Targeted metagenomics unveils the molecular basis for adaptive evolution of enzymes to their environment.

Abstract:

:Microorganisms have a wonderful ability to adapt rapidly to new or altered environmental conditions. Enzymes are the basis of metabolism in all living organisms and, therefore, enzyme adaptation plays a crucial role in the adaptation of microorganisms. Comparisons of homology and parallel beneficial mutations in an enzyme family provide valuable hints of how an enzyme adapted to an ecological system; consequently, a series of enzyme collections is required to investigate enzyme evolution. Targeted metagenomics is a promising tool for the construction of enzyme pools and for studying the adaptive evolution of enzymes. This perspective article presents a summary of targeted metagenomic approaches useful for this purpose.

journal_name

Front Microbiol

authors

Suenaga H

doi

10.3389/fmicb.2015.01018

subject

Has Abstract

pub_date

2015-09-22 00:00:00

pages

1018

issn

1664-302X

journal_volume

6

pub_type

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