Abstract:
OBJECTIVE:We tested for association of the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. METHODS:A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. RESULTS:In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ(2)=4.21, p=0.040). CONCLUSION:These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Park S,Park JE,Yoo HJ,Kim JW,Cheong JH,Han DH,Kim Y,Kim BNdoi
10.4306/pi.2015.12.4.563subject
Has Abstractpub_date
2015-10-01 00:00:00pages
563-5issue
4eissn
1738-3684issn
1976-3026journal_volume
12pub_type
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