Genetic Characterization of a bla VIM-24-Carrying IncP-7β Plasmid p1160-VIM and a bla VIM-4-Harboring Integrative and Conjugative Element Tn6413 From Clinical Pseudomonas aeruginosa.

Abstract:

:This study presents three novel integrons In1394, In1395, and In1443, three novel unit transposons Tn6392, Tn6393, and Tn6403, one novel conjugative element (ICE) Tn6413, and the first sequenced IncP-7 resistance plasmid p1160-VIM from clinical Pseudomonas aeruginosa. Detailed sequence comparison of p1160-VIM (carrying Tn6392 and Tn6393) and Tn6413 (carrying Tn6403) with related elements were performed. Tn6392, Tn6393, and Tn6403 were generated from integration of In1394 (carrying blaVIM-24), In1395 and In1443 (carrying blaVIM-4) into prototype Tn3-family unit transposons Tn5563, Tn1403, and Tn6346, respectively. To the best of our knowledge, this is the first report of a blaVIM-24-carrying P. aeruginosa isolate.

journal_name

Front Microbiol

authors

Zeng L,Zhan Z,Hu L,Jiang X,Zhang Y,Feng J,Gao B,Zhao Y,Yang W,Yang H,Yin Z,Zhou D

doi

10.3389/fmicb.2019.00213

subject

Has Abstract

pub_date

2019-02-26 00:00:00

pages

213

issn

1664-302X

journal_volume

10

pub_type

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