Comparison of the effects of recently developed alpha 2-adrenergic antagonists with yohimbine and rauwolscine on monoamine synthesis in rat brain.

abstract：:The characteristics of the uptake of acetaminophen (N-acetyl-p-aminophenol or paracetamol, APAP) in incubations of isolated rat liver cells were consistent with diffusion of the drug being the predominant mechanism of APAP influx in these cells at concentrations above 0.5 mM. At lower substrate concentrations (below 0...

journal_title：Biochemical pharmacology

authors： McPhail ME,Knowles RG,Salter M,Dawson J,Burchell B,Pogson CI

更新日期：1993-04-22 00:00:00

abstract：:The 3'-fluoro-and 3'-azido-substituted derivatives of 2',3'-dideoxythymidine (ddThd), 2',3'-dideoxyuridine (ddUrd), 2',3'-dideoxy-5-ethyluridine (ddEtUrd) and 2',3'-dideoxycytidine (ddCyd) have been synthesized and evaluated for their anti-retrovirus activity [against human immunodeficiency virus (HIV) and murine Molo...

journal_title：Biochemical pharmacology

authors： Balzarini J,Baba M,Pauwels R,Herdewijn P,De Clerq E

更新日期：1988-07-15 00:00:00

abstract：:The ability of gold coordination complexes to bind to DNA and produce inter-strand cross-links in DNA was assessed in an assay system based on the fluorescence properties of the DNA intercalative dye, ethidium bromide. Results from these studies using a variety of gold(I) and gold(III) complexes suggest that the abili...

journal_title：Biochemical pharmacology

authors： Mirabelli CK,Zimmerman JP,Bartus HR,Sung CM,Crooke ST

更新日期：1986-05-01 00:00:00

abstract：:The antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has been shown previously to be enhanced markedly by the co-administration of pyrimidine deoxyribonucleosides (Lin and Prusoff, Cancer Res 47: 394-397, 1987). In the present study, we examined the cellular mechanisms underlying the augmentation effe...

journal_title：Biochemical pharmacology

authors： Poo WJ,Guo X,Haslund B,Mozdziesz DE

更新日期：1997-03-07 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays an important role in the cardiovascular system. However, the potential protective role of inhibitor 1 of protein phosphatase 1 (I1PP1), which is able to regulate CaMKII, in high glucose-induced cardiomyocytes injury remains unknown. In the present study, cardi...

journal_title：Biochemical pharmacology

authors： Sun L,Chen Y,Luo H,Xu M,Meng G,Zhang W

更新日期：2019-05-01 00:00:00

abstract：:Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, u...

journal_title：Biochemical pharmacology

authors： Cotariu D,Evans S,Lahat E,Theitler J,Bistritzer T,Zaidman JL

更新日期：1992-02-04 00:00:00

abstract：:Agonist binding properties of rat striatal D-2 dopamine (DA) receptors were investigated after in vivo or in vitro estradiol or progesterone exposures in order to elucidate the mechanism of action of steroid hormones on DA receptors. Chronic estradiol treatment of ovariectomized rats (10 micrograms, twice each day, fo...

journal_title：Biochemical pharmacology

authors： Lévesque D,Di Paolo T

更新日期：1993-02-09 00:00:00

abstract：:The p53 tumor suppressor protein provides a major anti-cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in human cancer. Recent work has led to the realization that p53 lies at the hub of a very complex network of signaling pathways, which integ...

journal_title：Biochemical pharmacology

authors： Oren M,Damalas A,Gottlieb T,Michael D,Taplick J,Leal JF,Maya R,Moas M,Seger R,Taya Y,Ben-Ze'ev A

更新日期：2002-09-01 00:00:00

abstract：:To investigate the hypothesis that cyclic AMP (cAMP) regulates arachidonic acid metabolism in vascular tissue, we have studied the effects of forskolin (FSK), an activator of adenylate cyclase, and 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, on hormone-stimulated prostacyclin (PGI2) synthesis in...

journal_title：Biochemical pharmacology

authors： Whorton AR,Collawn JB,Montgomery ME,Young SL,Kent RS

更新日期：1985-01-01 00:00:00

abstract：:The effect of biscoclaurine (bisbenzylisoquinoline) alkaloids on phospholipase A2 and C activation in signal transduction system of rabbit platelet was studied. Isotetrandrine, cepharanthine and berbamine inhibited the aggregation induced by collagen but not by other stimuli such as thrombin and arachidonic acid, whil...

journal_title：Biochemical pharmacology

authors： Hashizume T,Yamaguchi H,Sato T,Fujii T

更新日期：1991-02-01 00:00:00

abstract：:Programmed cell death (PCD) is a physiological process occurring during development and in pathological conditions of animals and plants. The cell death program can be subdivided into three functionally different phases: a stimulus-dependent induction phase, an effector phase during which the wide range of death-stimu...

journal_title：Biochemical pharmacology

authors： Jabs T

更新日期：1999-02-01 00:00:00

abstract：:Curcumin (diferuloylmethane) is a well-known agent with anti-inflammatory, antioxidant, and anticarcinogenic properties. In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK. Our in vitro kinase experime...

journal_title：Biochemical pharmacology

authors： Leu TH,Su SL,Chuang YC,Maa MC

更新日期：2003-12-15 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop family of neurotransmitter-gated ion channels, a family that also includes receptors for gamma-aminobutyric acid, glycine and 5-hydroxytryptamine. In humans, nAChRs have been implicated in several neurological and psychiatric disorders and are majo...

journal_title：Biochemical pharmacology

authors： Millar NS

更新日期：2009-10-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) plays some pivotal roles in innate immunity and inflammation. Ursolic acid (UA), an anti-inflammatory triterpene carboxylic acid, was recently reported to induce the release of pro-inflammatory mediators in resting macrophages (Mvarphi). We investigated the effects of UA on...

journal_title：Biochemical pharmacology

authors： Ikeda Y,Murakami A,Ohigashi H

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:Rho-Associated kinases ROCK1 and ROCK2 have been extensively investigated in the pathogenesis of cardiovascular disease. However, their roles are not fully understood in carcinogenesis. In this study, we investigated whether ROCK1 or ROCK2 is required for the survival and growth of hepatocellular carcinoma (...

journal_title：Biochemical pharmacology

authors： Wu H,Chen Y,Li B,Li C,Guo J,You J,Hu X,Kuang D,Qi S,Liu P,Li L,Xu C

更新日期：2020-12-02 00:00:00

abstract：:The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction...

journal_title：Biochemical pharmacology

authors： Rogers KE,Tökés ZA

更新日期：1984-02-15 00:00:00

abstract：:Reactive oxygen species (ROS) attack guanine bases in DNA and form 8-hydroxydeoxyguanosine (8-OHdG), which has been regarded simply as an oxidative mutagenic by-product. On the other hand, our previous report showed paradoxically ROS attenuating action of generated 8-OHdG. In the current study, both in vitro and in vi...

journal_title：Biochemical pharmacology

authors： Ock CY,Hong KS,Choi KS,Chung MH,Kim Ys,Kim JH,Hahm KB

更新日期：2011-01-01 00:00:00

abstract：:The in vitro metabolic ketone reduction of warfarin and its 4'-analogues acenocoumarol (4'-nitrowarfarin) and 4'-chlorowarfarin has been investigated using microsomal and cytosolic fractions of several species. Both subcellular fractions showed ketone reductase activity. The cytosolic fractions, in most species, exhib...

journal_title：Biochemical pharmacology

authors： Hermans JJ,Thijssen HH

更新日期：1989-10-01 00:00:00

abstract：:Epidemiological and experimental animal data indicate that exposure to both metals and metalloid species exacerbates the risk of human diseases, particularly cancers. Vascular endothelial growth factor (VEGF), which performs a primary function in both tumor progression and angiogenesis, is up-regulated due to exposure...

journal_title：Biochemical pharmacology

authors： Lee M,Hwang JT,Yun H,Kim EJ,Kim MJ,Kim SS,Ha J

更新日期：2006-06-28 00:00:00

abstract：:The formation, retention and biological activity of the polyglutamate metabolites of the thymidylate synthase (TS) inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) has been investigated in L1210 murine leukaemia cells grown in vitro. CB3717 polyglutamates were measured by HPLC using high specific activity 3H-CB3...

journal_title：Biochemical pharmacology

authors： Sikora E,Jackman AL,Newell DR,Calvert AH

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:The evolution of the "cholinergic anti-inflammatory pathway" and the fact that the α 7 subunit of the nicotinic acetylcholine receptor (α7nAChR) is present in the spleen, joint and on the surface of lymphocytes, opened up the prospective in this study of targeting the α7nAChR by the anticholinesterase and cho...

journal_title：Biochemical pharmacology

authors： Gowayed MA,Rothe K,Rossol M,Attia AS,Wagner U,Baerwald C,El-Abhar HS,Refaat R

更新日期：2019-12-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors are expressed on a variety of cells in the nervous system where they play key roles in synaptic transmission and information transfer. Little is known, however, about the molecular mechanisms that control their expression, distribution, and function during nervous system deve...

journal_title：Biochemical pharmacology

authors： Halvorsen SW,Jiang N,Malek R

更新日期：1995-11-09 00:00:00

abstract：:The aim of the present study was to investigate the effects of myricitrin, a flavonoid with anti-inflammatory and antinociceptive action, upon persistent neuropathic and inflammatory pain. The neuropathic pain was caused by a partial ligation (2/3) of the sciatic nerve and the inflammatory pain was induced by an intra...

journal_title：Biochemical pharmacology

authors： Meotti FC,Missau FC,Ferreira J,Pizzolatti MG,Mizuzaki C,Nogueira CW,Santos AR

更新日期：2006-12-15 00:00:00

abstract：:Staurosporine is one of the most potent and well known inhibitors of protein kinases, and it is often used to study the involvement of protein kinases in signal transduction pathways. We now report that staurosporine can induce the production of hepatocyte growth factor (HGF) independently of protein kinase inhibition...

journal_title：Biochemical pharmacology

authors： Yagi Y,Sotani T,Nagao T,Horio T,Yamamoto I,Gohda E

更新日期：2003-11-01 00:00:00

abstract：:Acute administration of alpha-naphthylisothiocyanate (ANIT) to rats has been used as a model of intrahepatic cholestasis. The mechanism of toxicity of ANIT is unknown, although recent evidence suggests a causal or permissive role for glutathione (GSH) (Dahm LJ and Roth RA, Biochem Pharmacol 42: 1181-1188, 1991). In th...

journal_title：Biochemical pharmacology

authors： Dahm LJ,Bailie MB,Roth RA

更新日期：1991-08-22 00:00:00

abstract：:Castanospermine (CS) is a potent but non-selective inhibitor of many glycohydrolases including the intestinal disaccharidases. Several CS-glucosides were synthesized to investigate the effect of an attached glucopyranosyl residue on the potency and selectivity of CS toward inhibition of intestinal disaccharidases. 8 a...

journal_title：Biochemical pharmacology

authors： Rhinehart BL,Robinson KM,King CH,Liu PS

更新日期：1990-05-15 00:00:00

abstract：:We have reported that in renal epithelial A6 cells flavones stimulate the transepithelial Cl- secretion by activating the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and/or the Na+/K+/2Cl- cotransporter. On the other hand, it has been established that cAMP activates the CFTR Cl- channel and ...

journal_title：Biochemical pharmacology

authors： Niisato N,Nishino H,Nishio K,Marunaka Y

更新日期：2004-02-15 00:00:00

abstract：:The effect of specifically derivatized dextrans, with or without antiproliferative activity on smooth muscle cells (SMC), was investigated on type I and type III collagen biosynthesis and mRNA levels in post-confluent SMC cultures. Our results indicate that dextran derivatives decreased total protein and collagen synt...

journal_title：Biochemical pharmacology

authors： Benazzoug Y,Logeart D,Labat-Robert J,Robert L,Jozefonvicz J,Kern P

更新日期：1995-03-15 00:00:00

abstract：:The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-inflammatory drugs is uncertain. Here we show that ibuprofen induces death of Walker 256 tumor cells independently on mitochondrial depolarization as estimated by flow cytometry using DioC(6)(3). Oligomycin increased mit...

journal_title：Biochemical pharmacology

authors： Campos CB,Degasperi GR,Pacífico DS,Alberici LC,Carreira RS,Guimarães F,Castilho RF,Vercesi AE

更新日期：2004-12-01 00:00:00

abstract：:The genus Mycobacterium includes non-pathogenic species such as M. smegmatis, and pathogenic species such as M. tuberculosis, the causative agent of tuberculosis (TB). Treatment of TB requires a lengthy regimen of several antibiotics, whose effectiveness has been compromised by the emergence of resistant strains. New ...

journal_title：Biochemical pharmacology

authors： Lee Y,Mootien S,Shoen C,Destefano M,Cirillo P,Asojo OA,Yeung KR,Ledizet M,Cynamon MH,Aristoff PA,Koski RA,Kaplan PA,Anthony KG

更新日期：2013-07-15 00:00:00