Immunogenetics of HLA.

Abstract:

:The enormous contributions of Professor Karl Landsteiner are summarized focusing on his discovery of the ABO, MN, and P blood group systems as well as his conceptualization of the hapten concept. The HLA system, the major histocompatibility complex in humans, is discussed from the point of view of its genetic organization, the polymorphism that is recognized by T lymphocytes and the presently defined molecular polymorphism. The structure-function relationship of T cell recognition of class II molecules, based on the known crystallographic structure of an HLA class I molecule, is presented.

journal_name

Wien Klin Wochenschr

authors

Bach FH

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

141-5

issue

5

eissn

0043-5325

issn

1613-7671

journal_volume

103

pub_type

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