Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle.

abstract：:Urinary tract infection is primarily caused by Escherichia coli. Multidrug resistance and their rapid dissemination in this pathogenic microbe complicate therapeutic strategies and threaten public health. Conjugation systems responsible for interbacterial transmission of antibiotic resistance are plasmid-encoded and c...

journal_title：Frontiers in microbiology

authors： Mukherjee SK,Mukherjee M

更新日期：2019-12-18 00:00:00

abstract：:Over the past decades, antimicrobial resistance (AMR) has been recognized as one of the most serious threats to public health. Although originally considered a problem to human health, the emerging crisis of AMR requires a "One Health" approach, considering human, animal, and environmental reservoirs. In this regard, ...

journal_title：Frontiers in microbiology

authors： Rubiola S,Chiesa F,Dalmasso A,Di Ciccio P,Civera T

更新日期：2020-08-26 00:00:00

abstract：:Bacillus cereus is a gram-positive pathogen mainly known to evoke two types of foodborne poisonings. The diarrheal syndrome is caused by enterotoxins produced during growth in the intestine. In contrast, the emetic type is caused by the dodecadepsipeptide cereulide pre-formed in food. Usually, both diseases are self-l...

journal_title：Frontiers in microbiology

authors： Bauer T,Sipos W,Stark TD,Käser T,Knecht C,Brunthaler R,Saalmüller A,Hofmann T,Ehling-Schulz M

更新日期：2018-11-07 00:00:00

abstract：:Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of tar...

journal_title：Frontiers in microbiology

authors： Zhan L,Tang J,Sun M,Qin C

更新日期：2017-05-04 00:00:00

abstract：:We present a fluorometric method for determining ABC transporter activity in the pathogenic fungus C. albicans during different growth phases and in response to glucose. The carbocyanine dye diS-C3(3) was previously used to monitor plasma membrane potentials and test the influence of surface-active compounds in membra...

journal_title：Frontiers in microbiology

authors： Szczepaniak J,Łukaszewicz M,Krasowska A

更新日期：2015-12-09 00:00:00

abstract：:Recent microbiomic research of agricultural habitats has highlighted tremendous microbial biodiversity associated with such ecosystems. Data generated in vineyards have furthermore highlighted significant regional differences in vineyard biodiversity, hinting at the possibility that such differences might be responsib...

journal_title：Frontiers in microbiology

authors： Setati ME,Jacobson D,Bauer FF

更新日期：2015-11-30 00:00:00

abstract：:Oropharyngeal candidiasis is a common opportunistic mucosal infection of the oral cavity, mainly caused by an overgrowth of Candida albicans. This infection can inhibit nutritional intakes and strongly affect quality of life. To date, standard therapeutic strategies involving the administration of antifungal drugs can...

journal_title：Frontiers in microbiology

authors： Roselletti E,Sabbatini S,Ballet N,Perito S,Pericolini E,Blasi E,Mosci P,Cayzeele Decherf A,Monari C,Vecchiarelli A

更新日期：2019-07-11 00:00:00

abstract：:Bovine babesiosis is a tick-transmitted disease caused by different species of Babesia. The white yak is a unique yak breed that lives only in Tianzhu in the Tibetan Autonomous County, Gansu Province, in northwestern China. Previous research using the ELISA method has confirmed that the white yak could become infected...

journal_title：Frontiers in microbiology

authors： Liu J,Guan G,Li Y,Liu A,Luo J,Yin H

更新日期：2017-03-14 00:00:00

abstract：:Granulocytes mediate the first line of defense against infectious diseases in humans as well as animals and they are well known as multitasking cells. They can mediate antimicrobial activity by different strategies depending on the pathogen they encounter. Besides phagocytosis, a key strategy against extracellular pat...

journal_title：Frontiers in microbiology

authors： de Buhr N,Bonilla MC,Jimenez-Soto M,von Köckritz-Blickwede M,Dolz G

更新日期：2018-05-15 00:00:00

abstract：:We investigated the antifungal activity of novel a 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone (compound 4). The synthesis of compound 4 was commenced from sodium 4-chlorobenzene sulfinate and the final product was obtained by treatment of α-chloro-β-keto-sulfone with sodium hypobromite. The sensitivi...

journal_title：Frontiers in microbiology

authors： Staniszewska M,Bondaryk M,Wieczorek M,Estrada-Mata E,Mora-Montes HM,Ochal Z

更新日期：2016-08-25 00:00:00

abstract：:Pathogenic bacterial persisters are responsible for the recalcitrance of chronic and persistent infections to antimicrobial therapy. Although the mechanisms of persister formation and survival have been widely studied in Escherichia coli, persistence mechanisms in Staphylococcus aureus remain largely unknown. Here, we...

journal_title：Frontiers in microbiology

authors： Wang W,Chen J,Chen G,Du X,Cui P,Wu J,Zhao J,Wu N,Zhang W,Li M,Zhang Y

更新日期：2015-12-23 00:00:00

abstract：:Innovations in next-generation sequencing technology have introduced new avenues in microbial studies through "omics" approaches. This technology has considerably augmented the knowledge of the microbial world without isolation prior to their identification. With an enormous volume of bacterial "omics" data, considera...

journal_title：Frontiers in microbiology

authors： Parmar KM,Gaikwad SL,Dhakephalkar PK,Kothari R,Singh RP

更新日期：2017-04-07 00:00:00

abstract：:Deep subsurface aquifers despite difficult access, represent important water resources and, at the same time, are key locations for subsurface engineering activities for the oil and gas industries, geothermal energy, and CO2 or energy storage. Formation water originating from a 760 m-deep geological gas storage aquife...

journal_title：Frontiers in microbiology

authors： Aüllo T,Berlendis S,Lascourrèges JF,Dessort D,Duclerc D,Saint-Laurent S,Schraauwers B,Mas J,Patriarche D,Boesinger C,Magot M,Ranchou-Peyruse A

更新日期：2016-02-09 00:00:00

abstract：:In our previous study we demonstrated that proteinase PrtP is able to impair bacteriocin LcnB activity, despite being produced by the same organism and encoded by the same plasmid. However, precise mechanism of this action, i.e., the exact cleavage site within LcnB bacteriocin, as well as its effect on antimicrobial a...

journal_title：Frontiers in microbiology

authors： Vukotic G,Polovic N,Mirkovic N,Jovcic B,Stanisavljevic N,Fira D,Kojic M

更新日期：2019-04-24 00:00:00

abstract：:Infectious agents are common companions of humans and since ancient times they follow human migration on their search for a better place to live. The study of paleomicrobiology was significantly improved in its accuracy of measurement with the constant development of better methods to detect and analyze nucleic acids....

journal_title：Frontiers in microbiology

authors： Ishak R,Machado LFA,Cayres-Vallinoto I,Guimarães Ishak MO,Vallinoto ACR

更新日期：2017-08-31 00:00:00

abstract：:Increased river loads are projected as one of the major consequences of climate change in the northern hemisphere, leading to elevated inputs of riverine dissolved organic matter (DOM) and inorganic nutrients to coastal ecosystems. The objective of this study was to investigate the effects of elevated DOM on a coastal...

journal_title：Frontiers in microbiology

authors： Traving SJ,Rowe O,Jakobsen NM,Sørensen H,Dinasquet J,Stedmon CA,Andersson A,Riemann L

更新日期：2017-03-09 00:00:00

abstract：:Sequencing and annotation was performed for two large double stranded DNA bacteriophages, φGrn1 and φSt2 of the Myoviridae family, considered to be of great interest for phage therapy against Vibrios in aquaculture live feeds. In addition, phage-host metabolic interactions and exploitation was studied by transcript pr...

journal_title：Frontiers in microbiology

authors： Skliros D,Kalatzis PG,Katharios P,Flemetakis E

更新日期：2016-11-14 00:00:00

abstract：:Burkholderia are highly evolved Gram-negative bacteria that primarily infect solipeds but are transmitted to humans by ingestion and cutaneous or aerosol exposures. Heightened concern over human infections of Burkholderia mallei and the very closely related species B. pseudomallei is due to the pathogens' proven effec...

journal_title：Frontiers in microbiology

authors： Whitlock GC,Robida MD,Judy BM,Qazi O,Brown KA,Deeraksa A,Taylor K,Massey S,Loskutov A,Borovkov AY,Brown K,Cano JA,Torres AG,Estes DM,Sykes KF

更新日期：2011-11-21 00:00:00

abstract：:Carbapenems are major antibiotics reserved to human medicine. This study aimed to investigate the mechanisms of carbapenem resistance of a selection of Pseudomonas aeruginosa veterinary strains from the French network Resapath. Thirty (5.7%) imipenem and/or meropenem non-susceptible P. aeruginosa of canine (n = 24), f...

journal_title：Frontiers in microbiology

authors： Haenni M,Bour M,Châtre P,Madec JY,Plésiat P,Jeannot K

更新日期：2017-09-29 00:00:00

abstract：:Due to the globally observed increase in antibiotic resistance of bacterial pathogens and the simultaneous decline in new antibiotic developments, the need for alternative inactivation approaches is growing. This is especially true for the treatment of infections with the problematic ESKAPE pathogens, which include En...

journal_title：Frontiers in microbiology

authors： Hoenes K,Bauer R,Meurle T,Spellerberg B,Hessling M

更新日期：2021-01-13 00:00:00

abstract：:Guanylate kinases (GKs), which convert guanosine monophosphate into guanosine diphosphate (GDP), are important for growth and mannose outer chain elongation of cell wall N-linked glycoproteins in yeast. Here, we identified the ortholog of Saccharomyces cerevisiae GK Guk1, named MoGuk1 and a novel family of fungal GKs ...

journal_title：Frontiers in microbiology

authors： Cai X,Zhang X,Li X,Liu M,Liu X,Wang X,Zhang H,Zheng X,Zhang Z

更新日期：2017-12-11 00:00:00

abstract：:In this article we compare the efficacy of different pharmacological agents (ranitidine, and omeprazole) to support phage transit from stomach to distal portions of the gastrointestinal tract in rats. We show that a temporal modification of environment in the animal stomach may protect Twort-like therapeutic antistaph...

journal_title：Frontiers in microbiology

authors： Międzybrodzki R,Kłak M,Jończyk-Matysiak E,Bubak B,Wójcik A,Kaszowska M,Weber-Dąbrowska B,Łobocka M,Górski A

更新日期：2017-03-23 00:00:00

abstract：:The Gram-positive anaerobic human pathogenic bacterium Atopobium vaginae causes most diagnosed cases of bacterial vaginosis as well as opportunistic infections in immunocompromised patients. In addition to its well-established role in carbohydrate metabolism, D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from Str...

journal_title：Frontiers in microbiology

authors： Querol-García J,Fernández FJ,Marin AV,Gómez S,Fullà D,Melchor-Tafur C,Franco-Hidalgo V,Albertí S,Juanhuix J,Rodríguez de Córdoba S,Regueiro JR,Vega MC

更新日期：2017-04-10 00:00:00

abstract：:Previously, we determined that diallyl disulfide (DADS) from garlic oil can inhibit Pseudomonas aeruginosa PAO1 pathogenic factors by inactivating the transcription of key genes from three quorum sensing (QS) systems (las, rhl, and pqs) based on the effects of DADS on growth, virulence factor production (elastase, pyo...

journal_title：Frontiers in microbiology

authors： Li WR,Ma YK,Xie XB,Shi QS,Wen X,Sun TL,Peng H

更新日期：2019-01-07 00:00:00

abstract：:The estuarine nitrogen cycle can be substantially altered due to anthropogenic activities resulting in increased amounts of inorganic nitrogen (mainly nitrate). In the past, denitrification was considered to be the main ecosystem process removing reactive nitrogen from the estuarine ecosystem. However, recent reports ...

journal_title：Frontiers in microbiology

authors： Decleyre H,Heylen K,Van Colen C,Willems A

更新日期：2015-10-14 00:00:00

abstract：:Currently, sulfate-reducing bacteria (SRB) is regarded as the main culprit of microbiologically influenced corrosion (MIC), mainly due to the low reported corrosion rates of other microorganisms. For example, the highest reported corrosion rate for methanogens is 0.065 mm/yr. However, by investigating methanogen-induc...

journal_title：Frontiers in microbiology

authors： An BA,Kleinbub S,Ozcan O,Koerdt A

更新日期：2020-03-31 00:00:00

abstract：:Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion of ergosterol. Usi...

journal_title：Frontiers in microbiology

authors： Hu C,Zhou M,Wang W,Sun X,Yarden O,Li S

更新日期：2018-01-17 00:00:00

abstract：:Evolution of fungicide resistance in plant pathogens is one of major concerns in sustainable plant disease management. In this study, the genetics and potential of developing resistance to a demethylation inhibitor (DMI) fungicide, difenoconazole, in the fungal pathogen Alternaria alternata was investigated using a co...

journal_title：Frontiers in microbiology

authors： He MH,Wang YP,Wu EJ,Shen LL,Yang LN,Wang T,Shang LP,Zhu W,Zhan J

更新日期：2019-07-10 00:00:00

abstract：:The role of food in human exposure to antimicrobial-resistant bacteria is a growing food safety issue. The contribution of fruits and vegetables eaten raw to this exposure is still unclear. The evaluation of contamination levels of fruits, vegetables and the agricultural environment by third-generation cephalosporin (...

journal_title：Frontiers in microbiology

authors： Mesbah Zekar F,Granier SA,Marault M,Yaici L,Gassilloud B,Manceau C,Touati A,Millemann Y

更新日期：2017-08-24 00:00:00

abstract：:Multiple studies confirm laccase role in fungal pathogenicity and lignocellulose degradation. In spite of broad genomic research, laccases from plant wilt pathogen Fusarium oxysporum are still not characterized. The study aimed to identify F. oxysporum genes that may encode laccases sensu stricto and to characterize t...

journal_title：Frontiers in microbiology

authors： Kwiatos N,Ryngajłło M,Bielecki S

更新日期：2015-09-10 00:00:00