Abstract:
:Coarse-grained molecular dynamics simulations are applied to explore the experimentally observed ability of the liquid-ordered (lo)/liquid-disordered (ld) phase boundary to facilitate viral membrane fusion. Surprisingly, a formed fusion stalk can be both attracted (i.e., stalkophilic) and repelled (i.e., stalkophobic) by the lo/ld phase boundary. The phase boundary becomes stalkophilic if the lo phase constituents have the larger negative spontaneous curvature. In such a case, location of the highly curved stalk near the less-ordered and thus (relatively) softer boundary region becomes energetically favorable. These insights may explain why modeled viral fusion occurs preferentially near the lo/ld phase boundary.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Risselada HJdoi
10.1016/j.bpj.2017.04.031subject
Has Abstractpub_date
2017-06-20 00:00:00pages
2475-2478issue
12eissn
0006-3495issn
1542-0086pii
S0006-3495(17)30447-2journal_volume
112pub_type
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