The Past, Present, and (Possible) Future of Serologic Testing for Lyme Disease.

Abstract:

:Lyme disease prevails as the most commonly transmitted tick-borne infection in the United States, and serologic evaluation for antibodies to Borrelia burgdorferi remains the recommended modality for diagnosis. This review presents a brief historical perspective on the evolution of serologic assays for Lyme disease and provides a summary of the performance characteristics for the currently recommended two-tiered testing algorithm (TTTA). Additionally, a recently proposed alternative to the traditional TTTA is discussed, and novel methodologies, including immuno-PCR and metabolic profiling for Lyme disease, are outlined.

journal_name

J Clin Microbiol

authors

Theel ES

doi

10.1128/JCM.03394-15

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

1191-6

issue

5

eissn

0095-1137

issn

1098-660X

pii

JCM.03394-15

journal_volume

54

pub_type

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