Comparative Functional Genomic Analysis of Two Vibrio Phages Reveals Complex Metabolic Interactions with the Host Cell.

abstract：:Fluoroquinolone resistance can cause major clinical problems. Here, we investigated fluoroquinolone resistance mechanisms in a clinical Escherichia coli isolate, HUE1, which had no mutations quinolone resistance-determining regions (QRDRs) of DNA gyrase and topoisomerase IV. HUE1 demonstrated MICs that exceeded the br...

journal_title：Frontiers in microbiology

authors： Sato T,Yokota S,Uchida I,Okubo T,Usui M,Kusumoto M,Akiba M,Fujii N,Tamura Y

更新日期：2013-05-24 00:00:00

abstract：:Human cytomegalovirus (HCMV) is the prototypic beta-herpesvirus and widespread throughout the human population. While infection is asymptomatic in healthy individuals, it can lead to high morbidity and mortality in immunocompromised persons. Importantly, HCMV evolved multiple strategies to interfere with immune cell f...

journal_title：Frontiers in microbiology

authors： Heilingloh CS,Grosche L,Kummer M,Mühl-Zürbes P,Kamm L,Scherer M,Latzko M,Stamminger T,Steinkasserer A

更新日期：2017-02-01 00:00:00

abstract：:The alarming spread of bacterial resistance to traditional antibiotics has warranted the study of alternative antimicrobial agents. Quorum sensing (QS) is a chemical cell-to-cell communication mechanism utilized by bacteria to coordinate group behaviors and establish infections. QS is integral to bacterial survival, a...

journal_title：Frontiers in microbiology

authors： Miller KP,Wang L,Chen YP,Pellechia PJ,Benicewicz BC,Decho AW

更新日期：2015-03-10 00:00:00

abstract：:Intertidal microbial mats are comprised of distinctly colored millimeter-thick layers whose communities organize in response to environmental gradients such as light availability, oxygen/sulfur concentrations, and redox potential. Here, slight changes in depth correspond to sharp niche boundaries. We explore the patte...

journal_title：Frontiers in microbiology

authors： Armitage DW,Gallagher KL,Youngblut ND,Buckley DH,Zinder SH

更新日期：2012-08-10 00:00:00

abstract：:Pathogens have evolved mechanisms to modulate host cell functions and avoid recognition and destruction by the host damage response. For many years, researchers have focused on proteins as the main effectors used by pathogens to hijack host cell pathways, but only recently with the development of deep RNA sequencing t...

journal_title：Frontiers in microbiology

authors： Bayer-Santos E,Marini MM,da Silveira JF

更新日期：2017-03-21 00:00:00

abstract：:Interactions with microbes affect many aspects of animal biology, including immune system development, nutrition and health. In vertebrates, the gut microbiota is dominated by a small subset of phyla, but the species composition within these phyla is typically not conserved. Moreover, several recent studies have shown...

journal_title：Frontiers in microbiology

authors： Ellegaard KM,Engel P

更新日期：2016-09-21 00:00:00

abstract：:Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recommended for HIV patients concurrently receiving protease inhibitors because of red...

journal_title：Frontiers in microbiology

authors： Rukasha I,Said HM,Omar SV,Koornhof H,Dreyer AW,Musekiwa A,Moultrie H,Hoosen AA,Kaplan G,Fallows D,Ismail N

更新日期：2016-12-05 00:00:00

abstract：:Twenty-three Saccharomyces cerevisiae strains isolated from different fermented foods of Western Himalayas have been studied for strain level and functional diversity in our department. Among these 23 strains, 10 S. cerevisiae strains on the basis of variation in their brewing traits were selected to study their organ...

journal_title：Frontiers in microbiology

authors： Kanwar SS,Keshani

更新日期：2016-06-28 00:00:00

abstract：:The Deepwater Horizon (DWH) blowout resulted in oil transport, including polycyclic aromatic hydrocarbons (PAHs) to the Gulf of Mexico shoreline. The microbial communities of these shorelines are thought to be responsible for the intrinsic degradation of PAHs. To investigate the Gulf Coast beach microbial community re...

journal_title：Frontiers in microbiology

authors： Kappell AD,Wei Y,Newton RJ,Van Nostrand JD,Zhou J,McLellan SL,Hristova KR

更新日期：2014-05-09 00:00:00

abstract：:The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this study, we focused on the N-terminal domain (NTD), which is mainly involved into protein oligomerization process, fo...

journal_title：Frontiers in microbiology

authors： Sala M,Spensiero A,Esposito F,Scala MC,Vernieri E,Bertamino A,Manfra M,Carotenuto A,Grieco P,Novellino E,Cadeddu M,Tramontano E,Schols D,Campiglia P,Gomez-Monterrey IM

更新日期：2016-06-10 00:00:00

abstract：:Toxoplasma gondii rhoptry proteins (TgROPs) are the major targets as key molecules for immunodiagnosis as well as immunoprophylaxis because of their initial presentation to the host immune system. In this work, it was aimed at evaluating the protection effect of TgROP21 DNA vaccine on experimental mice subjected to T....

journal_title：Frontiers in microbiology

authors： Zhang Z,Li Y,Wang M,Xie Q,Li P,Zuo S,Kong L,Wang C,Wang S

更新日期：2018-05-08 00:00:00

abstract：:Glycerol is one of the most important by-products of alcohol fermentation, and depending on its concentration it can contribute to wine flavor intensity and aroma volatility. Here, we evaluated the potential of utilizing the natural genetic variation of non-coding regions in budding yeast to identify allelic variants ...

journal_title：Frontiers in microbiology

authors： Tapia SM,Cuevas M,Abarca V,Delgado V,Rojas V,García V,Brice C,Martínez C,Salinas F,Larrondo LF,Cubillos FA

更新日期：2018-07-03 00:00:00

abstract：:Kunu is a traditional fermented single or mixed cereals-based beverage popularly consumed in many parts of West Africa. Presently, the bacterial community and mycotoxin contamination profiles during processing of various kunu formulations have never been comprehensively studied. This study, therefore, investigated the...

journal_title：Frontiers in microbiology

authors： Ezekiel CN,Ayeni KI,Ezeokoli OT,Sulyok M,van Wyk DAB,Oyedele OA,Akinyemi OM,Chibuzor-Onyema IE,Adeleke RA,Nwangburuka CC,Hajšlová J,Elliott CT,Krska R

更新日期：2019-01-09 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) regulate gene expression at the epigenetic, transcriptional, or posttranscriptional level by interacting with protein, DNA, and RNA. Emerging evidence suggests that various lncRNAs are abnormally expressed and play indispensable roles in virus-triggered cancers. Besides, a growing number...

journal_title：Frontiers in microbiology

authors： Liu W,Zhang Y,Luo B

更新日期：2021-01-15 00:00:00

abstract：:Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required. Interfering with Quorum Sensing (QS), a cell-to-cell communication system, has shown to be highly e...

journal_title：Frontiers in microbiology

authors： Allegretta G,Maurer CK,Eberhard J,Maura D,Hartmann RW,Rahme L,Empting M

更新日期：2017-05-24 00:00:00

abstract：:Most antibiotics are produced by soil microbes and typically interfere with macromolecular synthesis processes as their antibacterial mechanism of action. These natural products are often large and suffer from poor chemical tractability. Here, we discuss discovery, mechanism of action, and the therapeutic potentials o...

journal_title：Frontiers in microbiology

authors： Negatu DA,Gengenbacher M,Dartois V,Dick T

更新日期：2020-10-27 00:00:00

abstract：:This study presents three novel integrons In1394, In1395, and In1443, three novel unit transposons Tn6392, Tn6393, and Tn6403, one novel conjugative element (ICE) Tn6413, and the first sequenced IncP-7 resistance plasmid p1160-VIM from clinical Pseudomonas aeruginosa. Detailed sequence comparison of p1160-VIM (carryin...

journal_title：Frontiers in microbiology

authors： Zeng L,Zhan Z,Hu L,Jiang X,Zhang Y,Feng J,Gao B,Zhao Y,Yang W,Yang H,Yin Z,Zhou D

更新日期：2019-02-26 00:00:00

abstract：:Biofilms are the dominant form of microbial loading (and organic material) within drinking water distribution systems (DWDS), yet our understanding of DWDS microbiomes is focused on the more easily accessible bulk-water. Disinfectant residuals are commonly provided to manage planktonic microbial activity in DWDS to sa...

journal_title：Frontiers in microbiology

authors： Fish KE,Boxall JB

更新日期：2018-10-23 00:00:00

abstract：:Staphylococci are a group of microorganisms that can be often found in processed food and they might pose a risk for human health. In this study we have determined the content of staphylococci in 7 different fresh goat-milk cheeses. These bacteria were present in all of them, ranging from 103 to 106 CFU/g based on gro...

journal_title：Frontiers in microbiology

authors： Perales-Adán J,Rubiño S,Martínez-Bueno M,Valdivia E,Montalbán-López M,Cebrián R,Maqueda M

更新日期：2018-06-12 00:00:00

abstract：:Due to the high incidence of nosocomial Candida albicans infection, the first-line drugs for C. albicans infection have been heavily used, and the emergence of drug-resistant strains has gradually increased. Thus, a new antifungal drug or therapeutic method is needed. Chitosan, a product of chitin deacetylation, is co...

journal_title：Frontiers in microbiology

authors： Shih PY,Liao YT,Tseng YK,Deng FS,Lin CH

更新日期：2019-03-26 00:00:00

abstract：:Two-component regulatory systems (TCSSs) are key regulatory elements responsible for the adaptation of bacteria to environmental stresses. A classical TCSS is typically comprised of a sensory histidine kinase and a corresponding response regulator. Here, we used homologous recombination to construct a Mycobacterium sm...

journal_title：Frontiers in microbiology

authors： Dadura K,Płocińska R,Rumijowska-Galewicz A,Płociński P,Żaczek A,Dziadek B,Zaborowski A,Dziadek J

更新日期：2017-11-03 00:00:00

abstract：:We performed a study to (i) investigate efficacy of an Escherichia coli/Salmonella spp./Listeria monocytogenes-targeting bacteriophage cocktail (tentatively named F.O.P.) to reduce a human pathogenic E. coli strain O157:H7 in experimentally infected mice, and (ii) determine how bacteriophages impact the normal gut mic...

journal_title：Frontiers in microbiology

authors： Dissanayake U,Ukhanova M,Moye ZD,Sulakvelidze A,Mai V

更新日期：2019-09-10 00:00:00

abstract：:Pseudomonas aeruginosa (PA) is the leading cause of corneal blindness worldwide. A constant increase in multi-drug resistant PA strains have heightened the challenge of effectively managing corneal infections with conventional antibiotics. Antimicrobial peptides are promising antibiotic analogs with a unique mode of a...

journal_title：Frontiers in microbiology

authors： Mohammed I,Said DG,Nubile M,Mastropasqua L,Dua HS

更新日期：2019-09-19 00:00:00

abstract：:Thawing of permafrost soils is expected to stimulate microbial decomposition and respiration of sequestered carbon. This could, in turn, increase atmospheric concentrations of greenhouse gasses, such as carbon dioxide and methane, and create a positive feedback to climate warming. Recent metagenomic studies suggest th...

journal_title：Frontiers in microbiology

authors： Coolen MJ,Orsi WD

更新日期：2015-03-16 00:00:00

abstract：:The Deepwater Horizon accident has brought oil contamination of deep-sea environments to worldwide attention. The risk for new deep-sea spills is not expected to decrease in the future, as political pressure mounts to access deep-water fossil reserves, and poorly tested technologies are used to access oil. This also a...

journal_title：Frontiers in microbiology

authors： Scoma A,Yakimov MM,Boon N

更新日期：2016-08-03 00:00:00

abstract：:During the diauxic shift, Escherichia coli exhausts glucose and adjusts its expression pattern to grow on a secondary carbon source. Transcriptional profiling studies of glucose-lactose diauxic transitions reveal a key role for ppGpp. The amount of ppGpp depends on RelA synthetase and the balance between a strong SpoT...

journal_title：Frontiers in microbiology

authors： Fernández-Coll L,Cashel M

更新日期：2018-08-03 00:00:00

abstract：:A library of 14 minimally cytotoxic diterpenoid-like compounds (CC50 > 70 μM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus, and Escherichia coli to determine antimicrobial activity. Some compounds with a phenethyl alcohol (PE) core substituted with a β-cyclocitral deri...

journal_title：Frontiers in microbiology

authors： Crusco A,Baptista R,Bhowmick S,Beckmann M,Mur LAJ,Westwell AD,Hoffmann KF

更新日期：2019-06-25 00:00:00

abstract：:Biofilms are assemblages of microorganisms attached to each other, or to a surface, and encased in a protective, self-produced matrix. Such associations are now recognized as the predominant microbial growth mode. The physiology of cells in biofilms differs from that of the planktonic cells on which most research has ...

journal_title：Frontiers in microbiology

authors： Penesyan A,Paulsen IT,Gillings MR,Kjelleberg S,Manefield MJ

更新日期：2020-09-02 00:00:00

abstract：:Bacteria sense their own population size, tune the expression of responding genes, and behave accordingly to environmental stimuli by secreting signaling molecules. This phenomenon is termed as quorum sensing (QS). By exogenously manipulating the signal transduction bacterial population behaviors could be controlled, ...

journal_title：Frontiers in microbiology

authors： Chan KG,Liu YC,Chang CY

更新日期：2015-10-19 00:00:00

abstract：:In this study, we explore the virulence of vesicular stomatitis New Jersey virus (VSNJV) in pigs and its potential relationship with the virus's ability to modulate innate responses. For this purpose, we developed a mutant of the highly virulent strain NJ0612NME6, containing a single amino acid substitution in the mat...

journal_title：Frontiers in microbiology

authors： Velazquez-Salinas L,Pauszek SJ,Holinka LG,Gladue DP,Rekant SI,Bishop EA,Stenfeldt C,Verdugo-Rodriguez A,Borca MV,Arzt J,Rodriguez LL

更新日期：2020-05-29 00:00:00