Abstract:
:Mechanotransduction, the mechanism by which mechanical perturbation influences genetic expression and cellular behavior, is an area of molecular biology undergoing rapid exploration and discovery. Cells are sensitive to forces such as shear, tension, and compression, and they respond accordingly through cellular proliferation, migration, tissue repair, altered metabolism, and even stem cell differentiation and maturation. The study of how cells sense and respond to mechanical stimulation is under robust expansion, with new scientific methods and technologies at our disposal. The application of these technologies to physical therapist practice may hold answers to some of our age-old questions while creating new avenues for our profession to optimize movement for societal health. Embracing this science as foundational to our profession will allow us to be valuable scientific collaborators with distinctive knowledge of the effects of loading. These partnerships will be key to augmenting the clinical utility of emerging therapies such as regenerative medicine, tissue engineering, and gene therapy. Collaboration with other scientific disciplines in these endeavors, along with the inclusion and application of these discoveries in our academic programs, will enhance the understanding of the impact of our practice on biologic and genetic processes. A basic understanding of mechanotransduction and its relevance to physical therapist practice is warranted to begin the conversation.
journal_name
Phys Therjournal_title
Physical therapyauthors
Dunn SL,Olmedo MLdoi
10.2522/ptj.20150073subject
Has Abstractpub_date
2016-05-01 00:00:00pages
712-21issue
5eissn
0031-9023issn
1538-6724pii
ptj.20150073journal_volume
96pub_type
杂志文章相关文献
PHYSICAL THERAPY文献大全abstract::Physical therapists are becoming involved increasingly in malpractice actions. The number of such actions will likely increase as the profession moves towards specialized practice and practice without medical referral. This article is intended to clarify some of the major principles of negligence and malpractice law a...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/62.5.604
更新日期:1982-05-01 00:00:00
abstract::Quadriceps femoris muscle torque was measured in 40 subjects during transcutaneous neuromuscular electrical stimulation (NMES). Three different electrode types (carbonized rubber, sponge, and adhesive) were used on each subject, permitting determination of the factors that influenced the magnitude of quadriceps femori...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/71.10.715
更新日期:1991-10-01 00:00:00
abstract::During the past two decades investigators have shown that muscle fiber is highly mutable. A variety of stimuli ranging from patterns of use to the nutritional state of the organism may lead to alterations in fiber structure and function. The purpose of this review is to provide the information necessary to understand ...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/62.12.1773
更新日期:1982-12-01 00:00:00
abstract::Chronic lung disease is a major health problem among children. Estimates suggest that one child in six has a chronic respiratory condition. This article reviews three common chronic respiratory conditions occurring in childhood for which physical therapy is usually recommended. The cause, pathophysiology, and medical ...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/61.12.1774
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to investigate the relationship between clinically accessible functional balance tools and sophisticated force platform measures in a standing position. SUBJECTS:Twenty persons who had hemiparesis secondary to a stroke and were ambulatory (mean age = 57.9 years, SD ...
journal_title:Physical therapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ptj/77.10.1052
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The optimal adjunctive therapy for wounds that fail to heal despite conventional wound care has not been established. Clinical evidence suggests improved healing in wounds treated with noncontact ultrasound therapy (NCUT). Although existing evidence supports the use of NCUT for enhanced wound hea...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.2522/ptj.20080009
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The sensitivity to change and the responsiveness of the Global Physiotherapy Examination (GPE-52) were examined in patients with localized and widespread long-lasting musculoskeletal pain. SUBJECTS:All included patients were on sick leave and constituted the treatment group in a randomized contr...
journal_title:Physical therapy
pub_type: 杂志文章
doi:
更新日期:2005-08-01 00:00:00
abstract::A posturally induced "stretch weakness" of the right hip abductor muscles has been reported in many healthy right-handed persons in the literature. The purpose of this study was to test for differences in the maximal isometric hip abduction torque produced between hip sides across multiple hip abduction angles. The to...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/68.4.496
更新日期:1988-04-01 00:00:00
abstract::Physical therapy students in baccalaureate-degree programs used a forced-choice Q sort of 49 characteristics of physical therapists to describe their concepts of a physical therapy role model at the beginning and again at the end of basic professional training. In ranking the items with the 10 highest mean values (mos...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/60.2.188
更新日期:1980-02-01 00:00:00
abstract::The changes in circulatory system behavior occurring in response to exercise stress are integrated by the central neural circulatory control system working in cooperation with local regulatory mechanisms. The regulatory events occurring during exercise may be analyzed using a closed-loop regulatory system model of the...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/61.10.1411
更新日期:1981-10-01 00:00:00
abstract::This case report describes the use of electrical stimulation with high voltage pulsed monophasic current for treatment of a large, infected wound of the thoracic spine, following a surgical debridement procedure. The patient was a 21-year-old man with spastic quadriplegic cerebral palsy who was dependent for all self-...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/73.6.355
更新日期:1993-06-01 00:00:00
abstract::We investigated the current status of the education of physical therapy students regarding elderly individuals. Data were collected through a questionnaire mailed to the directors of 101 accredited physical therapy education programs; the rate of return was 79%. Nearly all of the program directors (96%) affirmed a nee...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/67.2.234
更新日期:1987-02-01 00:00:00
abstract:Background:The impact of physical therapy on the outcomes of patients with acute low back pain (LBP) stratified by the STart Back Screening Tool (SBST) is unclear. Objective:The purpose of this study was to compare the outcomes of patients with acute LBP who were stratified as medium or high risk. Design:This was a s...
journal_title:Physical therapy
pub_type: 杂志文章,随机对照试验
doi:10.2522/ptj.20160298
更新日期:2017-03-01 00:00:00
abstract::Problem-oriented style progress notes were implemented in a skilled nursing facility where problem-oriented medical records were not in use. The problem-oriented note consists of subjective information, objective information, analysis or assessment of the problems, and plan for treatment, and is called a SOAP note. Si...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/59.2.160
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Limited research exists on the utilization and payments of physical rehabilitation services, especially among individuals with commercial insurance. OBJECTIVE:This study aimed to characterize the utilization and payments of office-based physical rehabilitation services among nonelderly individuals with comm...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.2522/ptj.20150060
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The interpretation of the results of previous anti-osteoporosis interventions after spinal cord injury (SCI) is undermined by incomplete information about the intervention dose or patient adherence to dose requirements. Rehabilitation research as a whole traditionally has struggled with these sam...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.2522/ptj.20070224
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purposes of this article are to describe the process of developing the physical therapist (PT) and physical therapist assistant (PTA) Clinical Performance Instruments (CPIs) and to present the available information on the psychometric properties of each instrument. SUBJECTS:Two hundred seven...
journal_title:Physical therapy
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tuberculous arthritis is not commonly seen by physical therapists in the United States. The purpose of this case report is to describe a case of tuberculous arthritis of the elbow. CASE DESCRIPTION:The patient was a 36-year-old man referred for physical therapy evaluation and intervention for ch...
journal_title:Physical therapy
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Following a discussion of the motor deficits commonly associated with Down's syndrome, a transdisciplinary developmental therapy model is proposed for use with infants with Down's syndrome. The model includes components from various existing intervention programs for infants as well as some current therapeutic appraoc...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/60.4.420
更新日期:1980-04-01 00:00:00
abstract::The nature of repetition and its contribution to the acquisition of motor skills in neurologically healthy subjects are examined in this article. We argue that cognitive processing is a key component of practice, which is undermined by repetitive performances. The effects on motor learning of contextual interference, ...
journal_title:Physical therapy
pub_type: 杂志文章,评审
doi:10.1093/ptj/71.2.150
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to establish the relationship between isometric muscle force and temporal-spatial gait characteristics for individuals who have had a below-knee amputation secondary to vascular disease. SUBJECTS:Twenty-two individuals (15 male, 7 female) with dysvascular below-knee...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/76.4.369
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Manual lifting is a frequent cause of back injury, and there is no evidence as to which training mode can provide the best training effect for lifting performance and muscle force. The purpose of this study was to examine the effects of a squat lift training and a free weight muscle training prog...
journal_title:Physical therapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Although studies have established the safety and feasibility of physical therapy in the critical care setting, minimal information about physical therapist practice in the neurological intensive care unit (NICU) is available. OBJECTIVE:This study describes physical therapists' treatment of people admitted t...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.2522/ptj.20140112
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to describe the relationships among measurements of torque produced during selected maximal voluntary contractions of the quadriceps femoris muscles. SUBJECTS:Twenty nondisabled women, ranging in age from 21 to 33 years (X = 25, SD = 3.5), volunteered to participate...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/74.7.674
更新日期:1994-07-01 00:00:00
abstract:Background:The prevalence of adults with Alzheimer disease (AD) aged >65 years is increasing and estimated to quadruple by 2051. Purpose:The aim of this study was to investigate postural stability in people with mild to moderate AD and factors contributing to postural instability compared with healthy peers (controls)...
journal_title:Physical therapy
pub_type: 杂志文章,评审
doi:10.2522/ptj.20160115
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:People with stroke are not meeting recommended levels of physical activity. The modifiable factors associated with poststroke physical activity levels need to be identified to develop targeted interventions. OBJECTIVE:The objective of this study was to investigate the factors at discharge from inpatient reh...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.1093/ptj/pzaa022
更新日期:2020-05-18 00:00:00
abstract:BACKGROUND:Functional impairment is common in people with chronic liver disease (CLD), and improvement is expected following liver transplantation (LT). The Six-Minute Walk Test (6MWT) is an objective measure of functional performance. OBJECTIVE:The aims of this study were: (1) to evaluate the feasibility of 6MWT perf...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.2522/ptj.20150376
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to determine the efficacy of a reimbursable, outpatient modified constraint-induced therapy (mCIT) protocol administered to subjects with chronic stroke who initially exhibited minimal movement ability in their affected wrists and fingers. SUBJECTS:The subjects were...
journal_title:Physical therapy
pub_type: 临床试验,杂志文章
doi:10.2522/ptj.20060202
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:The modified Dynamic Gait Index (mDGI) measures the capacity to adapt gait to complex tasks utilizing 8 tasks and 3 facets of performance. The measurement stability of the mDGI in specific diagnostic groups is unknown. OBJECTIVE:This study examined the psychometric properties of the mDGI in 5 diagnostic gro...
journal_title:Physical therapy
pub_type: 杂志文章
doi:10.2522/ptj.20130294
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:The study aimed to evaluate whether high-flow oxygen therapy (HFOT) during training was more effective than oxygen in improving exercise capacity in hypoxemic chronic obstructive pulmonary disease (COPD). METHODS:A total of 171 patients with COPD and chronic hypoxemia were consecutively recruited in 8 rehabi...
journal_title:Physical therapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/ptj/pzaa076
更新日期:2020-08-12 00:00:00