Abstract:
INTRODUCTION:Chronic rhinosinusitis with nasal polyps is a multifactorial disease entity with an unclear pathogenesis. Contradictory data exist in the literature on the potential implication of viral elements in adult patients with chronic rhinosinusitis. OBJECTIVE:To compare the prevalence of human herpes viruses (1-6) and Human Papilloma Virus in adult patients with chronic rhinosinusitis with nasal polyps and healthy controls. METHODS:Viral DNA presence was evaluated by real-time polymerase chain reaction application to nasal polyps specimens from 91 chronic rhinosinusitis with nasal polyps patients and nasal turbinate mucosa from 38 healthy controls. RESULTS:Epstein-Barr virus positivity was higher in nasal polyps (24/91; 26.4%) versus controls (4/38; 10.5%), but the difference did not reach significance (p=0.06). Human herpes virus-6 positivity was lower in nasal polyps (13/91; 14.29%) versus controls (10/38; 26.32%, p=0.13). In chronic rhinosinusitis with nasal polyps group, 1 sample was herpes simplex virus-1-positive (1/91; 1.1%), and another was cytomegalovirus-positive (1/91; 1.1%), versus none in controls. No sample was positive for herpes simplex virus-2, varicella-zoster virus, high-risk-human papilloma viruses (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) and low-risk-human papilloma viruses (6, 11). CONCLUSION:Differences in Epstein-Barr virus and human herpes virus-6 positivity among patients with chronic rhinosinusitis with nasal polyps and healthy controls are not statistically significant, weakening the likelihood of their implication in chronic rhinosinusitis with nasal polyps pathogenesis.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Ioannidis D,Lachanas VA,Florou Z,Bizakis JG,Petinaki E,Skoulakis CEdoi
10.1016/j.bjorl.2015.08.010subject
Has Abstractpub_date
2015-11-01 00:00:00pages
658-62issue
6eissn
1808-8694issn
1808-8686pii
S1808-8694(15)00149-4journal_volume
81pub_type
杂志文章abstract:INTRODUCTION:Abused children and adolescents are exposed to factors that can trigger vocal changes. OBJECTIVE:This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communicati...
journal_title:Brazilian journal of otorhinolaryngology
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journal_title:Brazilian journal of otorhinolaryngology
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journal_title:Brazilian journal of otorhinolaryngology
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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