Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report.

Abstract:

:Methadone use as a second-line agent for severe cancer-related pain is increasing in the field of hospice and palliative care. It has a number of qualities that make its use favorable, including lack of known active metabolites and presumed relative safety from adverse effects such as opioid-induced neurotoxicity (OIN). This article describes a case of a patient undergoing treatment of severe cancer-related pain who developed OIN in the setting of oral methadone use. As the use of methadone increases, more research into its pharmacologic and pharmacokinetic properties will be necessary.

journal_name

J Palliat Med

authors

Hoff AM,Hartwig KN,Rosielle DA

doi

10.1089/jpm.2016.0502

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1042-1044

issue

9

eissn

1096-6218

issn

1557-7740

journal_volume

20

pub_type

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