Current Status of Epigenetics and Anticancer Drug Discovery.

abstract：BACKGROUND:Glutathione (GSH), which is the predominant low molecular weight intracellular thiol in mammals, has multiple functions, such as those of protecting against oxidative stress and detoxifying endogenous and exogenous electrophiles. High GSH levels, which have been observed in various types of tumors, have been...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cilurzo F,Cristiano MC,Da Pian M,Cianflone E,Quintieri L,Paolino D,Pasut G

更新日期：2019-01-01 00:00:00

abstract：:For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial he...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ferreira IC,Vaz JA,Vasconcelos MH,Martins A

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:One of the major goals of computational chemists is to determine and develop the pathways for anticancer drug discovery and development. In recent past, high performance computing systems elicited the desired results with little or no side effects. The aim of the current review is to evaluate the role of com...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hameed R,Khan A,Khan S,Perveen S

更新日期：2019-01-01 00:00:00

abstract：:Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the grow...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rengasamy P

更新日期：2017-01-01 00:00:00

abstract：:The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhang Y,Xu W

更新日期：2008-08-01 00:00:00

abstract：:The importance of monoclonal antibodies in oncology has increased drastically following the discovery of Milstein and Kohler. Since the first approval of the monoclonal antibody, i.e. Rituximab in 1997 by the FDA, there was a decline in further applications but this number has significantly increased over the last thr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kaur N,Goyal A,Sindhu RK

更新日期：2020-01-01 00:00:00

abstract：:Backgroun/Methods: In attempt to develop new potent anti-tumor agents, a series of quinoxaline derivatives was designed and synthesized. The novel compounds were tested in vitro for their anti-proliferative activities against HePG-2, MCF-7 and HCT-116 cell lines. Additionally, DNA binding affinities as well as DNA-top...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Eissa IH,El-Naggar AM,El-Sattar NEAA,Youssef ASA

更新日期：2018-01-01 00:00:00

abstract：:Cancer is one of the most fatal diseases in the world and it has been years that finding new drugs and chemotherapeutic techniques with lowest side effects become one of the most important challenging matters needs really hard efforts. Chlorambucil (CBL), an ancient direct-acting alkylating anticancer agent, is common...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tabasi MA,Amanlou M,Siadat SD,Nourmohammadi Z,Omoomi FD,Ebrahimi SE,Aghasadeghi MR,Rahimi P,Pourhosseini S,Mehravi B,Ardestani MS

更新日期：2013-11-01 00:00:00

abstract：:Urothelial cell carcinoma is one of the most common malignancies of the urinary tract. The standard of care, intravesical chemo- and immunotherapy, while effective, is associated with a considerable side-effect profile and approximately 30% of patients either fail to respond to treatment or suffer recurrent disease wi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carradori S,Cristini C,Secci D,Gulia C,Gentile V,Di Pierro GB

更新日期：2012-07-01 00:00:00

abstract：:Protein kinases are one of the largest known families of enzyme characterized by having a well conserved ATP binding pocket. Most of the synthetic kinase inhibitors are ATP-competitive, but display some potential problems, like selectivity, discrepancy between the in vitro and in vivo inhibition assays and an high ris...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cozza G,Bortolato A,Menta E,Cavalletti E,Spinelli S,Moro S

更新日期：2009-09-01 00:00:00

abstract：:Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to induce cell death specifically in malign...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Chakraborty P,Roy SS,Bhattacharya S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Pyrazole derivatives have been reported as both anticancer and antiinflammatory agents. OBJECTIVE:This study was conducted to develop new pyrazole derivatives as potential anticancer and/or antiinflammatory agents. Their molecular mechanisms of action have been investigated. METHOD:a series of new triarylp...

journal_title：Anti-cancer agents in medicinal chemistry

authors： El-Gamal MI,Abdel-Maksoud MS,Gamal El-Din MM,Shin JS,Lee KT,Yoo KH,Oh CH

更新日期：2017-01-01 00:00:00

abstract：:This review summarizes the reported molecular mechanisms underlying the antileukemic property of Sesquiterpene Lactones (SLs). This systematic review was registered in the PROSPERO database and conducted following the PRISMA Statements. The MeSH terms, Sesquiterpenes, Lactones and Leukemia were used in four databases ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： da Silva Castro E,Alves Antunes LA,Revoredo Lobo JF,Ratcliffe NA,Borges RM,Rocha L,Burth P,Fonte Amorim LM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Despite a number of measures having been taken for cancer management, it is still the second leading cause of death worldwide. p53 is the protein principally being targeted for cancer treatment. Targeting p53 localization may be an effective strategy in chemotherapy as it controls major cell death pathways b...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kamil M,Haque E,Mir SS,Irfan S,Hasan A,Sheikh S,Alam S,Ansari KM,Nazir A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The present study was carried out to evaluate the anticancer property of an alkylamino phenol derivative -2-((3,4-Dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol) (THTMP) against human breast cancer cells. The cytotoxicity of the THTMP was assessed to know its specificity towards breast cancer ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Palanivel S,Yli-Harja O,Kandhavelu M

更新日期：2020-01-01 00:00:00

abstract：:Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compou...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Fuzer AM,Filho JC,Becceneri AB,Dos Santos DA,da Silva MF,Vieira PC,Fernandes JB,Selistre-de-Araujo HS,Cazal CM,Cominetti MR

更新日期：2013-12-01 00:00:00

abstract：:In attempts to overcome the drawbacks of cisplatin - severe toxicity, drug resistance and poor oral bioavailability - the development of platinum-based drugs has progressed from carboplatin and oxaliplatin to the newest generation of drugs, such as satraplatin, picoplatin and the multinuclear platinum complex BBR3464 ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Olszewski U,Hamilton G

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：:Compounds that can bind and stabilize non-canonical DNA structures are named quadruplex and are of interest in anticancer drug design due to their selective inhibitions of telomerase and consequent effects on cell proliferation. In this study, we report novel Co/Cu [II] complex compounds as G-quadruplex DNA binding li...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Saour K,Lafta D

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are emerging as important regulators in various pathobiological processes in cancer. Genistein, as a major isoflavonoid isolated from dietary soybean, possesses a wide variety of biological activities particularly in cancer prevention. However, the molecular mechanisms by which genistein elicits its...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xu L,Xiang J,Shen J,Zou X,Zhai S,Yin Y,Li P,Wang X,Sun Q

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Intrinsic resistance to apoptotic cell death due to co-occurrence of mutated KRAS and p53 is frequently reported in pancreatic cancer that renders them aggressive, highly proliferative and metastatic. In addition, these cancer types are less sensitive to apoptosis inducing drugs where promotion of autophagic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pal S,Salunke-Gawalib S,Konkimallaa VB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Cinnamic acid (CA), also known as 3-phenyl-2-propenoic acid, is a naturally occurring aromatic fatty acid found commonly in cinnamon, grapes, tea, cocoa, spinach and celery. Various studies have identified CA to have anti-proliferative action on glioblastoma, melanoma, prostate and lung carcinoma cells. OBJ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pal A,Tapadar P,Pal R

更新日期：2020-08-07 00:00:00

abstract：:As cancers are one of the most important causes of human morbidity and mortality worldwide, researchers try to discover novel compounds and therapeutic approaches to decrease survival of cancer cells, angiogenesis, proliferation and metastasis. In the last decade, use of special phytochemical compounds and flavonoids ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hosseinzadeh E,Hassanzadeh A,Marofi F,Alivand MR,Solali S

更新日期：2020-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and non-surgical ones, cannot effectively cure this disease. Increasing evidence has revealed the importance of cancer stem cells (CSCs) in hepatocarcinogenesis, an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Lau CK,Yang ZF,Fan ST

更新日期：2011-07-01 00:00:00

abstract：:Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due t...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cerella C,Dicato M,Jacob C,Diederich M

更新日期：2011-03-01 00:00:00

abstract：:Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least investigated families. In the review, we have provided a comprehensive listing of 133 of these compounds for which anti-tumor activity has been documented within the literature. We have compiled and studied their chemical structur...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mangal M,Khan MI,Agarwal SM

更新日期：2015-01-01 00:00:00

abstract：:Indole compounds, found in cruciferous vegetables, are potent anti-cancer agents. Studies with indole-3-carbinol (I3C) and its dimeric product, 3,3'-diindolylmethane (DIM) suggest that these compounds have the ability to deregulate multiple cellular signaling pathways, including PI3K/Akt/mTOR signaling pathway. These ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ahmad A,Biersack B,Li Y,Kong D,Bao B,Schobert R,Padhye SB,Sarkar FH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Tumor recurrence and metastasis are still leading causes of cancer mortality worldwide. The influence of traditional treatment strategies against metastatic tumors may still be limited. To search for novel and powerful agents against tumors has become a major research focus. In this study, Artemisinin (ARM),...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Li Y,Zhou X,Liu J,Yuan X,He Q

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. OBJECTIVE:The present study ai...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rizzk YW,El-Deen IM,Mohammed FZ,Abdelhamid MS,Khedr AIM

更新日期：2019-01-01 00:00:00

abstract：:In the early 1960s, inorganic pyrophosphate (PPi) was found to be present in body fluids and to act as a natural inhibitor of calcification by its interaction with hydroxyapatite. In addition to inhibiting the formation of calcium phosphate, PPi also inhibited dissolution of hydroxyapatite crystals, which made it inte...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Widler L,Jahnke W,Green JR

更新日期：2012-02-01 00:00:00