Abstract：
OBJECTIVES:To identify treatment-related toxicities that are either more frequent or more severe in the adolescent and young adult (AYA) oncology population. To explore differences in drug pharmacology and patient physiology that contribute to toxicities in the AYA population and to describe the impact of treatment-related toxicities on outcomes for AYA patients. DATA SOURCES:A PubMed search was undertaken using the key words Adolescent Young Adult Oncology, AYA, toxicity, bone marrow transplant, late effects, and chemotherapy. Additional toxicity information was also obtained from recent publications from cancer cooperative groups treating AYA patients. CONCLUSION:AYA patients often experience more severe toxicities than children when treated with identical chemotherapy regimens, which can interfere with successful administration of planned treatment, as well as have profound effects on quality of life. AYA patients with cancer face the dual challenge of disease biology associated with inferior response to treatment, thus necessitating treatment intensification, while at the same time suffering higher rates of specific toxicities such as vincristine-induced neuropathy, osteonecrosis, and treatment-related mortality caused by infection. IMPLICATIONS FOR NURSING PRACTICE:AYA patients are at a higher risk for toxicities from regimens that may be tolerated by younger patients. Staff should be aware of toxicities facing this population so that appropriate supportive care measures can be utilized. Future research on the pharmacology of drugs in adolescence, hormonal effects on drug-metabolizing enzymes, cumulative exposure to different drugs in combination, and risk and severity of specific toxicities will be critical to improving the treatment of AYA patients.
journal_name
Semin Oncol Nursjournal_title
Seminars in oncology nursingauthors
Bukowinski AJ,Burns KC,Parsons K,Perentesis JP,O'Brien MMdoi
10.1016/j.soncn.2015.05.003subject
Has Abstractpub_date
2015-08-01 00:00:00pages
216-26issue
3eissn
0749-2081issn
1878-3449pii
S0749-2081(15)00045-5journal_volume
31pub_type
杂志文章,评审abstract：OBJECTIVES:To identify key educational and scientific tasks for the incorporation of complementary and alternative medical therapies (CAM) into conventional health care. DATA SOURCES:Journal articles, government and special health report, book chapters, and curriculum guidebooks. CONCLUSION:Nursing education programs...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2005.04.011
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVES:To provide a review of the nursing committees in both the Children's Cancer Group and the Pediatric Oncology Group and discuss intergroup nursing research collaboration in preparation for the merger of these cooperative clinical trials groups. DATA SOURCES:Review articles, reports, and newsletters from coop...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1053/sonu.2000.16576
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVES:To examine patterns and trends in lung cancer and the risk factors associated with development of this disease. DATA SOURCES:Epidemiologic studies, research studies, review articles, and government reports pertaining to epidemiology of lung cancer. CONCLUSION:Epidemiological evidence documents that most lu...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/s0749-2081(96)80023-4
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVES:To examine the physiology and pathophysiology of loss of hair, the impact of alopecia on the patient, nursing and self-care interventions, and available resources. DATA SOURCES:Published articles pertaining to alopecia and personal experiences of coping with alopecia. CONCLUSIONS:Hair loss often is the mos...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/s0749-2081(05)80003-8
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVES:To summarize the challenges of teaching, practicing, and learning palliative care communication and offer resources for improving skills and educating others. DATA SOURCES:A theoretically grounded, evidence-based communication curriculum called COMFORT (Communication, Orientation and opportunity, Mindful pr...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2014.08.010
更新日期：2014-11-01 00:00:00
abstract：:This introduction lays the groundwork for this issue on a Collection of Oncology Nurses' Position Papers. Position papers developed by professional nursing organizations reflect a theoretical and research foundation. The position papers in this collection are relevant to oncology nurses in various practice settings an...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：10.1053/j.soncn.2004.02.001
更新日期：2004-05-01 00:00:00
abstract：:The diagnosis and initial treatment of a parent for cancer is a highly stressful process that generates a variety of concerns for adult children. This study describes the initial effect of a parent's cancer on adult children. Adult children's concerns about role and relationship issues emerged as major themes in the c...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：10.1016/s0749-2081(05)80105-6
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:To summarize the scientific principles underlying cancer prevention. DATA SOURCES:Articles, text books, personal communications, and experience. CONCLUSION:The scientific basis of cancer prevention is complex and involves experimental and epidemiologic approaches and clinical trials. IMPLICATIONS FOR NURSI...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2005.06.002
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVES:To provide a comprehensive summary of the coping strategies and evidence-based interventions used to address cognitive impairment following cancer and cancer treatment. DATA SOURCES:Review and synthesis of empirical articles. CONCLUSION:Survivors identified a structured environment and validation of their ...
journal_title：Seminars in oncology nursing
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doi：10.1016/j.soncn.2013.08.009
更新日期：2013-11-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2007.10.002
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To provide an overview of hereditary cancer susceptibility genes and associated cancer risks. DATA SOURCES:Peer reviewed published research studies and review articles. CONCLUSIONS:Identifying deleterious mutations in cancer susceptibility genes allows for clarification of cancer risk in individual family m...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2010.11.004
更新日期：2011-02-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2011.07.009
更新日期：2011-11-01 00:00:00
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journal_title：Seminars in oncology nursing
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doi：10.1016/j.soncn.2019.150982
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:To describe the scope of home infusion therapy in cancer care, expectations related to caregiver involvement in home infusion therapy, literature addressing the impact upon caregivers, and nursing implications. DATA SOURCES:Published data on cancer care and home infusion therapy. CONCLUSION:While the admin...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2019.06.010
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVES:To describe the various models of acute and chronic pain used in animal research and to assist the clinical nurse to understand specific terminology in interpreting the research findings. DATA SOURCES:Review articles, book chapters, research studies, and research guidelines and handbooks pertaining to use o...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/s0749-2081(97)80043-5
更新日期：1997-02-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：OBJECTIVES:To provide an overview of colorectal carcinoma (CRC), including current treatment strategies for various stages of the disease. DATA SOURCES:Research articles and textbooks. CONCLUSIONS:Despite screening methods for early detection of CRC, many patients present with late-stage disease and have a poor progn...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1053/sonu.2002.33074
更新日期：2002-05-01 00:00:00
abstract：:Some of the special concerns of the dying patient have been addressed. Loss of control, adequate pain control, and sexuality represent only a small portion of the enormity of caring for dying patients. Great strides have been made in recent years both in the areas of special concerns and recognizing the anticipatory g...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：10.1016/0749-2081(89)90071-5
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:To review ethical, legal, and social implications of genomics, a ground-breaking science that when applied improves cancer care outcomes. DATA SOURCES:PubMed, Cumulative Index to Nursing and Allied Health (CINAHL), Cochrane Library, consensus statements, and professional guidelines. CONCLUSION:Ethical, lega...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2018.12.007
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVES:To review nursing science history within the Gynecology Oncology Group (GOG); to discuss challenges of nursing science in the cooperative group (CG) using a current nurse-led protocol (GOG-0259) as an exemplar; and to propose recommendations to advance nursing science in the CG setting. DATA SOURCES:Indexed...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：10.1016/j.soncn.2013.12.008
更新日期：2014-02-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/s0749-2081(03)00048-2
更新日期：2003-08-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/0749-2081(91)90033-l
更新日期：1991-08-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：10.1016/j.soncn.2016.02.007
更新日期：2016-05-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2018.10.014
更新日期：2018-12-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/s0749-2081(96)80007-6
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVES:To define and distinguish informed decision-making (IDM) from shared decision-making (SDM) and review the evidence for technology-based interventions designed to facilitate informed decisions about cancer screening and treatment. DATA SOURCES:Peer-reviewed research articles from Medline and other data sourc...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章
doi：10.1016/j.soncn.2011.04.004
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVES:To provide a review of genetic biomarkers of cancer risk and associated clinical implications. DATA SOURCES:Published literature, evidence-based guidelines. CONCLUSION:Identification of the genetic variation associated with cancer risk enables the health care provider to stratify an individual's risk and p...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2012.03.007
更新日期：2012-05-01 00:00:00
abstract：:Over the past 20 years, advances in tumor staging, tumor biology, and therapeutic management have positively influenced both cure rates and overall survival of patients with bladder cancer. Treatment recommendations depend on the stage of the disease, the grade of tumor, likelihood of recurrence, and the patient's med...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/s0749-2081(05)80053-1
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:To present an overview of novel therapies for the treatment of adult acute lymphoblastic leukemia and to discuss nursing implications for these new therapies. DATA SOURCES:Published manuscripts, Web sites, and pharmaceutical package inserts. CONCLUSION:Several promising therapies have emerged in the treatme...
journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2019.150951
更新日期：2019-12-01 00:00:00
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journal_title：Seminars in oncology nursing
pub_type： 杂志文章,评审
doi：10.1016/j.soncn.2018.03.010
更新日期：2018-05-01 00:00:00
