Wheat Encodes Small, Secreted Proteins That Contribute to Resistance to Septoria Tritici Blotch.

abstract：:Global microarray gene expression analyses previously demonstrated differences in female and male embryos during neurodevelopment. In particular, before sexual maturation of the gonads, the differences seem to concentrate on the expression of genes encoded on the X- and Y-chromosomes. To investigate genome-wide differ...

journal_title：Frontiers in genetics

authors： Johansson MM,Pottmeier P,Suciu P,Ahmad T,Zaghlool A,Halvardson J,Darj E,Feuk L,Peuckert C,Jazin E

更新日期：2019-09-24 00:00:00

abstract：:Background: The aim of this study was to explore the Human Papillomavirus (HPV) genotype composition and intra-genotype variants within individual samples of low- and high-grade cervical cytology by deep sequencing. Clinical, cytological, sequencing, and functional/structural data were forged into an integrated varian...

journal_title：Frontiers in genetics

authors： Shen-Gunther J,Cai H,Zhang H,Wang Y

更新日期：2019-05-24 00:00:00

abstract：:Anther extrusion (AE) is the most important male floral trait for hybrid wheat seed production. AE is a complex quantitative trait that is difficult to phenotype reliably in field experiments not only due to high genotype-by-environment effects but also due to the short expression window in the field condition. In thi...

journal_title：Frontiers in genetics

authors： Adhikari A,Basnet BR,Crossa J,Dreisigacker S,Camarillo F,Bhati PK,Jarquin D,Manes Y,Ibrahim AMH

更新日期：2020-12-08 00:00:00

abstract：:Members of the Cryptococcus complex, includes Cryptococcus neoformans (most common fungal infection of the brain) and Cryptococcus gattii (high-impact emerging pathogen worldwide). Currently, the fungal multilocus sequence typing database (Fungal MLST Database) constitutes a valuable data repository of the genes used ...

journal_title：Frontiers in genetics

authors： Muñoz M,Camargo M,Ramírez JD

更新日期：2018-04-24 00:00:00

abstract：:Vibrio cholerae, a gram-negative bacterium that causes cholera, has already caused seven major pandemics across the world and infects roughly 1.3-4 million people every year. Cholera treatment primarily involves oral rehydration therapy supplemented with antibiotics. But recently, multidrug-resistant strains of V. cho...

journal_title：Frontiers in genetics

authors： Shankar U,Jain N,Majee P,Kodgire P,Sharma TK,Kumar A

更新日期：2020-09-25 00:00:00

abstract：:ncRNAs are key genes in many human diseases including cancer and viral infection, as well as providing critical functions in pathogenic organisms such as fungi, bacteria, viruses, and protists. Until now the identification and characterization of ncRNAs associated with disease has been slow or inaccurate requiring man...

journal_title：Frontiers in genetics

authors： Collins LJ

更新日期：2011-12-27 00:00:00

abstract：:In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention. This study examined whether fat mass and obesity-associated (FTO) genes are linked, taking into account a Genome-wide Association Stu...

journal_title：Frontiers in genetics

authors： Lan N,Lu Y,Zhang Y,Pu S,Xi H,Nie X,Liu J,Yuan W

更新日期：2020-11-16 00:00:00

abstract：:Analysis of bulk RNA sequencing (RNA-Seq) data is a valuable tool to understand transcription at the genome scale. Targeted sequencing of RNA has emerged as a practical means of assessing the majority of the transcriptomic space with less reliance on large resources for consumables and bioinformatics. TempO-Seq is a t...

journal_title：Frontiers in genetics

authors： Bushel PR,Ferguson SS,Ramaiahgari SC,Paules RS,Auerbach SS

更新日期：2020-06-23 00:00:00

abstract：:Neurodegenerative diseases share pathogenic mechanisms at the cellular level including protein misfolding, excitotoxicity and altered RNA homeostasis among others. Recent advances have shown that the genetic causes underlying these pathologies overlap, hinting at the existence of a genetic network for neurodegeneratio...

journal_title：Frontiers in genetics

authors： Therrien M,Parker JA

更新日期：2014-04-17 00:00:00

abstract：:A variety of statistical methods, such as admixture models, have been used to estimate genomic breed composition (GBC). These methods, however, tend to produce non-zero components to reference breeds that shared some genomic similarity with a test animal. These non-essential GBC components, in turn, offset the estimat...

journal_title：Frontiers in genetics

authors： Wang Y,Wu XL,Li Z,Bao Z,Tait RG Jr,Bauck S,Rosa GJM

更新日期：2020-06-11 00:00:00

abstract：:Respiratory burst oxidase homologs (Rbohs) play a predominant role in reactive oxygen species (ROS) production, which is crucial in plant growth, differentiation, as well as their responses to biotic and abiotic stresses. To date, however, there is little knowledge about the function of cotton Rboh genes. Here, we ide...

journal_title：Frontiers in genetics

authors： Chang Y,Li B,Shi Q,Geng R,Geng S,Liu J,Zhang Y,Cai Y

更新日期：2020-09-11 00:00:00

abstract：:It has been shown by many researchers that SET-domain containing proteins modify chromatin structure and, as expected, genes coding for SET-domain containing proteins have been found in all eukaryotic genomes sequenced to date. However, during the last years, a great number of bacterial genomes have been sequenced and...

journal_title：Frontiers in genetics

authors： Alvarez-Venegas R

更新日期：2014-04-02 00:00:00

abstract：:Tolerance to infections is defined as the ability of a host to limit the impact of a given pathogen burden on host performance. Uncoupling resistance and tolerance is a challenge, and there is a need to be able to separate them using specific trait recording or statistical methods. We present three statistical methods...

journal_title：Frontiers in genetics

authors： Kause A,Odegård J

更新日期：2012-12-14 00:00:00

abstract：:Cell secretion is an important physiological process that ensures smooth metabolic activities and tissue repair as well as growth and immunological functions in the body. Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. The secretory materials are contained wi...

journal_title：Frontiers in genetics

authors： Ishikawa T,Toyoda Y,Yoshiura K,Niikawa N

更新日期：2013-01-02 00:00:00

abstract：:Alport syndrome (AS) is a rare and inherited renal disorder with an autosomal recessive mode of inheritance. AS patients usually manifest with hematuria and progressive renal disorder also occasionally accompanied by hearing loss and ophthalmic disease. Germline variants in collagen type IV α-4 (COL4A4) gene lead to a...

journal_title：Frontiers in genetics

authors： Zhu F,Li W,Li Z,Zhu H,Xiong J

更新日期：2019-01-28 00:00:00

abstract：:In recent years, miRNAs have been verified to play an irreplaceable role in biological processes associated with human disease. Discovering potential disease-related miRNAs helps explain the underlying pathogenesis of the disease at the molecular level. Given the high cost and labor intensity of biological experiments...

journal_title：Frontiers in genetics

authors： Xu J,Cai L,Liao B,Zhu W,Wang P,Meng Y,Lang J,Tian G,Yang J

更新日期：2019-12-11 00:00:00

abstract：:The availability of massive amounts of DNA sequence data, from 1000s of genomes even in a single project has had a huge impact on our understanding of biology, but also creates several problems for biologists carrying out those experiments. Bioinformatic analysis of sequence data is perhaps the most obvious challenge ...

journal_title：Frontiers in genetics

authors： Hadfield J,Eldridge MD

更新日期：2014-02-20 00:00:00

abstract：:Malaria remains a major healthcare risk to growing economies like India, and a chromosome-level reference genome of Anopheles stephensi is critical for successful vector management and understanding of vector evolution using comparative genomics. We report chromosome-level assemblies of an Indian strain, STE2, and a P...

journal_title：Frontiers in genetics

authors： Chida AR,Ravi S,Jayaprasad S,Paul K,Saha J,Suresh C,Whadgar S,Kumar N,Rao K R,Ghosh C,Choudhary B,Subramani S,Srinivasan S

更新日期：2020-11-16 00:00:00

abstract：:We report on three new patients with spondyloocular syndrome (SOS) in a consanguineous Pakistani family. All three patients present progressive generalized osteoporosis, short stature, recurrent fractures, hearing loss and visual impairments. WES revealed a novel homozygous frameshift variant in exon 11 of XYLT2 (NG 0...

journal_title：Frontiers in genetics

authors： Kausar M,Chew EGY,Ullah H,Anees M,Khor CC,Foo JN,Makitie O,Siddiqi S

更新日期：2019-03-05 00:00:00

abstract：:The southern muriqui (Brachyteles arachnoides) is the largest neotropical primate. This species is endemic to Brazil and is currently critically endangered due to its habitat destruction. The genetic basis underlying adaptive traits of New World monkeys has been a subject of interest to several investigators, with sig...

journal_title：Frontiers in genetics

authors： Moreira DA,Lamarca AP,Soares RF,Coelho AMA,Furtado C,Scherer NM,Moreira MAM,Seuánez HN,Boroni M

更新日期：2020-07-31 00:00:00

abstract：:The ability to sense and respond to stressful conditions is essential to maintain organismal homeostasis. It has long been recognized that stress response factors that improve survival in changing conditions can also influence longevity. In this review, we discuss different strategies used by animals in response to de...

journal_title：Frontiers in genetics

authors： Iranon NN,Miller DL

更新日期：2012-11-27 00:00:00

abstract：:Genotype imputation is a powerful tool for increasing statistical power in an association analysis. Meta-analysis of multiple study datasets also requires a substantial overlap of SNPs for a successful association analysis, which can be achieved by imputation. Quality of imputed datasets is largely dependent on the so...

journal_title：Frontiers in genetics

authors： Schurz H,Müller SJ,van Helden PD,Tromp G,Hoal EG,Kinnear CJ,Möller M

更新日期：2019-02-05 00:00:00

abstract：:Recently, an increasing number of studies sequence multiple biopsies of primary tumors, and even paired metastatic tumors to understand heterogeneity and the evolutionary trajectory of cancer progression. Although several algorithms are available to infer the phylogeny, most tools rely on accurate measurements of muta...

journal_title：Frontiers in genetics

authors： Wu P,Hou L,Zhang Y,Zhang L

更新日期：2020-02-07 00:00:00

abstract：:THE DIAGNOSIS OF A SUSPECTED TUMOR LESION FACES TWO BASIC PROBLEMS: detection and identification of the specific type of tumor. Radiological techniques are commonly used for the detection and localization of solid tumors. Prerequisite is a high intrinsic or enhanced contrast between normal and neoplastic tissue. Ident...

journal_title：Frontiers in genetics

authors： Dominietto M,Rudin M

更新日期：2014-01-13 00:00:00

abstract：:Quantitative traits are usually controlled by numerous genomic variants with small individual effects, and variances associated with those traits are explained in a continuous manner. However, the relative contributions of genomic regions to observed genetic variations have not been well explored using sequence level ...

journal_title：Frontiers in genetics

authors： Bhuiyan MSA,Lim D,Park M,Lee S,Kim Y,Gondro C,Park B,Lee S

更新日期：2018-06-22 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that play key regulatory roles in cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in improving cancer prognostic, predictive, diagnostic and therapeutic approaches, they have become an area of intense research focus in recent yea...

journal_title：Frontiers in genetics

authors： Macharia LW,Wanjiru CM,Mureithi MW,Pereira CM,Ferrer VP,Moura-Neto V

更新日期：2019-02-20 00:00:00

abstract：:Background: Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond tacrolimus dose requirements remains controversial. Methods: In a cohort of 121 kidney transplant recipients, we analyzed the CYP3A4*1B, CYP3A4*22, and CYP3A5*3 allele...

journal_title：Frontiers in genetics

authors： Abdel-Kahaar E,Winter S,Tremmel R,Schaeffeler E,Olbricht CJ,Wieland E,Schwab M,Shipkova M,Jaeger SU

更新日期：2019-09-26 00:00:00

abstract：:While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of clustered regularly interspaced short palindromic repeat (CRISPR)-based gene editing has provided exciting new opportunities for genetics-based strategies to control these diseases. In ...

journal_title：Frontiers in genetics

authors： Marshall JM,Raban RR,Kandul NP,Edula JR,León TM,Akbari OS

更新日期：2019-10-30 00:00:00

abstract：:RNA-binding proteins (RBPs) interacting with target RNAs play essential roles in RNA metabolism at the post-transcription level. Perturbations of RBPs can accelerate cancer development and cause dysregulation of the immune cell function and activity leading to evade immune destruction of cancer cells. However, few stu...

journal_title：Frontiers in genetics

authors： Hu G,Jiang Q,Liu L,Peng H,Wang Y,Li S,Tang Y,Yu J,Yang J,Liu Z

更新日期：2021-01-11 00:00:00

abstract：:Mesopelagic fish are largely abundant poorly studied fish that are still intact, but which, due to their potentially great added value, will be imminently exploited by humans. Therefore, studies that provide information to anticipate the anthropogenic impact on this important resource are urgently needed. In particula...

journal_title：Frontiers in genetics

authors： Rodriguez-Ezpeleta N,Álvarez P,Irigoien X

更新日期：2017-11-28 00:00:00