Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility.

abstract：:Granulocytes mediate the first line of defense against infectious diseases in humans as well as animals and they are well known as multitasking cells. They can mediate antimicrobial activity by different strategies depending on the pathogen they encounter. Besides phagocytosis, a key strategy against extracellular pat...

journal_title：Frontiers in microbiology

authors： de Buhr N,Bonilla MC,Jimenez-Soto M,von Köckritz-Blickwede M,Dolz G

更新日期：2018-05-15 00:00:00

abstract：:Copper membrane monooxygenases (CuMMOs) oxidize ammonia, methane and some short-chain alkanes and alkenes. They are encoded by three genes, usually in an operon of xmoCAB. We aligned xmo operons from 66 microbial genomes, including members of the Alpha-, Beta-, and Gamma-proteobacteria, Verrucomicrobia, Actinobacteria...

journal_title：Frontiers in microbiology

authors： Khadka R,Clothier L,Wang L,Lim CK,Klotz MG,Dunfield PF

更新日期：2018-10-29 00:00:00

abstract：:Serratia marcescens has emerged as an important opportunistic pathogen responsible for nosocomial and severe infections. Here, we determined phenotypic and molecular characteristics of 54 S. marcescens isolates obtained from patient samples from intensive-care-unit (ICU) and neonatal intensive-care-unit (NIUC) of a Br...

journal_title：Frontiers in microbiology

authors： Ferreira RL,Rezende GS,Damas MSF,Oliveira-Silva M,Pitondo-Silva A,Brito MCA,Leonardecz E,de Góes FR,Campanini EB,Malavazi I,da Cunha AF,Pranchevicius MDS

更新日期：2020-05-20 00:00:00

abstract：:Incompatibility group C (IncC) plasmids have received attention due to their broad host range and because they harbor key antibiotic resistance genes. Because these resistance genes can spread from food-producing animals to human, the proliferation of these plasmids represents a public health risk. In this study, a to...

journal_title：Frontiers in microbiology

authors： Zhang Y,Lei CW,Chen X,Yao TG,Yu JW,Hu WL,Mao X,Wang HN

更新日期：2020-10-27 00:00:00

abstract：:The archaeon Thermococcus barophilus, one of the most extreme members of hyperthermophilic piezophiles known thus far, is able to grow at temperatures up to 103°C and pressures up to 80 MPa. We analyzed the membrane lipids of T. barophilus by high performance liquid chromatography-mass spectrometry as a function of pr...

journal_title：Frontiers in microbiology

authors： Cario A,Grossi V,Schaeffer P,Oger PM

更新日期：2015-10-21 00:00:00

abstract：:The Chlamydiaceae comprise a group of highly adapted bacterial pathogens sharing a unique intracellular lifestyle. Three Chlamydia species are pathogenic to humans: Chlamydia trachomatis, Chlamydia pneumoniae, and Chlamydia psittaci. C. trachomatis is the leading bacterial cause of sexually-transmitted infections and ...

journal_title：Frontiers in microbiology

authors： Panzetta ME,Valdivia RH,Saka HA

更新日期：2018-12-12 00:00:00

abstract：:Antibiotic resistance is a problem for human health, and consequently, its study had been traditionally focused toward its impact for the success of treating human infections in individual patients (individual health). Nevertheless, antibiotic-resistant bacteria and antibiotic resistance genes are not confined only to...

journal_title：Frontiers in microbiology

authors： Hernando-Amado S,Coque TM,Baquero F,Martínez JL

更新日期：2020-08-28 00:00:00

abstract：:It has been shown that infection of GB virus B (GBV-B), which is closely related to hepatitis C virus, develops acute self-resolving hepatitis in tamarins. In this study we sought to examine longitudinally the dynamics of viral and immunological status following GBV-B infection of marmosets and tamarins. Surprisingly,...

journal_title：Frontiers in microbiology

authors： Iwasaki Y,Mori K,Ishii K,Maki N,Iijima S,Yoshida T,Okabayashi S,Katakai Y,Lee YJ,Saito A,Fukai H,Kimura N,Ageyama N,Yoshizaki S,Suzuki T,Yasutomi Y,Miyamura T,Kannagi M,Akari H

更新日期：2011-12-07 00:00:00

abstract：:The objective of this study was to evaluate the effects of wilting and Lactobacillus plantarum (LP) addition on the silage fermentation quality and microbial community of Moringa oleifera Lam. leaf silage. Unwilted (direct-cut) or wilted M. oleifera leaves were prepared either with or without LP (1.0 × 106 cfu/g) foll...

journal_title：Frontiers in microbiology

authors： Wang Y,Wang C,Zhou W,Yang FY,Chen XY,Zhang Q

更新日期：2018-08-06 00:00:00

abstract：:Biosynthesis of nanoparticles (NPs) by microorganisms is a cost- and energy-effective approach. However, how the production of NPs affects the population of producing organism remains as an unresolved question. The present study aimed to evaluate the kinetics of Saccharomyces cerevisiae growth in relation to synthesis...

journal_title：Frontiers in microbiology

authors： Asghari-Paskiabi F,Imani M,Eybpoosh S,Rafii-Tabar H,Razzaghi-Abyaneh M

更新日期：2020-05-21 00:00:00

abstract：:Major foodborne bacterial pathogens, such as Campylobacter jejuni, have devised complex strategies to establish and foster intestinal infections. For more than two decades, researchers have used immortalized cell lines derived from human intestinal tissue to dissect C. jejuni-host cell interactions. Known from these s...

journal_title：Frontiers in microbiology

authors： Negretti NM,Clair G,Talukdar PK,Gourley CR,Huynh S,Adkins JN,Parker CT,Corneau CM,Konkel ME

更新日期：2019-04-11 00:00:00

abstract：:The gut microbiota plays an important role in host health, in particular by its barrier effect and competition with exogenous pathogenic bacteria. In the present study, the competition of Bifidobacterium pseudolongum PV8-2 (Bp PV8-2) and Bifidobacterium kashiwanohense PV20-2 (Bk PV20-2), isolated from anemic infant gu...

journal_title：Frontiers in microbiology

authors： Vazquez-Gutierrez P,de Wouters T,Werder J,Chassard C,Lacroix C

更新日期：2016-09-22 00:00:00

abstract：:Understanding how proteins evolve is important, and the order of amino acids being recruited into the genetic codons was found to be an important factor shaping the amino acid composition of proteins. The latest work about the last universal common ancestor (LUCA) makes it possible to determine the potential factors s...

journal_title：Frontiers in microbiology

authors： Du MZ,Zhang C,Wang H,Liu S,Wei W,Guo FB

更新日期：2018-12-07 00:00:00

abstract：:A microbiome is defined as a complex collection of microorganisms and their genetic material. Studies regarding gut microbiomes of different animals have provided ecological and evolutionary information showing a strong link between health and disease. Very few studies have compared the gut microbiota of animals house...

journal_title：Frontiers in microbiology

authors： Sandri C,Correa F,Spiezio C,Trevisi P,Luise D,Modesto M,Remy S,Muzungaile MM,Checcucci A,Zaborra CA,Mattarelli P

更新日期：2020-10-20 00:00:00

abstract：:Random transposon mutagenesis is a powerful technique used to generate libraries of genetic insertions in many different bacterial strains. Here we develop a system facilitating random transposon mutagenesis in a range of different Gram-negative bacterial strains, including Pectobacterium atrosepticum, Citrobacter rod...

journal_title：Frontiers in microbiology

authors： Monson R,Smith DS,Matilla MA,Roberts K,Richardson E,Drew A,Williamson N,Ramsay J,Welch M,Salmond GP

更新日期：2015-12-22 00:00:00

abstract：:Monascus purpureus YY-1 is widely used in food colorant production in China. Our previous study clearly illustrated the whole-genome data for YY-1 and provided useful insight into evolutionary research and industrial applications. However, the presence of citrinin, which has nephrotoxic, hepatotoxic, and carcinogenic ...

journal_title：Frontiers in microbiology

authors： Liang B,Du XJ,Li P,Sun CC,Wang S

更新日期：2018-06-28 00:00:00

abstract：:Agricultural ponds have a great potential as a means of capture and storage of water for irrigation. However, pond topography (small size, shallow depth) leaves them susceptible to environmental, agricultural, and anthropogenic exposures that may influence microbial dynamics. Therefore, the aim of this project was to ...

journal_title：Frontiers in microbiology

authors： Chopyk J,Allard S,Nasko DJ,Bui A,Mongodin EF,Sapkota AR

更新日期：2018-04-24 00:00:00

abstract：:Managed aquifer recharge (MAR) offers a collection of water storage and storage options that have been used by resource managers to mitigate the reduced availability of fresh water. One of these technologies is aquifer storage and recovery (ASR), where surface water is treated then recharged into a storage zone within...

journal_title：Frontiers in microbiology

authors： Lisle JT

更新日期：2020-07-29 00:00:00

abstract：:Previous studies on vancomycin-intermediate Staphylococcus aureus (VISA) have mainly focused on drug resistance, the evolution of differences in virulence between VISA and vancomycin-sensitive S. aureus (VSSA) requires further investigation. To address this issue, in this study, we compared the virulence and toxin pro...

journal_title：Frontiers in microbiology

authors： Jin Y,Yu X,Zhang S,Kong X,Chen W,Luo Q,Zheng B,Xiao Y

更新日期：2020-10-30 00:00:00

abstract：:We compared the bacterial microbiomes lodged in the bronchial tree, oropharynx and nose of patients with early stage cystic fibrosis (CF) not using chronic antibiotics, determining their relationships with lung function and exacerbation frequency. CF patients were enrolled in a cohort study during stability and were c...

journal_title：Frontiers in microbiology

authors： Garcia-Nuñez M,Garcia-Gonzalez M,Pomares X,Montón C,Millares L,Quero S,Prina E,Asensio O,Bosque M,Capilla S,Cuevas O,Monsó E

更新日期：2020-06-30 00:00:00

abstract：:The gastrointestinal microbiome is crucial in human health. With greater than 10 times the cell count of an individual, the gastrointestinal microbiome provides many benefits to the host. It plays an important role in chronic illnesses and immune diseases and also following burns and trauma. This study aimed to determ...

journal_title：Frontiers in microbiology

authors： Huang G,Sun K,Yin S,Jiang B,Chen Y,Gong Y,Chen Y,Yang Z,Chen J,Yuan Z,Peng Y

更新日期：2017-07-06 00:00:00

abstract：:Host population density is positively associated with the strength of social interactions or the frequency of physical contacts, and thus potentially influences microbial transmission among individuals. However, the relationship between host density and gut microbiota remains unknown. Here, we characterized the gut mi...

journal_title：Frontiers in microbiology

authors： Li H,Qu J,Li T,Li J,Lin Q,Li X

更新日期：2016-05-18 00:00:00

abstract：:Ecological understandings of soil bacterial community succession and assembly mechanism along elevational gradients in mountains remain not well understood. Here, by employing the high-throughput sequencing technique, we systematically examined soil bacterial diversity patterns, the driving factors, and community asse...

journal_title：Frontiers in microbiology

authors： Li J,Shen Z,Li C,Kou Y,Wang Y,Tu B,Zhang S,Li X

更新日期：2018-03-27 00:00:00

abstract：:In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureusΔmvaS mutant can revert to prototrophy. This mutant couldn't grow in the absence of MVA. However, after a long lag-phase of 4-6 days the mutant adapted from auxotrophic to prototrophic phenotype. During that time, it acquir...

journal_title：Frontiers in microbiology

authors： Reichert S,Ebner P,Bonetti EJ,Luqman A,Nega M,Schrenzel J,Spröer C,Bunk B,Overmann J,Sass P,François P,Götz F

更新日期：2018-07-12 00:00:00

abstract：:Zoonotic hepatitis E, mainly caused by hepatitis E virus (HEV) genotype (gt) 3, is a foodborne disease that has emerged in Europe in recent decades. The main animal reservoir for genotype 3 is domestic pigs. Pig liver and liver derivates are considered the major risk products, and studies focused on the presence of HE...

journal_title：Frontiers in microbiology

authors： García N,Hernández M,Gutierrez-Boada M,Valero A,Navarro A,Muñoz-Chimeno M,Fernández-Manzano A,Escobar FM,Martínez I,Bárcena C,González S,Avellón A,Eiros JM,Fongaro G,Domínguez L,Goyache J,Rodríguez-Lázaro D

更新日期：2020-01-28 00:00:00

abstract：:The Bay of Bengal (BoB) is the largest bay in the world and presents a unique marine environment that is subjected to severe weather, a distinct hydrographic regime and a large anthropogenic footprint. Despite these features and the BoB's overall economic significance, this ecosystem and its microbiome remain among th...

journal_title：Frontiers in microbiology

authors： Angelova AG,Ellis GA,Wijesekera HW,Vora GJ

更新日期：2019-12-06 00:00:00

abstract：:Apple by-products (ABP) underwent fermentation (48 h at 30°C, Fermented-ABP) with a selected binary culture of Weissella cibaria PEP23F and Saccharomyces cerevisiae AN6Y19. Compared to Raw-ABP and Chemically Acidified-ABP (CA-ABP), fermentation markedly increased the hydration properties of ABP. Fermentation led to th...

journal_title：Frontiers in microbiology

authors： Cantatore V,Filannino P,Gambacorta G,De Pasquale I,Pan S,Gobbetti M,Di Cagno R

更新日期：2019-11-06 00:00:00

abstract：:Bacillus pumilus 64-1, a bacterial strain isolated from the marine sponge Plakina cyanorosea, which exhibits antimicrobial activity against both pathogenic and drug-resistant Gram-positive and Gram-negative bacteria. This study aimed to conduct an in-depth genomic analysis of this bioactive sponge-derived strain. The ...

journal_title：Frontiers in microbiology

authors： Freitas-Silva J,de Oliveira BFR,Vigoder FM,Muricy G,Dobson ADW,Laport MS

更新日期：2021-01-08 00:00:00

abstract：:Denitrification and dissimilatory nitrate reduction to ammonium (DNRA) compete for nitrate in natural and engineered environments. A known important factor in this microbial competition is the ratio of available electron donor and elector acceptor, here expressed as Ac/N ratio (acetate/nitrate-nitrogen). We studied th...

journal_title：Frontiers in microbiology

authors： van den Berg EM,Boleij M,Kuenen JG,Kleerebezem R,van Loosdrecht MC

更新日期：2016-11-24 00:00:00

abstract：:Aflatoxins are highly toxic carcinogens that detrimentally influence profitability of agriculture and the health of humans and domestic animals. Several phylogenetically distinct fungi within Aspergillus section Flavi have S-morphology (average sclerotial size < 400 μm), and consistently produce high concentrations of...

journal_title：Frontiers in microbiology

authors： Singh P,Callicott KA,Orbach MJ,Cotty PJ

更新日期：2020-06-11 00:00:00