Abstract:
BACKGROUND:Clinical implications of subclinical hypothyroidism (SCH) are still matter of intense debate, resulting in the controversial discussion whether subclinical hypothyroidism should be treated. We performed a cohort study to evaluate the impact of subclinical hypothyroidism on vascular and overall mortality. METHODS:Between 02/1993 and 03/2004, a total of 103,135 persons attending the General Hospital Vienna with baseline serum thyrotropin (TSH, thyroid-stimulating hormone) and free thyroxin (fT4) measurements could be enrolled in a retrospective cohort study. Subclinical hypothyroidism was defined by elevated TSH ranging from 4.5 to 20.0 mIU/L and normal fT4 concentration (0.7-1.7 ng/dL). Overall and vascular mortality as primary endpoints were assessed via record linkage with the Austrian Death Registry. RESULTS:A total of 80,490 subjects fulfilled inclusion criteria of whom 3934 participants (3.7%) were classified as SCH (868 males and 3066 females, median age 48 years). The mean follow-up among the 80,490 subjects was 4.1 years yielding an observation period of 373,301 person-years at risk. In a multivariate Cox regression model adjusted for age and gender TSH levels showed a dose-dependent association with all-cause mortality. The association between SCH and overall or vascular mortality was stronger in men below 60 years compared to older males or females. CONCLUSION:Our data support the hypothesis that SCH might represent an independent risk factor for overall and vascular mortality, especially in men below 60 years. Whether this group would benefit from replacement therapy should be evaluated in interventional studies.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Kovar FM,Fang IF,Perkmann T,Haslacher H,Slavka G,Födinger M,Endler G,Wagner OFdoi
10.1007/s00508-015-0846-zsubject
Has Abstractpub_date
2015-12-01 00:00:00pages
924-30issue
23-24eissn
0043-5325issn
1613-7671pii
10.1007/s00508-015-0846-zjournal_volume
127pub_type
杂志文章abstract:OBJECTIVE:The aim of our study was to determine whether a difference exists in expression of corticotropin-releasing hormone receptor-R1 (CRH-R1) and corticotropin-releasing hormone receptor-R2 (CRH-R2) in fetal membranes of preterm and term women with or without labor. MATERIAL AND METHODS:Small pleces of fetal membr...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2002-12-30 00:00:00
abstract:BACKGROUND:The PX-104 is an oral non-steroidal agonist for the farnesoid X receptor (FXR), a key regulator of bile acid (BA), glucose and lipid homeostasis. AIMS AND METHODS:This single center, proof of concept study evaluated the efficacy, safety and tolerability of PX-104 in non-diabetic NAFLD patients. 12 individua...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Prolonged pregnancy is the most frequent reason for induction of labor. This study aims to determine the effects of labor induction on delivery outcome and to quantify the risks of cesarean delivery associated with labor induction in post-date pregnancies. PATIENTS AND METHODS:This retrospective case-contro...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-005-0330-2
更新日期:2005-04-01 00:00:00
abstract::Since the introduction of peritoneal dialysis (PD) into clinical nephrology at the end of the 1970s, many improvements have led to acceptance of this method as renal replacement therapy equivalent to hemodialysis. It is unclear whether the diabetic patient is the ideal candidate for PD and if this procedure should be ...
journal_title:Wiener klinische Wochenschrift
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更新日期:2005-01-01 00:00:00
abstract::Despite the administration of antimalarial treatment, severe malaria still has a high mortality rate. Since overall survival is associated with total parasite biomass, whole blood exchange (e.g. blood exchange transfusions) has been proposed as a potential method to rapidly reduce peripheral parasitaemia. Automated re...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/s00508-012-0238-6
更新日期:2012-11-01 00:00:00
abstract::Self monitoring of blood glucose contributes to the integrated management of diabetes mellitus. It, thus, should be available for all patients with diabetes mellitus type-1 and type-2. Self monitoring of blood glucose improves patients safety, quality of life and glucose control. The current article represents the rec...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-012-0288-9
更新日期:2012-12-01 00:00:00
abstract::In this study 36 patients with cardiac phobia were examined prior to hospitalisation and 29 of them were re-examined after 2.5 years. An analysis of the clinical pictures showed that all of the patients met the DSM III criteria for panic disorder. The follow-up results indicated that the anxiety attacks often recurred...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:1987-08-28 00:00:00
abstract::An assessment of the value of hysterosalpingography (HSG) and laparoscopy was made on the basis of a comparison of the respective findings obtained during routine investigation of 105 women attending the Infertility Clinic. The results of the two procedures concurred in 76% of the women; in the remaining cases, appare...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:1978-02-17 00:00:00
abstract::The endocrine management of advanced breast cancer is of great clinical importance. Apart from the known therapeutic approach with oestrogens, androgens, gestagens and steroids, the oestrogen antagonist, tamoxifen appears to be a promising therapeutic agent. In this study from October 1st, 1975, to October 1st, 1976, ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-02-17 00:00:00
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journal_title:Wiener klinische Wochenschrift
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:1987-01-09 00:00:00
abstract::In a prospective study comprising 48 children (21 boys, 27 girls, age 12 months to 15 years) the hypothesis was tested whether an alteration in the light chain immunoglobulins kappa (kappa) and lambda (lambda) is an expression of autoimmune mechanisms and could be used as a diagnostic parameter. Immunoglobulins were a...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1990-04-13 00:00:00
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journal_title:Wiener klinische Wochenschrift
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更新日期:2006-08-01 00:00:00
abstract::In an extensive series of experimental studies conducted on the common carotid artery in rats, a combined technique involving suture and gluing with human fibrin glue has been developed. In view of the good results achieved, this technique was then applied in 12 patients in whom anastomosis between the superficial tem...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-06-09 00:00:00
abstract::Hyperuicaemia is a frequent finding in psoriasis vulgaris. Enhanced purine catabolism due to the rapid turnover of psoriatric epidermis is thought to be the cause of the raised serum uric acid levels. In the present study serum acid determinations were performed in 197 patients with psoriasis vulgaris. Since no correl...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-04-28 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,已发布勘误
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更新日期:2018-06-01 00:00:00
abstract::A well-defined, characteristic disease has been observed in babies at the Department of Dermatology, Innsbruck University, over the past 7 years. On account of the localisation and probable pathogenesis of the condition the term "Windelsoor" (napkin thrush) has been coined by us for it. The clinical picture, the mycol...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1975-03-07 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
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journal_title:Wiener klinische Wochenschrift
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journal_title:Wiener klinische Wochenschrift
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更新日期:2015-01-01 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Wiener klinische Wochenschrift
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更新日期:2011-02-01 00:00:00
abstract::Thirty four children, aged 2 to 15 years, were treated by haemodialysis between 1967 and 1978. Eleven children suffered from acute renal failure. Twenty three children with end-stage chronic renal disease were treated over periods ranging from 1 week to 19 months. All children were dialysed in a renal unit for adult p...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:1980-01-18 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:1976-10-15 00:00:00
abstract::187 patients were checked up over 4 years by the secretin-ceruletide test. Independently of the test results they were assigned to various disease groups on the basis of clinical assessment. 131 subjects were divided in a pilot investigation into: subjects with a healthy pancreas (n = 55); subjects with chronic pancre...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
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更新日期:2002-01-15 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Encouraging results in transplant medicine create a growing demand for organ transplant donors. Transcranial Doppler (TCD) has been used by several investigators to assess arrest of the cerebral circulation in brain dead patients. We report on TCD as a monitoring tool for early identification of potential or...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1997-11-14 00:00:00