Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work.

abstract：:The development of whole-genome bisulfite sequencing (WGBS) has resulted in a number of exciting discoveries about the role of DNA methylation leading to a plethora of novel testable hypotheses. Methods for constructing sodium bisulfite-converted and amplified libraries have recently advanced to the point that the bot...

journal_title：Frontiers in genetics

authors： Ji L,Sasaki T,Sun X,Ma P,Lewis ZA,Schmitz RJ

更新日期：2014-10-21 00:00:00

abstract：:Genetic variants can influence the expression of mRNA and protein. Genetic regulatory loci such as expression quantitative trait loci (eQTLs) and protein quantitative trait loci (pQTLs) exist in several species. However, it remains unclear how human genetic variants regulate mRNA and protein expression. Here, we chara...

journal_title：Frontiers in genetics

authors： Wang Y,He B,Zhao Y,Reiter JL,Chen SX,Simpson E,Feng W,Liu Y

更新日期：2019-09-10 00:00:00

abstract：:Recently, cancer has been characterized as a heterogeneous disease composed of many different subtypes. Early diagnosis of cancer subtypes is an important study of cancer research, which can be of tremendous help to patients after treatment. In this paper, we first extract a novel dataset, which contains gene expressi...

journal_title：Frontiers in genetics

authors： Li S,Jiang L,Tang J,Gao N,Guo F

更新日期：2020-09-10 00:00:00

abstract：:Mutations in mitochondrial (mt) DNA determine important human diseases. The majority of the known pathogenic mutations are located in transfer RNA (tRNA) genes and are responsible for a wide range of currently untreatable disorders. Experimental evidence both in yeast and in human cells has shown that the detrimental ...

journal_title：Frontiers in genetics

authors： Giordano C,Morea V,Perli E,d'Amati G

更新日期：2015-03-23 00:00:00

abstract：:Satellite DNA is a class of repetitive sequences that are organized in long arrays of tandemly repeated units in most eukaryotes. Long considered as selfish DNA, satellite sequences are now proposed to contribute to genome integrity. Despite their potential impact on the architecture and evolution of the genome, satel...

journal_title：Frontiers in genetics

authors： Panabières F,Rancurel C,da Rocha M,Kuhn ML

更新日期：2020-06-05 00:00:00

abstract：:Growing evidences have indicated that microRNAs (miRNAs) play a significant role relating to many important bioprocesses; their mutations and disorders will cause the occurrence of various complex diseases. The prediction of miRNAs associated with underlying diseases via computational approaches is beneficial to ident...

journal_title：Frontiers in genetics

authors： Zhang Y,Chen M,Cheng X,Wei H

更新日期：2020-04-30 00:00:00

abstract：:Primary ciliary dyskinesia (PCD), a rare genetic disorder, is mostly caused by defects in more than 40 known cilia structure-related genes. However, in approximately 20-35% of patients, it is caused by unknown genetic factors, and the inherited pathogenic factors are difficult to confirm. Kartagener syndrome (KTS) is ...

journal_title：Frontiers in genetics

authors： Yue Y,Huang Q,Zhu P,Zhao P,Tan X,Liu S,Li S,Han X,Cheng L,Li B,Fu Y

更新日期：2019-08-22 00:00:00

abstract：:The Qinghai-Tibetan Plateau (QTP) is the highest and one of the most extensive plateaus in the world. Phylogenetic, phylogeographic, and ecological studies support plant diversifications on the QTP through multiple mechanisms such as allopatric speciation via geographic isolation, climatic oscillations and divergences...

journal_title：Frontiers in genetics

authors： Wen J,Zhang JQ,Nie ZL,Zhong Y,Sun H

更新日期：2014-02-12 00:00:00

abstract：:The systematic study of genotoxicity in plants induced by contaminants and other stress agents has been hindered to date by the lack of reliable and robust biomarkers. The comet assay is a versatile and sensitive method for the evaluation of DNA damages and DNA repair capacity at single-cell level. Due to its simplici...

journal_title：Frontiers in genetics

authors： Santos CL,Pourrut B,Ferreira de Oliveira JM

更新日期：2015-06-30 00:00:00

abstract：:Muscle weakness is a common consequence of both aging (sarcopenia) and neuromuscular disorders (NMD). Whilst genome-wide association (GWA) studies have identified genetic variants associated with grip strength (GS; measure of muscle strength/weakness) and NMDs, including multiple sclerosis (MS), myasthenia gravis (MG)...

journal_title：Frontiers in genetics

authors： Gokuladhas S,Schierding W,Cameron-Smith D,Wake M,Scotter EL,O'Sullivan J

更新日期：2020-04-24 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) play a regulatory role and influence various biological activities, such as cell proliferation, differentiation, and survival. Our group has demonstrated through functional studies that Schistosoma mansoni c-Jun N-terminal kinase (SmJNK) MAPK is involved in the parasite's deve...

journal_title：Frontiers in genetics

authors： Gava SG,Tavares NC,Falcone FH,Oliveira G,Mourão MM

更新日期：2019-10-18 00:00:00

abstract：OBJECTIVES:Using a novel candidate SNP approach, we aimed to identify a possible genetic basis for the higher glioma incidence in Whites relative to East Asians and African-Americans. METHODS:  We hypothesized that genetic regions containing SNPs with extreme differences in allele frequencies across ethnicities are mo...

journal_title：Frontiers in genetics

authors： Jacobs DI,Walsh KM,Wrensch M,Wiencke J,Jenkins R,Houlston RS,Bondy M,Simon M,Sanson M,Gousias K,Schramm J,Labussière M,Di Stefano AL,Wichmann HE,Müller-Nurasyid M,Schreiber S,Franke A,Moebus S,Eisele L,Dewan AT,Du

更新日期：2012-10-12 00:00:00

abstract：:During plant-pathogen interactions, pathogens secrete many rapidly evolving, small secreted proteins (SSPs) that can modify plant defense and permit pathogens to colonize plant tissue. The fungal pathogen Zymoseptoria tritici is the causal agent of Septoria tritici blotch (STB), one of the most important foliar diseas...

journal_title：Frontiers in genetics

authors： Zhou B,Benbow HR,Brennan CJ,Arunachalam C,Karki SJ,Mullins E,Feechan A,Burke JI,Doohan FM

更新日期：2020-05-12 00:00:00

abstract：:The comet assay is a simple and cost effective technique, commonly used to analyze and quantify DNA damage in individual cells. The versatility of the comet assay allows introduction of various modifications to the basic technique. The difference in the methylation sensitivity of the isoschizomeric restriction enzymes...

journal_title：Frontiers in genetics

authors： Lewies A,Van Dyk E,Wentzel JF,Pretorius PJ

更新日期：2014-07-07 00:00:00

abstract：:Our understanding of the biological role of N6-methyladenosine (m6A), a ubiquitous non-editing RNA modification, has increased greatly since 2011. More recently, work from several labs revealed that m6A methylation regulates several aspects of mRNA metabolism. The "writer" protein METTL3, known as MT-A70 in humans, Dm...

journal_title：Frontiers in genetics

authors： Rockwell AL,Hongay CF

更新日期：2019-11-12 00:00:00

abstract：:Malaria remains a major healthcare risk to growing economies like India, and a chromosome-level reference genome of Anopheles stephensi is critical for successful vector management and understanding of vector evolution using comparative genomics. We report chromosome-level assemblies of an Indian strain, STE2, and a P...

journal_title：Frontiers in genetics

authors： Chida AR,Ravi S,Jayaprasad S,Paul K,Saha J,Suresh C,Whadgar S,Kumar N,Rao K R,Ghosh C,Choudhary B,Subramani S,Srinivasan S

更新日期：2020-11-16 00:00:00

abstract：:Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in ...

journal_title：Frontiers in genetics

authors： Dai B,Wang F,Nie X,Du H,Zhao Y,Yin Z,Li H,Fan J,Wen Z,Wang DW,Chen C

更新日期：2020-11-20 00:00:00

abstract：:Disease relationship studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis, and drug development are important. Traditional approaches consider one type of disease data or aggregating multiple types of disease data into a single network, which results in important temporal- or context-re...

journal_title：Frontiers in genetics

authors： Yu L,Yao S,Gao L,Zha Y

更新日期：2019-01-18 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcinomas. At the molecular level, the EMT transition is characterized by a...

journal_title：Frontiers in genetics

authors： Kim JE,Leung E,Baguley BC,Finlay GJ

更新日期：2013-05-31 00:00:00

abstract：:Common carp is a major aquaculture species worldwide, commonly sold alive but also as processed headless carcass or filets. However, recording of processing yields is impossible on live breeding candidates, and alternatives for genetic improvement are either sib selection based on slaughtered fish, or indirect selecti...

journal_title：Frontiers in genetics

authors： Prchal M,Bugeon J,Vandeputte M,Kause A,Vergnet A,Zhao J,Gela D,Genestout L,Bestin A,Haffray P,Kocour M

更新日期：2018-07-30 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:Periconceptional folic acid use can often prevent neural tube defects (NTDs). Variants of genes involved in folate metabolism in mothers and children have been associated with occurrence of NTDs. We identified Irish families with individuals affected by neural tube defects. In these families, we observed that neural t...

journal_title：Frontiers in genetics

authors： Fisk Green R,Byrne J,Crider KS,Gallagher M,Koontz D,Berry RJ

更新日期：2013-11-06 00:00:00

abstract：:The extent to which genetic gain achieved from selection programs under strictly controlled environments in the nucleus that can be expressed in commercial production systems is not well-documented in aquaculture species. The main aim of this paper was to assess the effects of genotype by environment interaction on ge...

journal_title：Frontiers in genetics

authors： Nguyen NH,Hamzah A,Thoa NP

更新日期：2017-06-13 00:00:00

abstract：:Specialized cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation or invasion potentially affects the future health of the child a...

journal_title：Frontiers in genetics

authors： Logan PC,Mitchell MD,Lobie PE

更新日期：2013-12-04 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated with multiple distinct phenotypes. We show that pleiotropic associatio...

journal_title：Frontiers in genetics

authors： Hartley SW,Monti S,Liu CT,Steinberg MH,Sebastiani P

更新日期：2012-09-11 00:00:00

abstract：:It is critical for patients who cannot undergo eradicable surgery to predict the risk of lung cancer recurrence and metastasis; therefore, the physicians can design the appropriate adjuvant therapy plan. However, traditional circulating tumor cell (CTC) detection or next-generation sequencing (NGS)-based methods are u...

journal_title：Frontiers in genetics

authors： Wu Z,Wang L,Li C,Cai Y,Liang Y,Mo X,Lu Q,Dong L,Liu Y

更新日期：2020-08-25 00:00:00

abstract：:This study examined reasons for participation in a genetic study of risk for multiple sclerosis (MS). Our sample consisted of 101 patients diagnosed with MS who were approached about enrolling in the Multiple Sclerosis Genetic Susceptibility Study. Participants were predominantly Hispanic (80%), female (80%), and well...

journal_title：Frontiers in genetics

authors： Cuccaro ML,Manrique CP,Quintero MA,Martinez R,McCauley JL

更新日期：2020-03-13 00:00:00

abstract：:Vibrio cholerae, a gram-negative bacterium that causes cholera, has already caused seven major pandemics across the world and infects roughly 1.3-4 million people every year. Cholera treatment primarily involves oral rehydration therapy supplemented with antibiotics. But recently, multidrug-resistant strains of V. cho...

journal_title：Frontiers in genetics

authors： Shankar U,Jain N,Majee P,Kodgire P,Sharma TK,Kumar A

更新日期：2020-09-25 00:00:00

abstract：:Leprosy, an infectious disease caused by Mycobacterium leprae, affects millions of people worldwide. However, little is known regarding its molecular pathophysiological mechanisms. In this study, a comprehensive assessment of human mRNA was performed on leprosy skin lesions by using DNA chip microarrays, which include...

journal_title：Frontiers in genetics

authors： Belone Ade F,Rosa PS,Trombone AP,Fachin LR,Guidella CC,Ura S,Barreto JA,Pinilla MG,de Carvalho AF,Carraro DM,Soares FA,Soares CT

更新日期：2015-11-20 00:00:00

abstract：:We evaluated differences in gene expression in pigs from the Porcine Reproductive and Respiratory Syndrome (PRRS) Host Genetics Consortium initiative showing a range of responses to PRRS virus infection. Pigs were allocated into four phenotypic groups according to their serum viral level and weight gain. RNA obtained ...

journal_title：Frontiers in genetics

authors： Arceo ME,Ernst CW,Lunney JK,Choi I,Raney NE,Huang T,Tuggle CK,Rowland RR,Steibel JP

更新日期：2013-01-16 00:00:00