00:00

  • Traumatic injuries: imaging of facial injuries.

    abstract::Facial injuries are common and require radiologic evaluation to plan treatment. The role of imaging is to detect fractures, describe their morphology and topography, and evaluate adjacent soft tissue damage. Computed tomography is the imaging method of choice for an accurate diagnosis and for depicting the complex ana...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-002-1445-8

    authors: Salvolini U

    更新日期:2002-06-01 00:00:00

  • The prognostic and predictive value of vascular response parameters measured by dynamic contrast-enhanced-CT, -MRI and -US in patients with metastatic renal cell carcinoma receiving sunitinib.

    abstract:OBJECTIVES:To identify dynamic contrast-enhanced (DCE) imaging parameters from MRI, CT and US that are prognostic and predictive in patients with metastatic renal cell cancer (mRCC) receiving sunitinib. METHODS:Thirty-four patients were monitored by DCE imaging on day 0 and 14 of the first course of sunitinib treatmen...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-5220-2

    authors: Hudson JM,Bailey C,Atri M,Stanisz G,Milot L,Williams R,Kiss A,Burns PN,Bjarnason GA

    更新日期:2018-06-01 00:00:00

  • Patient preparation and image quality in female pelvic MRI: recommendations revisited.

    abstract:OBJECTIVES:To assess whether with recent MR technology current patient preparation literature recommendations for female pelvic MRI are still valid and how they are influencing the position of the female pelvic organs, image quality, and diagnostic confidence. METHODS:This prospective study was performed in two centre...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-06869-8

    authors: Sheikh-Sarraf M,Nougaret S,Forstner R,Kubik-Huch RA

    更新日期:2020-10-01 00:00:00

  • Structural magnetic resonance imaging in epilepsy.

    abstract::Because of its sensitivity and high tissue contrast, magnetic resonance imaging (MRI) is the technique of choice for structural imaging in epilepsy. In this review the effect of using optimised scanning protocols and the use of high field MR systems on detection sensitivity is discussed. Also, the clinical relevance o...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-007-0710-2

    authors: Deblaere K,Achten E

    更新日期:2008-01-01 00:00:00

  • Impact of iterative reconstruction on image quality and radiation dose in multidetector CT of large body size adults.

    abstract:OBJECTIVE:To compare image quality and radiation dose using Adaptive Statistical Iterative Reconstruction (ASiR) and Filtered Back Projection (FBP) in patients weighing ≥ 91 kg. METHODS:In this Institution Review Board-approved retrospective study, single-phase contrast-enhanced abdominopelvic CT examinations of 100 a...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-012-2424-3

    authors: Desai GS,Uppot RN,Yu EW,Kambadakone AR,Sahani DV

    更新日期:2012-08-01 00:00:00

  • An optimised patient-specific approach to administration of contrast agent for CT pulmonary angiography.

    abstract:OBJECTIVES:To investigate pulmonary vasculature opacification during CTPA using an optimised patient-specific protocol for administering contrast agent. METHODS:CTPA was performed on 200 patients with suspected PE. Patients were assigned to two protocol groups: protocol A, fixed 80 ml contrast agent; protocol B used a...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-013-2919-6

    authors: Saade C,Bourne R,El-Merhi F,Somanathan A,Chakraborty D,Brennan P

    更新日期:2013-11-01 00:00:00

  • Noise-optimized virtual monoenergetic images and iodine maps for the detection of venous thrombosis in second-generation dual-energy CT (DECT): an ex vivo phantom study.

    abstract:AIMS AND OBJECTIVES:Deep venous thrombosis (DVT) can be difficult to detect using CT due to poor and heterogeneous contrast. Dual-energy CT (DECT) allows iodine contrast optimization using noise-optimized monoenergetic extrapolations (MEIs) and iodine maps (IMs). Our aim was to assess whether MEI and IM could improve t...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-014-3544-8

    authors: Bongers MN,Schabel C,Krauss B,Tsiflikas I,Ketelsen D,Mangold S,Claussen CD,Nikolaou K,Thomas C

    更新日期:2015-06-01 00:00:00

  • Evaluation of Crohn's disease activity: initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin.

    abstract:OBJECTIVES:To develop an MRI enterography global score (MEGS) of Crohn's disease (CD) activity compared with a reference standard of faecal calprotectin (fC), C-reactive protein (CRP) and Harvey-Bradshaw index (HBI). METHODS:Calprotectin, CRP and HBI were prospectively recorded for 71 patients (median age 33, male 35)...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-013-3010-z

    authors: Makanyanga JC,Pendsé D,Dikaios N,Bloom S,McCartney S,Helbren E,Atkins E,Cuthbertson T,Punwani S,Forbes A,Halligan S,Taylor SA

    更新日期:2014-02-01 00:00:00

  • 3D Dixon water-fat LGE imaging with image navigator and compressed sensing in cardiac MRI.

    abstract:OBJECTIVES:To evaluate an image-navigated isotropic high-resolution 3D late gadolinium enhancement (LGE) prototype sequence with compressed sensing and Dixon water-fat separation in a clinical routine setting. MATERIAL AND METHODS:Forty consecutive patients scheduled for cardiac MRI were enrolled prospectively and exa...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-07517-x

    authors: Zeilinger MG,Wiesmüller M,Forman C,Schmidt M,Munoz C,Piccini D,Kunze KP,Neji R,Botnar RM,Prieto C,Uder M,May M,Wuest W

    更新日期:2020-12-02 00:00:00

  • Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition.

    abstract:OBJECTIVES:To validate a visual rating scale of frontal atrophy with quantitative imaging and study its association with clinical status, APOE ε4, CSF biomarkers, and cognition. METHODS:The AddNeuroMed and ADNI cohorts were combined giving a total of 329 healthy controls, 421 mild cognitive impairment patients, and 28...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-015-4101-9

    authors: Ferreira D,Cavallin L,Granberg T,Lindberg O,Aguilar C,Mecocci P,Vellas B,Tsolaki M,Kłoszewska I,Soininen H,Lovestone S,Simmons A,Wahlund LO,Westman E,AddNeuroMed consortium and for the Alzheimer’s Disease Neuroimaging Initiat

    更新日期:2016-08-01 00:00:00

  • Association of "initial CT" findings with mortality in older patients with coronavirus disease 2019 (COVID-19).

    abstract:OBJECTIVES:To investigate the association of chest CT findings with mortality in clinical management of older patients. METHODS:From January 21 to February 14, 2020, 98 older patients (≥ 60 years) who had undergone chest CT scans ("initial CT") on admission were enrolled. Manifestation and CT score were compared betwe...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-06969-5

    authors: Li Y,Yang Z,Ai T,Wu S,Xia L

    更新日期:2020-11-01 00:00:00

  • Magnetic resonance imaging of knee injuries in children.

    abstract::The appearances of knee injuries on MR imaging are less well documented in children than adults. Some patterns of injury are shared by both groups of patients, e. g. meniscal damage. The frequency of specific injuries may differ, e. g. anterior cruciate ligament (ACL) tear. Congenital abnormality, coexistent pathology...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300050284

    authors: King SJ

    更新日期:1997-01-01 00:00:00

  • New sonographic imaging observations in focal pancreatitis.

    abstract::The imaging findings that ultrasonographically differentiate focal acute pancreatitis (FAP) from a malignant lesion of the pancreas are described. Focal acute pancreatitis is ultrasonographically (US) characterized as a hypoechoic, homogeneous, localized, subsegmental, non-expansive and diffusely demarcated lesion loc...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050756

    authors: Lorén I,Lasson A,Fork T,Genell S,Nilsson A,Nilsson P,Nirhov N

    更新日期:1999-01-01 00:00:00

  • Ferumoxtran-10-enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with non-Hodgkin lymphomas.

    abstract::To quantify permeability changes of the "blood-bone marrow barrier" (BMB) and to detect malignant bone marrow infiltrations before and after conditioning therapy for subsequent leukapheresis using ferumoxtran-10-enhanced magnetic resonance (MR) imaging. Twenty-two patients with malignant non-Hodgkin lymphomas (NHL), i...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-005-0045-9

    authors: Metz S,Lohr S,Settles M,Beer A,Woertler K,Rummeny EJ,Daldrup-Link HE

    更新日期:2006-03-01 00:00:00

  • Non-traumatic thoracic emergencies: imaging and treatment of thoracic fluid collections (including pneumothorax).

    abstract::Cross-sectional imaging has revolutionised the radiological diagnosis of pleural collections. Not only can the precise location and volume of a pleural effusion be established, but also features specific for the aetiology of the effusion can be demonstrated. Increasingly, radiologists are called upon to perform image-...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-002-1512-1

    authors: Ellis JR,Gleeson FV

    更新日期:2002-08-01 00:00:00

  • Imaging the cranial nerves: Part I: methodology, infectious and inflammatory, traumatic and congenital lesions.

    abstract::Many disease processes manifest either primarily or secondarily by cranial nerve deficits. Neurologists, ENT surgeons, ophthalmologists and maxillo-facial surgeons are often confronted with patients with symptoms and signs of cranial nerve dysfunction. Seeking the cause of this dysfunction is a common indication for i...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-006-0575-9

    authors: Borges A,Casselman J

    更新日期:2007-08-01 00:00:00

  • Multislice computed tomography perfusion imaging for visualization of acute pulmonary embolism: animal experience.

    abstract::The purpose of our animal study was to evaluate a new computed tomography (CT) subtraction technique for visualization of perfusion defects within the lung parenchyma in subsegmental pulmonary embolism (PE). Seven healthy pigs were entered into a prospective trial. Acute PE was artificially induced by fresh clot mater...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-005-2718-9

    authors: Wildberger JE,Klotz E,Ditt H,Spüntrup E,Mahnken AH,Günther RW

    更新日期:2005-07-01 00:00:00

  • Papillary vs clear cell renal cell carcinoma. Differentiation and grading by iodine concentration using DECT-correlation with microvascular density.

    abstract:OBJECTIVES:Various imaging methods have been evaluated regarding non-invasive differentiation of renal cell carcinoma (RCC) subtypes. Dual-energy computed tomography (DECT) allows iodine concentration (IC) analysis as a correlate of tissue perfusion. Microvascular density (MVD) in histopathology specimens is evaluated ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-019-06298-2

    authors: Marcon J,Graser A,Horst D,Casuscelli J,Spek A,Stief CG,Reiser MF,Rübenthaler J,Buchner A,Staehler M

    更新日期:2020-01-01 00:00:00

  • CT dose survey in adults: what sample size for what precision?

    abstract:OBJECTIVES:To determine variability of volume computed tomographic dose index (CTDIvol) and dose-length product (DLP) data, and propose a minimum sample size to achieve an expected precision. METHODS:CTDIvol and DLP values of 19,875 consecutive CT acquisitions of abdomen (7268), thorax (3805), lumbar spine (3161), cer...

    journal_title:European radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00330-016-4333-3

    authors: Taylor S,Van Muylem A,Howarth N,Gevenois PA,Tack D

    更新日期:2017-01-01 00:00:00

  • Dynamic contrast-enhanced MR imaging of endometrial cancer: optimizing the imaging delay for tumour-myometrium contrast.

    abstract:PURPOSE:To investigate the optimal imaging delay time of dynamic contrast-enhanced magnetic resonance (MR) imaging in women with endometrial cancer. MATERIALS AND METHODS:This prospective single-institution study was approved by the institutional review board, and informed consent was obtained from the participants. T...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-014-3327-2

    authors: Park SB,Moon MH,Sung CK,Oh S,Lee YH

    更新日期:2014-11-01 00:00:00

  • Gastric cancer and image-derived quantitative parameters: Part 2-a critical review of DCE-MRI and 18F-FDG PET/CT findings.

    abstract::There is yet no consensus on the application of functional imaging and qualitative image interpretation in the management of gastric cancer. In this second part, we will discuss the role of image-derived quantitative parameters from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 18F-fluorodeoxygluc...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-019-06370-x

    authors: Tang L,Wang XJ,Baba H,Giganti F

    更新日期:2020-01-01 00:00:00

  • Acute idiopathic scrotal edema: ultrasonographic findings at an emergency unit.

    abstract::We evaluated the US findings in acute idiopathic scrotal edema (AISE) in order to identify diagnostic features that may help to avoid unnecessary surgical intervention. We investigated 12 boys with AISE diagnosed according to the clinical course and US findings. We assessed the thickness, compressibility, and vascular...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-009-1356-z

    authors: Lee A,Park SJ,Lee HK,Hong HS,Lee BH,Kim DH

    更新日期:2009-08-01 00:00:00

  • Contrast agent bolus tracking with a fixed threshold or a manual fast start for coronary CT angiography.

    abstract:OBJECTIVES:Comparison of bolus tracking with a fixed threshold versus a manual fast start for coronary CT angiography. METHODS:We retrospectively analysed 320-row coronary CT angiography of 50 patients with suspected or known coronary artery disease. Twenty-five examinations were initiated by a bolus tracking method (...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-014-3148-3

    authors: Stenzel F,Rief M,Zimmermann E,Greupner J,Richter F,Dewey M

    更新日期:2014-06-01 00:00:00